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Rosalba Senese
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Federica Cioffi Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Pieter de Lange
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Fernando Goglia Dipartimento di Scienze e Tecnologie Ambientali, Dipartimento di Scienze e Tecnologie, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

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Antonia Lanni
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Introduction General notions The thyroid gland produces two main iodothyronines: tetraiodo- l -thyronine (T 4 ) and triiodo- l -thyronine (T 3 ). In humans, T 4 is synthesized entirely within the thyroid and acts as a pro-hormone to generate T 3

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0573
Volume/Issue:
Volume 221: Issue 2
Free access
Juan Bernal Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid, Madrid, Spain

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Beatriz Morte Center for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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Diego Diez Immunology Frontier Research Center, Osaka University, Osaka, Japan

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Introduction Thyroid hormones are crucial for brain development, acting through nuclear receptors for T3 to control gene expression ( Brent 2012 , Mendoza & Hollenberg 2017 ). The amount of T3 reaching the nucleus of target cells depends

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0189
Volume/Issue:
Volume 255: Issue 3
Free access
Maria Alba Division of Endocrinology and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Roberto Salvatori Division of Endocrinology and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Introduction The production and secretion of growth hormone (GH) from the anterior pituitary is stimulated by the hypothalamic growth hormone releasing hormone (GHRH) and inhibited by somatostatin ( Muller et al. 1999 ). GHRH is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06213
Volume/Issue:
Volume 186: Issue 3
Free access
Arturo Hernandez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA
Graduate School for Biomedical Science and Engineering, University of Maine, Orono, Maine, USA
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA

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M Elena Martinez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA

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and cross-talk to ensure adequate cell function and hormone action in testicular tissue to support the maturation of germ cells into functional sperm ( Makela et al . 2019 ). The disruption of these processes may impair spermatogenesis and compromise

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0550
Volume/Issue:
Volume 244: Issue 3
Free access
Bernardo Nuche-Berenguer Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Daniel Lozano Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Irene Gutiérrez-Rojas Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Paola Moreno Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Mariñoso Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Pedro Esbrit Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Villanueva-Peñacarrillo Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Potvin Klein K 2001 Statins, hormones, and women: benefits and drawbacks for atherosclerosis and osteoporosis . Current Atherosclerosis Reports 3 35 – 42 doi:10.1007/s11883-001-0008-9 . Horton ES Silberman C Davis KL Berria R 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0015
Volume/Issue:
Volume 209: Issue 2
Free access
Ángela Sánchez Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Constanza Contreras-Jurado Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

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Diego Rodríguez Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Javier Regadera Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, Madrid, Spain

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Susana Alemany Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Ana Aranda Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

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animals ( Montecino-Rodriguez et al . 1997 , Foster et al . 1999 , Angelin-Duclos et al . 2005 , Zhang et al . 2017 ), demonstrating the important role of the thyroid hormones in hematopoiesis. Most actions of the active thyroid hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0339
Volume/Issue:
Volume 244: Issue 1
Restricted access
Ines Ross Department of Biological Sciences, San Jose State University, San Jose, California, USA

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Denzel B Omengan Department of Biological Sciences, San Jose State University, San Jose, California, USA
Cardiovascular Research Institute & Department of Physiology, University of California, San Francisco, San Francisco, California, USA
Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA

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Guo N Huang Cardiovascular Research Institute & Department of Physiology, University of California, San Francisco, San Francisco, California, USA
Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA

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Alexander Y Payumo Department of Biological Sciences, San Jose State University, San Jose, California, USA

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determine the physiological mechanisms driving the loss of mammalian heart regenerative potential after birth ( Porrello et al. 2011 , Wang et al. 2020 ). We have recently reported that increasing levels of thyroid hormones after birth are key drivers

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0335
Volume/Issue:
Volume 252: Issue 3
Free access
Maik Pietzner Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Tim Kacprowski Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan Technical University of Munich, Freising-Weihenstephan, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Introduction Thyroid hormone physiology and mode of action Thyroxine (T 4 ) and 3,3′,5-triiodo- l -thyronine (T 3 ), the main secretion products of the thyroid gland, are critical for proper development and function of almost all tissues

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0117
Volume/Issue:
Volume 238: Issue 1
Free access
Roger Guillemin Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA

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Factors ’ for the Journal’s celebration of the introduction of the word ‘hormone’ by Ernest H Starling in his 1905 Croonian Lectures ( Starling 1905 a ). Then came a no less gracious letter from Julian Davis with all sorts of practical editing

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.05883
Volume/Issue:
Volume 184: Issue 1
Free access
Bénédicte Rabier INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Allan J Williams INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Frederic Mallein-Gerin INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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Graham R Williams INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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O Chassande INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France

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plate remain unclear. In vivo , thyroid hormones regulate expression of parathyroid hormone related peptide (PTHrP) and PTHrP receptors, which control the pace of chondrocyte proliferation during endochondral ossification ( Stevens et al. 2000 ). In

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06838
Volume/Issue:
Volume 191: Issue 1
Free access