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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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this disease every year ( Ferlay et al. 2015 ). Approximately 70% of breast tumors are estrogen receptor α (ERα) positive, and tumor cell proliferation is thought to be dependent on the activity of this hormone-mediated transcription factor ( Hayashi

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Abdullah Cim
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Greta J Sawyer
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Xiaohong Zhang
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Haibin Su
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Louise Collins
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Peter Jones Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Michael Antoniou Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Jean-Paul Reynes Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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Hans-Joachim Lipps Department of Hepatology and Transplantation, Diabetes Research Group, Department of Medical and Molecular Genetics, InvivoGen, Institut für Zellbiologie, King's College London School of Medicine, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK

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John W Fabre
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factor NeuroD1 avoided exocrine transdifferentiation ( Kojima et al . 2003 ). More recently, transdifferentiation to insulin-producing cells, without exocrine differentiation, has been achieved in mice with adenovirus delivery of multiple transcription

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Brad G Hoffman
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Steven J M Jones Department of Cancer Endocrinology, Micheal Smith Genome Sciences Centre, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3

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Introduction The transcriptional networks driving mammalian cell development and function are only beginning to be elucidated. In many tissues transcription factors critical to normal development and function have been identified but, in general

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Isabella Artner Cell and Developmental Biology, Departments of

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Yan Hang Cell and Developmental Biology, Departments of

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Min Guo Cell and Developmental Biology, Departments of

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Guoqiang Gu Cell and Developmental Biology, Departments of

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Roland Stein Cell and Developmental Biology, Departments of
Cell and Developmental Biology, Departments of

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target genes required for proper islet cell function. MafA and MafB were only recently linked to Insulin and Glucagon expression and represent the principal members of the large Maf transcription factor family expressed in the pancreas ( Olbrot et al

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R C M Simmen Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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J M P Pabona Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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M C Velarde Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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C Simmons Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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O Rahal Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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F A Simmen Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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in the pathobiology of uterine endometrial and breast cancers. Figure 1 Cladogram of the human Sp and KLF transcription factors. The 110-aa domain containing the buttonhead box (BTD)/zinc finger motifs was used for the multiple alignment with ClustalW

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Kyriaki S Alatzoglou Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Daniel Kelberman Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Mehul T Dattani Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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primordium and the correct morphogenesis of the gland require the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors that will eventually dictate organ commitment, cell proliferation, patterning and

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John Le Lay Department of Molecular Physiology and Biophysics, Vanderbilt University, 2001 West End Ave Nashville, Tennessee 37235, USA

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Roland Stein Department of Molecular Physiology and Biophysics, Vanderbilt University, 2001 West End Ave Nashville, Tennessee 37235, USA

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Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Journal of Biological Chemistry 278 751 –756. Clark AR , Wilson ME, Leibiger I, Scott V & Docherty K 1995 A silencer and an

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Ying-Ying Tsai Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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William E Rainey Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Wendy B Bollag Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA

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absent steroid hormone production and enlarged adrenal glands. Transcription factors, such as cAMP response element-binding protein (CREB), steroidogenic factor 1 (SF-1) and adrenal hypoplasia critical region on chromosome X gene 1 (DAX-1 or NR0B1), may

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R Wang
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J Li
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N Yashpal
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N Gao
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immunofluorescent staining was performed. There were two sets of co-expression pattern studies. First co-expression of nestin with transcription factors was examined. Co-staining of nestin with PDX-1 was observed at 15±4% in the monolayers after 2 months of culture

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David J Mellis Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Cecile Itzstein Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Miep H Helfrich Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Julie C Crockett Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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signalling pathways leading to the activation of transcription factors, with the NFκB pathway being of particular importance. The control of osteoclast differentiation and function by signalling pathways is highlighted by conditions in which key components of

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