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Xuan Zhou Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Yanan Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Youwen Yuan Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Fei Teng Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Jiayang Lin Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Xueru Ye Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Yaojin Pan Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Huijie Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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cells were maintained in media containing 10% FBS, with 1 μg/mL insulin and 1 μM rosiglitazone to induce mature brown adipocytes. For inguinal white adipose tissue-stromal vascular fraction (iWAT-SVF) cells, differentiation was initiated with DMEM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0412
Volume/Issue:
Volume 262: Issue 2
Restricted access
Carsten T Herz Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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Florian W Kiefer Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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decision how beige cells are ultimately formed. Recently, a new hallmark of beige adipocytes has been identified using reporter mouse models that allow to tag white, beige and brown adipocytes. Warm temperatures confer a white fat program in both, beige

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0598
Volume/Issue:
Volume 241: Issue 3
Free access
Junlan Zhou
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Min Cheng Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Chan Boriboun
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Mariam M Ardehali
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Changfei Jiang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Qinghua Liu Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Shuling Han
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David A Goukassian Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Yao-Liang Tang Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ting C Zhao Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Ming Zhao
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Lu Cai Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Stéphane Richard Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Raj Kishore Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA

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Gangjian Qin
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(BAT), on the other hand, is a key site of energy expenditure via heat production (thermogenesis). The brown adipocytes display multilocular lipid droplet structures and express uncoupling protein 1 ( Ucp1 ), which, when activated, short circuits the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0727
Volume/Issue:
Volume 225: Issue 3
Free access
Gustavo W Fernandes
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Cintia B Ueta Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Tatiane L Fonseca Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Cecilia H A Gouveia Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Carmen L Lancellotti Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Patrícia C Brum Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Marcelo A Christoffolete Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Antonio C Bianco Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Miriam O Ribeiro Presbyterian University Mackenzie – Biological Science, Institute of Science Biomedical – Morpho-Functional Sciences, Department of Cell and Developmental Biology, Department of Anatomy, Santa Casa – AFIP and Pathology, School of Physical Education and Sport, Federal University of ABC – Human and Natural Sciences Center, Division of Endocrinology, Ciências Biológicas e da Saúde, CCBS, São Paulo, SP, Brazil

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Cardiovascular Pharmacology 27 33 – 36 . ( doi:10.1097/00005344-199601000-00006 ) Atgie C D'Allaire F Bukowiecki LJ 1997 Role of β 1 - and β 3 -adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes . American

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0526
Volume/Issue:
Volume 221: Issue 3
Free access
Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Ian Bloor Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Reham Alagal Department of Physical Sport Science, Princess Nourah Bint AbdulRahman University, Riyadh, Saudi Arabia

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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(UCP)1 located on the inner mitochondrial membrane, with beige fat possessing ~10-fold less UCP1 than classic brown adipocytes ( Cannon & Nedergaard 2011 ). When UCP1 is activated it enables the free flow of protons across the mitochondria without the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0075
Volume/Issue:
Volume 248: Issue 1
Free access
Silva Sütt Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Emmelie Cansby Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Alexandra Paul Department of Biology and Biological Engineering, Division of Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden

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Manoj Amrutkar Department of Hepato-Pancreato-Biliary Surgery, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

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Esther Nuñez-Durán Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Nagaraj M Kulkarni Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Marcus Ståhlman Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Jan Borén Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Jurga Laurencikiene Lipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

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Brian W Howell Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, USA

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Sven Enerbäck Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Margit Mahlapuu Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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milky appearance, compared with the BAT from WT controls ( Fig. 2A ). Consistently, histologic examination of H&E-stained BAT sections revealed the frequent presence of large, unilocular lipid droplets in the brown adipocytes of Stk25 transgenic mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0182
Volume/Issue:
Volume 238: Issue 3
Free access
Maria Namwanje Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Longhua Liu Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michelle Chan Department of Biological Sciences, Columbia University, New York, New York, USA

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Nikki Aaron Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA
Department of Pharmacology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michael J Kraakman Naomi Berrie Diabetes Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Li Qiang Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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) and lipogenic genes ( Srebf1 , Scd1 ) that were examined ( Fig. 8C ). Interestingly, this suppression seems to occur downstream of C/ebpβ in the adipogenic cascade. Due to the dedifferentiation of adipocytes, browning adipocyte markers were also

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0361
Volume/Issue:
Volume 240: Issue 2
Free access
Jinyu Ma Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yuejun Wang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Jie Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Shouping Zhang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yinuo Yang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Cheng Sun Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China

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). Genes involved in lipid catabolism such as Ucp1 , Ppara , Elovl3 , Cpt1b , Cidea , and Dio 2 were all stimulated by SAHA ( Fig. 1F ). Notably, all these stimulated genes are considered as brown adipocyte markers. Together, these findings imply

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0472
Volume/Issue:
Volume 249: Issue 3
Restricted access
Wang-Yang Xu State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, China

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Yan Shen State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Houbao Zhu State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Junhui Gao Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, China

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Chen Zhang Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, China

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Lingyun Tang State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Shun-Yuan Lu State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chun-Ling Shen State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hong-Xin Zhang State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Ziwei Li Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, China

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Peng Meng Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, China

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Ying-Han Wan Shanghai Research Center for Model Organisms, Shanghai, China

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Jian Fei Shanghai Research Center for Model Organisms, Shanghai, China

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Zhu-Gang Wang State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Research Center for Model Organisms, Shanghai, China
Model Organism Division, E-Institutes of Shanghai Universities, Shanghai, China

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-Shnaidman et al. 2010 ). In ‘browning’ adipocytes, the free fatty acids produced by β3AR-mediated lipolysis are used up for thermogenesis via UCP1 ( Ricquier et al. 1986 , Yehuda-Shnaidman et al. 2010 ). The activation of β3AR pathway in the white

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0157
Volume/Issue:
Volume 243: Issue 2
Restricted access
T’ng Choong Kwok University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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Roland H Stimson University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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. 2009 , Sharp et al. 2012 , Jespersen et al. 2013 , Porter et al. 2016 ). Human BAT biopsies and brown adipocyte cultures have been used to identify regulators of BAT function such as bile acids, glucocorticoids and the β2-adrenergic receptor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0017
Volume/Issue:
Volume 259: Issue 1
Open access