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C J Corbin Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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E L Legacki Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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B A Ball Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA

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K E Scoggin Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA

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S D Stanley Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA

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A J Conley Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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play a role in pregnancy and parturition in some species ( Mahendroo & Russell 1999 , Scholtz et al . 2014 ). These isozymes are expressed in various male reproductive tissues including the epididymis ( Robaire et al . 1977 ), where they reduce

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0175
Volume/Issue:
Volume 231: Issue 1
Free access
Erin L Fee Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia

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Sarah J Stock University of Edinburgh Usher Institute, Edinburgh, Scotland, UK

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Matthew W Kemp Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia
School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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& Dalziel 2006 , McGoldrick et al. 2020 ). Endogenous glucocorticoids are essential for normal fetal development, and a surge of circulating glucocorticoids in late pregnancy facilitates normal maturation of the fetal lungs, heart, brain, and kidneys

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0306
Volume/Issue:
Volume 258: Issue 2
Free access
David R Grattan Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand

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hyperprolactinemia during lactation, and thereby promote the milk production that is essential to this state, there is an apparent loss of sensitivity of the short-loop feedback system during late pregnancy and lactation ( Grattan et al . 2008 ). This is a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0213
Volume/Issue:
Volume 226: Issue 2
Open access
Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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discuss the plethora of evidence demonstrating that ACE2 drives COVID-19 age, sex, and pregnancy-associated vulnerabilities and the culminating need for greater understanding of ACE2 and its pathophysiological role. The objective of this narrative review

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0262
Volume/Issue:
Volume 258: Issue 3
Free access
Antonio Gázquez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Francisca Rodríguez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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María Sánchez-Campillo Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Lidia E Martínez-Gascón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Marino B Arnao Department of Plant Biology (Plant Physiology), University of Murcia, Murcia, Spain

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Pedro Saura-Garre Department of Clinical Psychology, University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain

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María D Albaladejo-Otón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Elvira Larqué Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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is affected by hyperglycaemia in pregnancy, most of those due to GDM ( International Diabetes Federation 2017 ). GDM is associated with neonatal adverse outcomes such as large for gestational age infants and increased risk of obesity and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0617
Volume/Issue:
Volume 251: Issue 1
Open access
Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Peter Aldiss Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Neele Dellschaft Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Hernan P Fainberg Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Harold Sacks VA Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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purchase of processed foods compared with the rest of Europe ( Monteiro et al . 2018 ). Maternal obesity during pregnancy can directly influence infant size and metabolic characteristics from conception onward, is one of the main predicting factors of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0084
Volume/Issue:
Volume 238: Issue 1
Free access
D S Boeldt Department of Ob/Gyn, Perinatal Research Laboratories, University Wisconsin – Madison, Madison, Wisconsin, USA

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I M Bird Department of Ob/Gyn, Perinatal Research Laboratories, University Wisconsin – Madison, Madison, Wisconsin, USA

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Introduction Preeclampsia (PE), a hypertensive disorder of pregnancy, has been described for centuries, and the physiology has been studied intensively for decades. Still, effective therapies have proven elusive. One barrier to our

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0340
Volume/Issue:
Volume 232: Issue 1
Free access
Kok Lim Kua Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Shanming Hu Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Chunlin Wang Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Jianrong Yao Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Diana Dang Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Alexander B Sawatzke Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Jeffrey L Segar Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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Kai Wang Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA

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Andrew W Norris Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA

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Introduction Offspring born from pregnancy complicated by diabetes have a lifelong increased risk of insulin resistance. In humans, such offspring have a 4- to 8-fold higher risk, beyond genetic risk, to develop type 2 diabetes, metabolic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0455
Volume/Issue:
Volume 242: Issue 1
Free access
Joyce Wang
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Qing Qiu Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Maliha Haider Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Michael Bell Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Andrée Gruslin Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6
Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6

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Julian K Christians
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bioavailability of which is aided by proteases ( Lala & Hamilton 1996 , Salamonsen 1999 ). One of the critical proteases involved in normal placental development is pregnancy-associated plasma protein-A (PAPPA; Sun et al . 2002 ), which is produced by human

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0136
Volume/Issue:
Volume 202: Issue 3
Free access
Sandra K Szlapinski Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Anthony A Botros Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Sarah Donegan Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Renee T King Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Gabrielle Retta Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Brenda J Strutt Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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David J Hill Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
Lawson Health Research Institute, St Joseph’s Health Care, London, Ontario, Canada

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Introduction Pregnancy presents as a unique situation of endocrine pancreas β-cell adaptation that reverses after parturition. Late pregnancy is characterized by a state of peripheral maternal insulin resistance mediated by placental hormones

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0012
Volume/Issue:
Volume 245: Issue 2
Restricted access