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P Nguyen Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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S Khurana Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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H Peltsch Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Grandbois Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Eibl Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Crispo Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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D Ansell Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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T C Tai Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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.2006.125773 ) Tai TC Wong DL 2003 Protein kinase A and protein kinase C signaling pathway interaction in phenylethanolamine N -methyltransferase gene regulation . Journal of Neurochemistry 85 816 – 829 . ( doi:10.1046/j.1471

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0244
Volume/Issue:
Volume 227: Issue 2
Free access
Praveen Kumar Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Vishwa Mohan Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Rohit Anthony Sinha Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Megha Chagtoo Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Madan M Godbole Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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chromatin has been identified as a key epigenetic mechanism of gene regulation. VPA is in clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. However, VPA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0168
Volume/Issue:
Volume 227: Issue 2
Free access
Claire E Hills Department of Biological Sciences, Department of Infection, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK

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Paul E Squires
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Rosemary Bland
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stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells . American Journal of Physiology. Renal Physiology 294 F177 – F186 . Tsugawa T Shinohara R Nagasaka A Nakano I Takeda F Nagata M Oda N Sawai Y Hayakawa N Suzuki

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0295
Volume/Issue:
Volume 199: Issue 3
Free access
Menghong Yan CAS Key Laboratory of Nutrition and Metabolism, CAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Qiwei Zhai CAS Key Laboratory of Nutrition and Metabolism, CAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
School of Life Science and Technology, ShanghaiTech University, Shanghai, China

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fractions (<40nt) were purified from low-protein sperm and injected into control zygotes, it was found that RNAs from low-protein sperm could inhibit tRF–Gly–GCC targets in two-cell embryos, which indicates that paternal diet can affect preimplantation gene

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0185
Volume/Issue:
Volume 230: Issue 3
Free access
Charlotta Dabrosin Division of Gynaecologic Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden

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tissue in postmenopausal women. European Journal of Cancer and Clinical Oncology 22 515 –525. Zhou D , Zhou C & Chen S 1997 Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06163
Volume/Issue:
Volume 187: Issue 1
Free access
Stephen G Matthews Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Departments of Obstetrics & Gynaecology and Medicine, University of Toronto, Toronto, Ontario, Canada
Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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Patrick O McGowan Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Biological Sciences and Center for Environmental Epigenetics and Development, University of Toronto, Scarborough, Ontario, Canada
Department of Cell and Systems Biology, Department of Psychology, University of Toronto, Toronto, Ontario, Canada

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is considered a relatively stable epigenetic modification. However, it is important to note that transcription factors, not DNA methylation modifications themselves, are the drivers of gene regulation. This means that a true mechanistic understanding

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0057
Volume/Issue:
Volume 242: Issue 1
Free access
Nan Yang Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Giorgio Caratti Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Louise M Ince Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Toryn M Poolman Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Peter J Trebble Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Cathy M Holt Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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David W Ray Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Laura C Matthews Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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repeated three times. Graphs show mean± s.e.m . * P <0.05. NS, not significant. To define the role of JNK on endogenous gene regulation, again cells were transfected with activated JNK and then analysed by qRT-PCR. As expected both MT1X and FKBP5 were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0456
Volume/Issue:
Volume 223: Issue 2
Open access
Joyce Emons
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Bas E Dutilh Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Eva Decker Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Heide Pirzer Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Carsten Sticht Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Norbert Gretz Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Gudrun Rappold Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Ewan R Cameron Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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James C Neil Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Gary S Stein Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Andre J van Wijnen Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Jan Maarten Wit
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Janine N Post Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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Marcel Karperien Department of Paediatrics, Centre for Molecular and Biomolecular Informatics, Department of Human Molecular Genetics, Medical Research Center, Molecular Oncology Laboratory, Department of Cell Biology, Department of Tissue Regeneration, Leiden University Medical Center, 2300 ZA Leiden, The Netherlands

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promoter regions were scanned for six well-described transcription factor binding motifs selected from Jaspar 3.0 ( Sandelin et al . 2004 ) and Transfac 7.0 ( http://www.gene-regulation.com ). The motifs were ( Supplementary Table 1 , see section on

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0219
Volume/Issue:
Volume 209: Issue 2
Free access
Mitra Arianmanesh Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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Rebecca H McIntosh Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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Richard G Lea Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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Paul A Fowler Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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Kaïs H Al-Gubory Division of Applied Medicine, Department of Anatomical Sciences, School of Medical Sciences, School of Veterinary Medicine and Science, UMR 1198, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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1634 – 1650 doi:10.1016/j.biocel.2010.06.001 . Allen RG Tresini M 2000 Oxidative stress and gene regulation . Free Radical Biology and Medicine 28 463 – 499 doi:10.1016/S0891-5849(99)00242-7 . Arredondo F Noble LS 2006 Endocrinology

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0336
Volume/Issue:
Volume 210: Issue 1
Free access
Sean C Lema
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Jon T Dickey Physiology Program, School of Aquatic and Fishery Sciences, Pacific Northwest Division, Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA

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Irvin R Schultz Physiology Program, School of Aquatic and Fishery Sciences, Pacific Northwest Division, Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA

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Penny Swanson
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THs regulate a variety of cell functions by facilitating or inhibiting gene transcription, yet little is known about gene regulation by THs in adult teleosts. Here, we examined TH regulation of gene transcripts encoding thyrotropin subunits in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0472
Volume/Issue:
Volume 202: Issue 1
Free access