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Liqiong Song Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Wei Xia Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Zhao Zhou Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Yuanyuan Li Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Yi Lin Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Jie Wei Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Zhengzheng Wei Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Bing Xu Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Jie Shen Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Weiyong Li Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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Shunqing Xu Key Laboratory of Environment and Health, Tongji Medical College, Ministry of Education, School of Public Health, Tongji Medical College and

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, a variety of EDCs have been found to interfere with glucose metabolism ( Cranmer et al . 2000 , Alonso-Magdalena et al . 2010 , Hectors et al . 2011 , Lin et al . 2011 ). Physiological levels of estrogen are involved in maintaining normal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0219
Volume/Issue:
Volume 215: Issue 2
Free access
Marcello Maggiolini
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Didier Picard Department of Pharmaco-Biology, Département de Biologie Cellulaire, University of Calabria, 87030 Rende, Italy

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Discovery and history of GPR30 In contrast to what some text books might have advocated, for a lot of hormones and receptors, there is no one-to-one relationship. The steroid hormone estrogen, represented by the most potent physiological estrogen 17

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0242
Volume/Issue:
Volume 204: Issue 2
Free access
Kenichiro Watanabe Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Takahiro Nemoto Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Shigeo Akira Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Toshiyuki Takeshita Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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endometriosis ( Novembri et al . 2011 ). However, the regulatory mechanisms of Ucn2 expression in reproductive organs are not well understood. Estrogens regulate many physiological processes in both the reproductive system and the cardiovascular systems

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0228
Volume/Issue:
Volume 219: Issue 3
Free access
E E Connor Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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D L Wood Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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T S Sonstegard Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A F da Mota Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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G L Bennett Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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J L Williams Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A V Capuco Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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can be restored by estrogen administration ( Wallace 1953 ). Studies in rodents have confirmed these observations and demonstrated that estrogens are required for growth and morphogenesis of mammary ducts. Classical endocrine ablation and hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06139
Volume/Issue:
Volume 185: Issue 3
Free access
V L Clifton Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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R Crompton Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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M A Read Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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P G Gibson Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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R Smith Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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I M R Wright Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Introduction Females have a significantly greater life expectancy than males, which in part may be due to the cardio-protective effects of the female sex hormone, estrogen, on vascular function ( Sader & Celermajer 2002 ). However

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06030
Volume/Issue:
Volume 186: Issue 1
Free access
Lu Fu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China


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Hongyuan Zhang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China


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Jeremiah Ong’achwa Machuki Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Tingting Zhang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lin Han Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lili Sang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lijuan Wu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Zhiwei Zhao Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Matthew James Turley National Heart and Lung Institute, Imperial College London, UK

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Xide Hu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Hongjian Hou Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Dongye Li Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Sian E Harding National Heart and Lung Institute, Imperial College London, UK

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Hong Sun Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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happens in women and that the loss of estrogen contributes to the occurrence of SCM ( Brenner et al. 2012 , Porto et al. 2013 , Brenes-Salazar 2016 , Gori & Anadol 2018 ). In ovariectomized rats, Ueyama et al. reported that immobilization stress

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0451
Volume/Issue:
Volume 249: Issue 3
Restricted access
Terhi J Heino Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Andrei S Chagin Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Lars Sävendahl Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Introduction Estrogen (17β-estradiol) is an important regulator of bone metabolism, which is illustrated by the low bone mass phenotype in a man carrying a mutation in estrogen receptor-α (ERα; Smith et al . 1994 ) and in individuals with a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0629
Volume/Issue:
Volume 197: Issue 2
Free access
Lisa J Ma Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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Esther A Guzmán Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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Ariel DeGuzman Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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H Konrad Muller Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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Ameae M Walker Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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Laurie B Owen Division of Biomedical Sciences, The University of California, Riverside, California 92521, USA
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discipline of Pathology, University of Tasmania, Hobart, Tasmania 7000, Australia

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this study, we have examined DTH responses in females that were intact, ovariectomized (OVX), or were OVX with estrogen (E2) replacement, and males to ask which local cytokines are implicated as important players in the hormonal regulation of the DTH

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0024
Volume/Issue:
Volume 193: Issue 2
Free access
KC Westerlind
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KJ Gibson
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GL Evans
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RT Turner
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Recent data indicate that the catechol estrogen, 2-hydroxyestrone (2-OHE(1)), has no effect on any target tissue including bone, whereas 16 alpha-hydroxyestrone (16 alpha-OHE(1)) exerts tissue-selective estrogen agonist activity. The effect of the catechol estrogen, 4-hydroxyestrone (4-OHE(1)), putatively associated with tumorigenesis, has not been studied in the skeleton. The purpose of this study was to assess the effect of 4-OHE(1) on tibia, uterine and mammary gland histology and blood cholesterol in ovariectomized (OVX'd) growing rats. Ten-week-old female Sprague-Dawley rats were injected subcutaneously with 200 microg/kg BW per day with 4-OHE(1), 17 beta-estradiol (E(2)) or vehicle for three weeks. OVX resulted in uterine atrophy, increased body weight, radial bone growth and cancellous bone turnover, and hypercholesterolemia. E(2) prevented these changes with the expected exception that the subcutaneous infusion of this high dose of estrogen did not prevent the hypercholesterolemia. 4-OHE(1) prevented the increase in blood cholesterol and the increase in body weight. 4-OHE(1) appeared to have partial estrogen activity in the uterus; uterine weight and epithelial cell height were significantly greater than the OVX rats but significantly less (twofold) than the E(2) animals. Analysis of variance indicated that 4-OHE(1) slightly decreased the periosteal mineral apposition rate (P<0.05) compared with vehicle-treated rats but had no effect on double-labeled perimeter or bone formation rate. Similarly, 4-OHE(1) was a partial estrogen agonist on cancellous bone turnover. The data suggest that the catechol estrogen, 4-OHE(1), unlike 2-OHE(1), has estrogen activity. Furthermore, the profile of activity differs from that of 16 alpha-OHE(1). Our results suggest that estrogen metabolites may selectively influence estrogen-target tissues and, concomitantly, modulate estrogen-associated disease risk.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1670281
Volume/Issue:
Volume 167: Issue 2
Free access
J Varayoud Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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J G Ramos Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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L Monje Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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V Bosquiazzo Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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M Muñoz-de-Toro Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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E H Luque Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina

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Introduction Two different genes coding for the estrogen receptor (ER) have been identified: the classical ERα ( Koike et al. 1987 ) and the more recently characterized ERβ ( Kuiper et al. 1996 ). 17-β Estradiol (E 2 ) binds ERα

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06099
Volume/Issue:
Volume 186: Issue 1
Free access