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Yoko Fujiwara, Masami Hiroyama, Atsushi Sanbe, Junji Yamauchi, Gozoh Tsujimoto, and Akito Tanoue

). Animals Male mice deficient in the V1b vasopressin receptor were generated by gene targeting as described previously ( Tanoue et al. 2004 ). Briefly, by homologous recombination, we disrupted exon 1, which contains the translation initiation

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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto

increase hybrid vigor as well as the increasing use of the Cre/LoxP system (which requires a tissue-specific Cre expressing and a LoxP-containing gene targeted mouse), the result0ant genetically modified mouse is frequently a conglomeration of two or more

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Mary C Gieske, Gi Youn Na, Yongbum Koo, Misung Jo, Thomas E Curry Jr, and Chemyong Ko

, Deng C, Sahu A, Lambris JD & Song WC 1999 Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. PNAS 96 628 –633. Ushigoe K , Irahara M

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K A Berghorn, P A Clark, B Encarnacion, C J DeRegis, J K Folger, M I Morasso, M J Soares, M W Wolfe, and M S Roberson

-gene cluster and the Dlx3 promoter by C/EBPβ in cells of trophoblast origin requires further study. An important gene target of Dlx3 is the human glycoprotein hormone α subunit gene promoter expressed in trophoblast cells ( Roberson et al. 2001 ). The α

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Qinglei Li, Fermin Jimenez-Krassel, Anilkumar Bettegowda, James J Ireland, and George W Smith

). Furthermore, a requirement of the progesterone receptor for ovulation in mice has been demonstrated using gene targeting technology ( Lydon et al. 1995 , 1996 ). Although data in the mouse support a potential role for progesterone-mediated regulation of a

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Shin Tsunekawa, Naoki Yamamoto, Katsura Tsukamoto, Yuji Itoh, Yukiko Kaneko, Toshihide Kimura, Yoh Ariyoshi, Yoshitaka Miura, Yutaka Oiso, and Ichiro Niki

; Yu et al. 2002 ). When we standardized these values by their pancreatic insulin content at this age ( Tsunekawa et al. 2005 ), ≈4.9 times overexpression of calmodulin was achieved by the gene targeting. The overexpression rate is relatively not

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Johan Svensson, Åsa Tivesten, Klara Sjögren, Olle Isaksson, Göran Bergström, Subburaman Mohan, Johan Mölne, Jörgen Isgaard, and Claes Ohlsson

, Schwenk F, Aguet M & Rajewsky K 1995 Inducible gene targeting in mice. Science 269 1427 –1429. Landin-Wilhelmsen K , Wilhelmsen L, Lappas G, Rosén T, Lindstedt G, Lundberg P-A & Bengtsson B-Å 1994 Serum insulin

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Diana Choi, Stephanie A Schroer, Shun Yan Lu, Erica P Cai, Zhenyue Hao, and Minna Woo

the course of diabetes development are therefore important for the prevention and treatment of diabetes. Gene targeting strategies can provide valuable tools to study the physiological function and pathophysiological role of individual apoptotic

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Da-Long Ren, Ai-Ai Sun, Ya-Juan Li, Min Chen, Shu-Chao Ge, and Bing Hu

Zebrafish arylalkylamine-N-acetyltransferase genes-targets for regulation of the circadian clock . Journal of Molecular Endocrinology 36 337 – 347 . ( doi:10.1677/jme.1.01893 ) Barrett P Bolborea M 2012 Molecular pathways involved in seasonal

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Véronique Serre-Beinier, Christian Toso, Philippe Morel, Carmen Gonelle-Gispert, Christelle Veyrat-Durebex, Françoise Rohner-Jeanrenaud, Thierry Calandra, Thierry Roger, Richard W James, Xavier Montet, Léo Bühler, Domenico Bosco, and Thierry Berney

Hospitalier Universitaire Vaudois, Lausanne, Switzerland). MIF−/− B6×129/Sv mice were generated by gene targeting as described previously ( Bozza et al . 1999 ). These mice were backcrossed for seven generations onto a B6 background. MIF−/− mice were