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Tokyo Adachi Hospital, Adachi, Tokyo, Japan
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, Shimba et al. 2011 ). Conversely, obesity simultaneously decreases the expression of clock genes in each tissue; for example, a high-fat diet can alter the rhythmic expression of clock genes in the liver and the adipose tissue and affect behavioral
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Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA
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Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil
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Introduction Nonalcoholic fatty liver disease (NAFLD) is a pre-condition for most common liver diseases, and it can be developed from hepatic steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, to hepatocellular carcinoma (HCC) ( Tilg
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada
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identified differences in genes involved in the endoplasmic reticulum (ER) stress response, metabolism and apoptosis in prediabetic pancreas of BBdp rats. Candidate genes and associated pathways were further investigated in pancreas and liver from non
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The Lawson Health Research Institute and the Children's Health Research Institute, London, Ontario, Canada
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effects on glucose regulation ( Matias & Di Marzo 2007 ). Indeed, the ECS in the pancreas is involved in the development of the endocrine islets, as well as glucose-stimulated insulin secretion ( Malenczyk et al. 2013 , 2015 ). Moreover, in the liver
Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
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Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
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Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
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Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
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)-hepatocytes in vivo have not been studied due to the lack of a suitable animal model. Previously, we developed a method to yield humanized mice (chimeric mice) whose liver is mostly replaced with h -hepatocytes ( Tateno et al. 2004 ). The h -hepatocytes
Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México
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Department of Anatomy, Faculty of Medicine, UNAM, DF, México
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Martelot et al. 2009 , Polidarová et al. 2016 ). Also, the fed-fasting cycle driven by the SCN acts as entraining signals for cellular processes in the liver, adipose tissue and muscle ( Dibner et al. 2010 , Buijs et al. 2013 ). In agreement
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. 2011 ). Hepatic EGF binding is diminished in hypophysectomized and in partially GH-deficient mutant ‘little’ (lit/lit) mice due to reduced EGFR levels; GH replacement therapy restores EGF binding to liver cells in these animals ( Jansson et al . 1988
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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-inducible coactivator of adaptive thermogenesis and mitochondrial biogenesis, in both brown adipose tissue and skeletal muscle, where it is abundantly expressed ( Puigserver et al. 1998 , Liu & Lin 2011 ). PGC1A levels in liver are minimal under fed condition but a
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
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Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
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Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain
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Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain
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Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
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mice and the progressive development of SNS-associated dysfunctions such as hypertension, hypertension-associated morbidities (e.g., cardiovascular remodeling, kidney fibrosis), tachycardia, tachypnea, liver steatosis, insulin resistance, hyperlipidemia
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Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
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Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
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Introduction Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM), which is caused by chronic liver injury ( Hui & Friedman 2004 ) due to schistosomiasis and chronic viral hepatitis infection, non