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Franca S Angeli and Richard P Shannon

worldwide epidemic, there is a growing demand for new treatments that not only control plasma glucose but also reduce macrovascular complications. Glucagon-like peptide 1 (GLP-1) is a peptide hormone synthesized in and secreted by enteroendocrine L cells in

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Thomas H Claus, Clark Q Pan, Joanne M Buxton, Ling Yang, Jennifer C Reynolds, Nicole Barucci, Michael Burns, Astrid A Ortiz, Steve Roczniak, James N Livingston, Kevin B Clairmont, and James P Whelan

Introduction Glucagon-like peptide-1 (GLP-1) is a potent endogenous modulator of insulin secretion that is released by the L-cells in the crypts of the jejunum and ileum in response to a meal ( Kieffer & Habener 1999 ). Its function

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Birgitte N Friedrichsen, Nicole Neubauer, Ying C Lee, Vivian K Gram, Niels Blume, Jacob S Petersen, Jens H Nielsen, and Annette Møldrup

Introduction The intestinal incretin hormones, glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released in response to fat and carbohydrate ingestion. Both peptides act to augment

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Leila Arbabi, Qun Li, Belinda A Henry, and Iain J Clarke

on GnRH secretion. Amongst other hormones, that regulate GnRH secretion, glucagon-like peptide-1 (GLP-1) from the gut and/or the brain has been shown to stimulate GnRH secretion, although the pathway for such an effect has not been elucidated. This

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Patricia Vázquez, Isabel Roncero, Enrique Blázquez, and Elvira Alvarez

Introduction Glucagon-like peptide-1(7–36)amide (GLP-1) is an intestinal peptide synthesised in L-cells. It is also produced in the brain ( Jin et al. 1988 , Kreymann et al. 1989 ), where it exerts some effects on

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Jun-ichi Eiki, Kaori Saeki, Norihiro Nagano, Tomoharu Iino, Mari Yonemoto, Yoko Takayenoki-Iino, Satoru Ito, Teruyuki Nishimura, Yoshiyuki Sato, Makoto Bamba, Hitomi Watanabe, Kaori Sasaki, Sumika Ohyama, Akio Kanatani, Toshio Nagase, and Toshihiko Yada

Introduction Glucagon-like peptide-1 (GLP-1) is a hormone secreted from enteroendocrine L-cells, and is well recognized as an incretin that induces insulin secretion in a glucose-dependent manner ( Drucker 2006 ). The functions of GLP-1 have been

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Can Liu, Mian Zhang, Meng-yue Hu, Hai-fang Guo, Jia Li, Yun-li Yu, Shi Jin, Xin-ting Wang, Li Liu, and Xiao-dong Liu

, it is noteworthy that local high concentration of ginsenosides in intestine may interact with intestinal epithelium, where numerous endocrine cells are located. Glucagon-like peptide-1 (GLP1), secreted by enteroendocrine L-cells, is one of the most

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Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, and Moon-Kyu Lee

Introduction Glucagon-like peptide (GLP)-1 is an intestinal hormone that exerts its effects in the regulation of glucose metabolism, the stimulation of pancreatic insulin secretion, proinsulin gene expression, and the proliferation and anti

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B D Green, N Irwin, V A Gault, C J Bailey, F P M O’Harte, and P R Flatt

Introduction The incretin hormone glucagon-like peptide-1 (GLP-1) has potent insulinotropic effects on pancreatic β-cells, and further promotes glucose lowering by enhancing glucose uptake and glyconeogenesis in peripheral tissues

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Colin W Hay, Elaine M Sinclair, Giovanna Bermano, Elaine Durward, Mohammad Tadayyon, and Kevin Docherty

Introduction Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by the enteroendocrine L-cells of the small intestine in response to food intake ( Kieffer & Habener 1999 , Drucker 2001 ). GLP-1 plays an important role in