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Taira Wada Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Yamamoto Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Takasugi Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Hirotake Ishii Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Taketo Uchiyama Laboratory of Organic Chemistry, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Kaori Saitoh Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Masahiro Suzuki Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Makoto Uchiyama Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
Tokyo Adachi Hospital, Adachi, Tokyo, Japan

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Hikari Yoshitane Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Yoshitaka Fukada Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Shigeki Shimba Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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, Shimba et al. 2011 ). Conversely, obesity simultaneously decreases the expression of clock genes in each tissue; for example, a high-fat diet can alter the rhythmic expression of clock genes in the liver and the adipose tissue and affect behavioral

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Rodrigo Martins Pereira Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Kellen Cristina da Cruz Rodrigues Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Chadi Pellegrini Anaruma Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Marcella Ramos Sant’Ana Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Thaís Dantis Pereira de Campos Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rodrigo Stellzer Gaspar Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Raphael dos Santos Canciglieri Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Diego Gomes de Melo Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rania A Mekary Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA

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Adelino Sanchez Ramos da Silva School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Dennys Esper Cintra Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Eduardo Rochete Ropelle Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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José Rodrigo Pauli Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Leandro Pereira de Moura Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Introduction Nonalcoholic fatty liver disease (NAFLD) is a pre-condition for most common liver diseases, and it can be developed from hepatic steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, to hepatocellular carcinoma (HCC) ( Tilg

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Jennifer A Crookshank Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Daniel Serrano Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Gen-Sheng Wang Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Christopher Patrick Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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Baylie S Morgan Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada

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Marie-France Paré Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Fraser W Scott Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

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identified differences in genes involved in the endoplasmic reticulum (ER) stress response, metabolism and apoptosis in prediabetic pancreas of BBdp rats. Candidate genes and associated pathways were further investigated in pancreas and liver from non

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Sebastian R Vanin Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Kendrick Lee Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Mina Nashed Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Brennan Tse Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Mohammed Sarikahya Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Sukham Brar Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Gregg Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Amica-Mariae Lucas Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Thane Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Steven R Laviolette Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Edith J Arany Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Daniel B Hardy Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
The Lawson Health Research Institute and the Children's Health Research Institute, London, Ontario, Canada

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effects on glucose regulation ( Matias & Di Marzo 2007 ). Indeed, the ECS in the pancreas is involved in the development of the endocrine islets, as well as glucose-stimulated insulin secretion ( Malenczyk et al. 2013 , 2015 ). Moreover, in the liver

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Norio Masumoto Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Chise Tateno Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Asato Tachibana Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Rie Utoh Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Yoshio Morikawa Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Takashi Shimada Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Hiroyuki Momisako Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Toshiyuki Itamoto Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Toshimasa Asahara Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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Katsutoshi Yoshizato Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan

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)-hepatocytes in vivo have not been studied due to the lack of a suitable animal model. Previously, we developed a method to yield humanized mice (chimeric mice) whose liver is mostly replaced with h -hepatocytes ( Tateno et al. 2004 ). The h -hepatocytes

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Adrián Báez-Ruiz Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Natalí N Guerrero-Vargas Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Fernando Cázarez-Márquez Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Elizabeth Sabath Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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María del Carmen Basualdo Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Roberto Salgado-Delgado Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Carolina Escobar Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Ruud M Buijs Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Martelot et al. 2009 , Polidarová et al. 2016 ). Also, the fed-fasting cycle driven by the SCN acts as entraining signals for cellular processes in the liver, adipose tissue and muscle ( Dibner et al. 2010 , Buijs et al. 2013 ). In agreement

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Lorena González Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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Johanna G Miquet Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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Pablo E Irene Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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M Eugenia Díaz Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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Soledad P Rossi Instituto de Biología y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina

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Ana I Sotelo Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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Mónica B Frungieri Instituto de Biología y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina

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Cristal M Hill Departments of Internal Medicine and Physiology, Geriatrics Research, School of Medicine, Southern Illinois University, Springfield, Illinois, USA

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Andrzej Bartke Departments of Internal Medicine and Physiology, Geriatrics Research, School of Medicine, Southern Illinois University, Springfield, Illinois, USA

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Daniel Turyn Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

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. 2011 ). Hepatic EGF binding is diminished in hypophysectomized and in partially GH-deficient mutant ‘little’ (lit/lit) mice due to reduced EGFR levels; GH replacement therapy restores EGF binding to liver cells in these animals ( Jansson et al . 1988

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Bel M Galmés-Pascual Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Antonia Nadal-Casellas Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain

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Marco Bauza-Thorbrügge Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Miquel Sbert-Roig Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Francisco J García-Palmer Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Ana M Proenza Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Magdalena Gianotti Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Isabel Lladó Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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-inducible coactivator of adaptive thermogenesis and mitochondrial biogenesis, in both brown adipose tissue and skeletal muscle, where it is abundantly expressed ( Puigserver et al. 1998 , Liu & Lin 2011 ). PGC1A levels in liver are minimal under fed condition but a

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L Francisco Lorenzo-Martín Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Mauricio Menacho-Márquez Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Salvatore Fabbiano Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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Omar Al-Massadi Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Antonio Abad Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Sonia Rodríguez-Fdez Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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María A Sevilla Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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María J Montero Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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Carlos Diéguez Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Rubén Nogueiras Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Xosé R Bustelo Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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mice and the progressive development of SNS-associated dysfunctions such as hypertension, hypertension-associated morbidities (e.g., cardiovascular remodeling, kidney fibrosis), tachycardia, tachypnea, liver steatosis, insulin resistance, hyperlipidemia

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Yujiao Dai School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Peng Hao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhimei Sun School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhiyi Guo School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Hong Xu School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Lihui Xue Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Hongyu Song Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Yida Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Shuang Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Mingming Gao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Teng Si School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Yuxin Zhang School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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Yajuan Qi School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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Introduction Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM), which is caused by chronic liver injury ( Hui & Friedman 2004 ) due to schistosomiasis and chronic viral hepatitis infection, non

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