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Abdullah Cim, Greta J Sawyer, Xiaohong Zhang, Haibin Su, Louise Collins, Peter Jones, Michael Antoniou, Jean-Paul Reynes, Hans-Joachim Lipps, and John W Fabre

factor NeuroD1 avoided exocrine transdifferentiation ( Kojima et al . 2003 ). More recently, transdifferentiation to insulin-producing cells, without exocrine differentiation, has been achieved in mice with adenovirus delivery of multiple transcription

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Brad G Hoffman and Steven J M Jones

Introduction The transcriptional networks driving mammalian cell development and function are only beginning to be elucidated. In many tissues transcription factors critical to normal development and function have been identified but, in general

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Isabella Artner, Yan Hang, Min Guo, Guoqiang Gu, and Roland Stein

target genes required for proper islet cell function. MafA and MafB were only recently linked to Insulin and Glucagon expression and represent the principal members of the large Maf transcription factor family expressed in the pancreas ( Olbrot et al

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R C M Simmen, J M P Pabona, M C Velarde, C Simmons, O Rahal, and F A Simmen

in the pathobiology of uterine endometrial and breast cancers. Figure 1 Cladogram of the human Sp and KLF transcription factors. The 110-aa domain containing the buttonhead box (BTD)/zinc finger motifs was used for the multiple alignment with ClustalW

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Kyriaki S Alatzoglou, Daniel Kelberman, and Mehul T Dattani

primordium and the correct morphogenesis of the gland require the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors that will eventually dictate organ commitment, cell proliferation, patterning and

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John Le Lay and Roland Stein

Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Journal of Biological Chemistry 278 751 –756. Clark AR , Wilson ME, Leibiger I, Scott V & Docherty K 1995 A silencer and an

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Ying-Ying Tsai, William E Rainey, and Wendy B Bollag

absent steroid hormone production and enlarged adrenal glands. Transcription factors, such as cAMP response element-binding protein (CREB), steroidogenic factor 1 (SF-1) and adrenal hypoplasia critical region on chromosome X gene 1 (DAX-1 or NR0B1), may

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R Wang, J Li, N Yashpal, and N Gao

immunofluorescent staining was performed. There were two sets of co-expression pattern studies. First co-expression of nestin with transcription factors was examined. Co-staining of nestin with PDX-1 was observed at 15±4% in the monolayers after 2 months of culture

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David J Mellis, Cecile Itzstein, Miep H Helfrich, and Julie C Crockett

signalling pathways leading to the activation of transcription factors, with the NFκB pathway being of particular importance. The control of osteoclast differentiation and function by signalling pathways is highlighted by conditions in which key components of

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Ralf Baumeister, Elke Schaffitzel, and Maren Hertweck

negatively regulate the FOXO transcription factor DAF-16. Inhibition of the daf-2 receptor gene expression/activity or other genes in the insulin/IGF pathway can have three effects. (A) Early developmental downregulation, which affects many biological