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Neerav Mullur
Neerav Mullur
The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada
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Arianne Morissette
Arianne Morissette
The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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Nadya M Morrow
Nadya M Morrow
The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada
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Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada
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Erin E Mulvihill
Erin E Mulvihill
The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada
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Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada
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by leading to more significant weight loss, a greater percentage of individuals attaining weight loss, further lowering lipid levels, improving T2DM management, and enhancing overall substrate metabolism compared to the use of GLP-1R agonists alone
Rachel Botchlett
Rachel Botchlett
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Pinnacle Clinical Research, Live Oak, USA
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Pinnacle Clinical Research, Live Oak, USA
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Shih-Lung Woo
Shih-Lung Woo
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
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Mengyang Liu
Mengyang Liu
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
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Ya Pei
Ya Pei
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
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Xin Guo
Xin Guo
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Baylor College of Medicine, Houston, USA
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Baylor College of Medicine, Houston, USA
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Honggui Li
Honggui Li
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
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Chaodong Wu
Chaodong Wu
Department of Nutrition and Food Science, Texas A&M University, College Station, USA
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of the obesity-associated diseases that can cause serious health problems ( Wilson et al. 2002 , Bhaskaran et al. 2014 ). Although disturbing physiological metabolism and exacerbating other metabolic problems, these obesity-associated diseases
Michael E Symonds
Michael E Symonds
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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Peter Aldiss
Peter Aldiss
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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Neele Dellschaft
Neele Dellschaft
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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James Law
James Law
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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Hernan P Fainberg
Hernan P Fainberg
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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Mark Pope
Mark Pope
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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Harold Sacks
Harold Sacks
VA Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
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Helen Budge
Helen Budge
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
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Introduction Although brown adipose tissue (BAT) may be one of the smallest fat depots in the adult, it has the potential to have a substantial influence on energy balance, as well as glucose and lipid metabolism ( Cannon & Nedergaard 2012 b
Gabriel O de Souza
Gabriel O de Souza
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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Fernanda M Chaves
Fernanda M Chaves
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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Josiane N Silva
Josiane N Silva
Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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João A B Pedroso
João A B Pedroso
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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Martin Metzger
Martin Metzger
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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Renata Frazão
Renata Frazão
Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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Jose Donato
Jose Donato
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
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wall of the third ventricle ( Szilvasy-Szabo et al. 2017 ). Tanycytes, via a CX43-dependent mechanism, supply lactate to ARH POMC neurons, regulating feeding behavior and energy metabolism ( Lhomme et al. 2021 ). A recent study revealed that
Isis Gabrielli Barbieri de Oliveira
Isis Gabrielli Barbieri de Oliveira
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Marcos Divino Ferreira Junior
Marcos Divino Ferreira Junior
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Paulo Ricardo Lopes
Paulo Ricardo Lopes
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Dhiogenes Balsanufo Taveira Campos
Dhiogenes Balsanufo Taveira Campos
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Marcos Luiz Ferreira-Neto
Marcos Luiz Ferreira-Neto
Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil
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Eduardo Henrique Rosa Santos
Eduardo Henrique Rosa Santos
Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil
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Paulo Cezar de Freitas Mathias
Paulo Cezar de Freitas Mathias
Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil
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Flávio Andrade Francisco
Flávio Andrade Francisco
Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil
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Bruna Del Vechio Koike
Bruna Del Vechio Koike
Medical Department, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
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Carlos Henrique de Castro
Carlos Henrique de Castro
Department of Physiological Science, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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André Henrique Freiria-Oliveira
André Henrique Freiria-Oliveira
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Gustavo Rodrigues Pedrino
Gustavo Rodrigues Pedrino
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Rodrigo Mello Gomes
Rodrigo Mello Gomes
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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Daniel Alves Rosa
Daniel Alves Rosa
Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil
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metabolic outcomes. Here, we hypothesized that the desynchronization of circadian rhythm could be a risk factor of the onset of cardiometabolic disorders associated with disruptions of the hypothalamic–pituitary–adrenal axis and liver metabolism. In this way
Iris Boraschi-Diaz
Iris Boraschi-Diaz
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Josephine T Tauer
Josephine T Tauer
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
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Omar El-Rifai
Omar El-Rifai
Unité de Recherche en Physiologie Intégrative et Moléculaire, Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada
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Delphine Guillemette
Delphine Guillemette
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Geneviève Lefebvre
Geneviève Lefebvre
Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Frank Rauch
Frank Rauch
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
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Mathieu Ferron
Mathieu Ferron
Unité de Recherche en Physiologie Intégrative et Moléculaire, Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada
Départements de Médecine et de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada
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Départements de Médecine et de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada
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Svetlana V Komarova
Svetlana V Komarova
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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undercarboxylated form ( Ferron et al . 2010 a , 2015 , Lacombe et al . 2013 ). OCN influences glucose metabolism through regulation of both insulin secretion and sensitivity ( Lee et al . 2007 , Ferron et al . 2008 ). OCN leads to decrease in adiposity and
Christopher M Mulligan
Christopher M Mulligan
Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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Jacob E Friedman
Jacob E Friedman
Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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factors on the maternal and infant microbiota. Maternal factors significantly contribute to the initial colonization and succession of the infant gut microbiota. Alterations in this process may have long-term health consequences related to host metabolism
Peixin Li
Peixin Li
Department of Comprehensive Surgery, Medical and Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
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East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
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Zhijian Rao
Zhijian Rao
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Brenton Thomas Laing
Brenton Thomas Laing
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Wyatt Bunner
Wyatt Bunner
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Taylor Landry
Taylor Landry
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
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Amber Prete
Amber Prete
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
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Yuan Yuan
Yuan Yuan
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
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Zhong-Tao Zhang
Zhong-Tao Zhang
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, People’s Republic of China
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Hu Huang
Hu Huang
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Department of Physiology, East Carolina University, Greenville, North Carolina, USA
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Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Department of Physiology, East Carolina University, Greenville, North Carolina, USA
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Metabolic Hormone Magnetic Bead Panel – Metabolism Multiplex Assay (MMHMAG-44K, Millipore). Serum triglycerides level was measured with Triglyceride Assay Kit (ab65336, Abcam). Determination of insulin resistance by homeostasis model assessment of
Tanja Jene
Tanja Jene
Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Inigo Ruiz de Azua
Inigo Ruiz de Azua
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Annika Hasch
Annika Hasch
Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Jennifer Klüpfel
Jennifer Klüpfel
Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Julia Deuster
Julia Deuster
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Mirjam Maas
Mirjam Maas
Department for Developmental Origins of Disease, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Cora H Nijboer
Cora H Nijboer
Department for Developmental Origins of Disease, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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Beat Lutz
Beat Lutz
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Marianne B Müller
Marianne B Müller
Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Michael A van der Kooij
Michael A van der Kooij
Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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Leibniz Institute for Resilience Research (LIR), Mainz, Germany
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metabolic disorders ( Scott et al. 2012 ). Thus, understanding how chronic stress affects metabolism represents an important research question in biomedical sciences that remains to be fully addressed. Chronic stress challenges homeostatic processes with
Philip Newsholme
Philip Newsholme
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia
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Vinicius Cruzat
Vinicius Cruzat
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia
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Frank Arfuso
Frank Arfuso
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia
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Kevin Keane
Kevin Keane
School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia
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Introduction Homoeostatic regulation of fuel metabolism in the body is a tightly controlled process and dysregulation can lead to pathological conditions such as diabetes mellitus (DM), cardiovascular disease, stroke, renal disease and other
