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Qin Yin Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China

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Jun Gu Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China

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Pengju Ren Department of Orthopedics, The Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China

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Zhiqiang Guan Department of Dermatology, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu, China

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Yongxiang Wang Department of Orthopedics, Clinical Medical College, Yangzhou University, Yangzhou, China
Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou, China

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Ruijun Bai Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China

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Yu Liu Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China

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treatment - a systematic approach . Osteoarthritis and Cartilage 16 533 – 541 . ( https://doi.org/10.1016/j.joca.2008.01.002 ) Song S Lou Y Mao Y Wen X Fan M He Z Shen Y Wen C & Shao T 2022 Alteration of gut microbiome and correlated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0330
Volume/Issue:
Volume 261: Issue 2
Restricted access
Jitendra Vishwakarma Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Keerti Gupta Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Juhi Mishra Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Asmita Garg Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Rafat Malik Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Amit Kashyap Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Manoj Shukla Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India

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Dhirendra Singh Central Pathology Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR–IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Sanghamitra Bandyopadhyay Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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)- and methimazole (MZ)-treated PND0, PND08, PND16, and PND60 male and female rats were isolated. (B and C) Representative Western blots and densitometry, relative to (Rel.) CT0, of LC3B-II (B) and Beclin-1 (C) normalized with β-actin. *** P < 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0338
Volume/Issue:
Volume 257: Issue 1
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Marlise Guerrero Schimpf Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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María M Milesi Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Enrique H Luque Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Jorgelina Varayoud Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Physiology (Santa Fe, Argentina) and housed in a controlled environment (22°C ± 2°C; lights on from 06:00 to 20:00 h) in stainless steel cages with sterile pine wood shavings as bedding. Rats had free access to pellet laboratory chow (16-014007 Rat-Mouse Diet

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0207
Volume/Issue:
Volume 239: Issue 2
Free access
Kristen E Syring Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

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Karin J Bosma Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

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Slavina B Goleva Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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Kritika Singh Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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James K Oeser Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

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Christopher A Lopez Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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Eric P Skaar Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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Owen P McGuinness Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

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Lea K Davis Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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David R Powell Lexicon Pharmaceuticals Incorporated, 8800 Technology Forest Place, The Woodlands, Texas

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Richard M O’Brien Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

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association between demographics, SLC30A8 genotype, and human islet content of zinc, cadmium, copper, iron, manganese and nickel . Scientific Reports 7 473 . ( https://doi.org/10.1038/s41598-017-00394-3 ) Xu G Kang D Zhang C Lou H Sun C Yang

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0138
Volume/Issue:
Volume 246: Issue 2
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Nan Yang Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Giorgio Caratti Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Louise M Ince Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Toryn M Poolman Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Peter J Trebble Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Cathy M Holt Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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David W Ray Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Laura C Matthews Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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ApoE −/− mice have been described previously ( Plump et al . 1992 ). Transgenic and WT (C57BL/6) mice were routinely housed in 12 h light:12 h darkness (L:D) cycles with ad libitum access to food and water in a pathogen-free animal facility at the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0456
Volume/Issue:
Volume 223: Issue 2
Open access
Amy Warner AstraZeneca, Center of Brain, CVMD IMED, Pepparedsleden 1, 43183 Mölndal, Sweden

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Jens Mittag AstraZeneca, Center of Brain, CVMD IMED, Pepparedsleden 1, 43183 Mölndal, Sweden

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additional thermogenesis will cease as soon as the individual returns to the usual thermoneutral environment, around 22 °C for clothed humans. This was clearly demonstrated in a recent study, where BAT was activated by cold exposure (15–16 °C) for 6 h daily

Article Type:
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DOI:
https://doi.org/10.1530/JOE-15-0408
Volume/Issue:
Volume 228: Issue 1
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José Edgar Nicoletti-Carvalho
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Tatiane C Araújo Nogueira
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Renata Gorjão Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

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Carla Rodrigues Bromati
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Tatiana S Yamanaka
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Antonio Carlos Boschero Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

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Licio Augusto Velloso Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

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Rui Curi
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Gabriel Forato Anhê Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Physiology and Biophysics, Internal Medicine, Pharmacology, Faculty of Medical Sciences, State University of Campinas, Prof. Lineu Prestes Ave #1524. ICB 1- Room 125, 05508-900 Sao Paulo, SP, Brazil

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Silvana Bordin
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-unrevealed mechanism, but the increase in c-Jun N-terminal kinase activation and C/EBP homologous protein (CHOP) expression is likely to be the essential step ( Kharroubi et al . 2004 , Akerfeldt et al . 2008 ). Great attention is being paid to IL6 produced by

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0356
Volume/Issue:
Volume 206: Issue 2
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Jennifer H Stern Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Gordon I Smith Center for Human Nutrition, Washington University School of Medicine, Saint Louis, Missouri, USA

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Shiuwei Chen Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Roger H Unger Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Samuel Klein Center for Human Nutrition, Washington University School of Medicine, Saint Louis, Missouri, USA

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Philipp E Scherer Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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. Materials and methods Animal studies All studies were conducted in male wildtype C57BL/6J mice bred in-house at UT Southwestern Medical Center. Mice were maintained on a 12-h light/12-h darkness cycle and housed 3–5 mice per cage at least 1 week prior

Article Type:
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DOI:
https://doi.org/10.1530/JOE-19-0201
Volume/Issue:
Volume 243: Issue 2
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Li Juan He Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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Min Liang Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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Fan Fan Hou Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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Zhi Jian Guo Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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Di Xie Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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Xun Zhang Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, People's Republic of China

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of P. scrophulariiflora (2 kg, Tongrentang Group Co., Beijing, China) were ground and extracted with hot ethanol (60 °C, 500 ml, 12 h) five times. Ethanol was removed in vacuo and the residues (478 g) were dried in 60 °C for 12 hours. HPLC

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0481
Volume/Issue:
Volume 200: Issue 3
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Carolina Gaudenzi Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Karen R Mifsud Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Johannes M H M Reul Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Endocrinology 15 1586 – 1598 . ( https://doi.org/10.1210/mend.15.9.0689 ) Zhou HL Hinman MN Barron VA Geng C Zhou G Luo G Siegel RE & Lou H 2011 Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an

Article Type:
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DOI:
https://doi.org/10.1530/JOE-22-0293
Volume/Issue:
Volume 258: Issue 2
Open access