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this disease every year ( Ferlay et al. 2015 ). Approximately 70% of breast tumors are estrogen receptor α (ERα) positive, and tumor cell proliferation is thought to be dependent on the activity of this hormone-mediated transcription factor ( Hayashi
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factor NeuroD1 avoided exocrine transdifferentiation ( Kojima et al . 2003 ). More recently, transdifferentiation to insulin-producing cells, without exocrine differentiation, has been achieved in mice with adenovirus delivery of multiple transcription
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Introduction The transcriptional networks driving mammalian cell development and function are only beginning to be elucidated. In many tissues transcription factors critical to normal development and function have been identified but, in general
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Cell and Developmental Biology, Departments of
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target genes required for proper islet cell function. MafA and MafB were only recently linked to Insulin and Glucagon expression and represent the principal members of the large Maf transcription factor family expressed in the pancreas ( Olbrot et al
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
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Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
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Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
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in the pathobiology of uterine endometrial and breast cancers. Figure 1 Cladogram of the human Sp and KLF transcription factors. The 110-aa domain containing the buttonhead box (BTD)/zinc finger motifs was used for the multiple alignment with ClustalW
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primordium and the correct morphogenesis of the gland require the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors that will eventually dictate organ commitment, cell proliferation, patterning and
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Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Journal of Biological Chemistry 278 751 –756. Clark AR , Wilson ME, Leibiger I, Scott V & Docherty K 1995 A silencer and an
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Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA
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absent steroid hormone production and enlarged adrenal glands. Transcription factors, such as cAMP response element-binding protein (CREB), steroidogenic factor 1 (SF-1) and adrenal hypoplasia critical region on chromosome X gene 1 (DAX-1 or NR0B1), may
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immunofluorescent staining was performed. There were two sets of co-expression pattern studies. First co-expression of nestin with transcription factors was examined. Co-staining of nestin with PDX-1 was observed at 15±4% in the monolayers after 2 months of culture
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signalling pathways leading to the activation of transcription factors, with the NFκB pathway being of particular importance. The control of osteoclast differentiation and function by signalling pathways is highlighted by conditions in which key components of
