Foxo knockout mice using the Cre-LoxP genetic approaches Tissue-specific Irs or Foxo null mouse genotype Phenotype Cre-mice References Hypothalamic and β-cell Irs2 −/− Obesity; hyperglycemia; insulin resistance RIP-cre Lin et al . (2004
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Marco Hatem-Vaquero, Mercedes Griera, Andrea García-Jerez, Alicia Luengo, Julia Álvarez, José A Rubio, Laura Calleros, Diego Rodríguez-Puyol, Manuel Rodríguez-Puyol, and Sergio De Frutos
homozygous for the floxed Ilk allele, flanked by loxP sites (LOX) with homozygous BALB/cJ strain mice carrying a CMV-driven tamoxifen-inducible CreER (T) recombinase gene (CRE); three-month-old male CRE-LOX mice weighing 20–28 g were injected
Rachel V Richardson, Emma J Batchen, Adrian J W Thomson, Rowan Darroch, Xinlu Pan, Eva A Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A S Al-Dujaili, Mary E Diaz, Carmel M Moran, Christopher J Kenyon, Gillian A Gray, and Karen E Chapman
reduced (rather than increased) in another GR-knockout model (Meijer et al . 1997). Elevated MR expression has been suggested to drive cardiac fibrosis ( Lother et al . 2011 ), and MR antagonism is protective in murine models of pressure
Edouard G A Mills, Waljit S Dhillo, and Alexander N Comninos
kisspeptin signalling in female rodent partner preference. To determine if the role of kisspeptin in partner preference is dependent on downstream GnRH, a mouse line, GnRH:: Cre; Dicer loxP/loxP , in which mice display a phenotype characterised by
Sébastien Desarzens and Nourdine Faresse
disrupted GR expression in mouse adipose tissues using Cre-loxP-mediated recombination. We found that reduction of GR expression in adipose tissue was not essential for adipose tissue growth and did not lead to major metabolic disturbances on a standard or a
Chunchun Wei, Xianhua Ma, Kai Su, Shasha Qi, Yuangang Zhu, Junjian Lin, Chenxin Wang, Rui Yang, Xiaowei Chen, Weizhong Wang, and Weiping J Zhang
delineating the function of these two isoforms. In this study, we took advantage of the Cre/LoxP approach to generate a mouse model with BAT-specific over e xpression of the t ransgene ChREBP-β, hereafter designated BET-β. Unexpectedly, ChREBP
Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl, and Karen E Chapman
flanked by LoxP sites ( Hsd11b1 f/f mice) (recombination strategy shown in Supplementary Fig. 1). LysM-Cre transgenic mice are reported to efficiently delete LoxP -flanked target genes in granulocytes and mature macrophages, with lower efficiencies
Mariana Rosolen Tavares, Simone Ferreira Lemes, Thais de Fante, Cristina Saenz de Miera, Isadora Carolina Betim Pavan, Rosangela Maria Neves Bezerra, Patricia Oliveira Prada, Marcio Alberto Torsoni, Carol Fuzeti Elias, and Fernando Moreira Simabuco
activation is neuron type and context dependent ( Hu et al. 2016 ). In order to surpass these limitations, we used a Cre-loxP system in a conditional approach to investigate a possible role of S6K2 isoform selectively in AgRP neurons, due to the lack of
Johan Svensson, Åsa Tivesten, Klara Sjögren, Olle Isaksson, Göran Bergström, Subburaman Mohan, Johan Mölne, Jörgen Isgaard, and Claes Ohlsson
, exercise, and age ( Landin-Wilhelmsen et al. 1994 , Kaklamani et al. 1999 , Ehrnborg et al. 2003 ). A mouse model with liver-specific inducible inactivation of the IGF-I gene, using the Cre–LoxP conditional knockout system, has been developed (LI
Ida Marie Boisen, John Erik Nielsen, Lieve Verlinden, Mette Lorenzen, Rune Holt, Anja Pinborg, Christine Hjorth Andreassen, Anders Juul, Beate Lanske, Geert Carmeliet, and Martin Blomberg Jensen
-Aldrich. Germ cell-specific Casr knockdown mice Mice with specific knockdown of Casr in germ cells were generated using the inducible Cre-LoxP recombination system. Female Casr fl / fl mice ( Toka et al. 2012 ) were bred with Casr fl / fl male mice
