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T’ng Choong Kwok University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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Roland H Stimson University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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-FDG following 1 h of cold exposure. Human BAT depots are located in the supraclavicular, axillary, paraspinal and peri-renal regions, as demonstrated by substantial 18 F-FDG uptake. (B) BAT thermogenesis is activated by the sympathetic nervous system (SNS

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0017
Volume/Issue:
Volume 259: Issue 1
Open access
Ricardo J Samms School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Michelle Murphy School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Maxine J Fowler School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Scott Cooper School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Paul Emmerson School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Tamer Coskun School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Andrew C Adams School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Alexei Kharitonenkov School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Francis J P Ebling School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Kostas Tsintzas School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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additional weight. Even in long-term high-fat diet studies where some increase in food intake can be observed in Siberian hamsters, this does not result in weight gain, rather the animals increase thermogenesis via increased sympathetic nervous system (SNS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0334
Volume/Issue:
Volume 227: Issue 1
Free access
Antonius Plagge
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Gavin Kelsey Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

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Emily L Germain-Lee Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

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obesity, increased body weight, hyperlipidaemia, hyperglycaemia, glucose intolerance, hyperinsulinaemia, insulin resistance, reduced energy expenditure (hypometabolic) •Variable mental retardation and neurological symptoms •Reduced SNS

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0544
Volume/Issue:
Volume 196: Issue 2
Free access
Carsten T Herz Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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Florian W Kiefer Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria

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A; PKG: protein kinase G; POMC, pro-opiomelanocortin; PTH, parathyroid hormone; PTHR, parathyroid hormone receptor; PTHRP, parathyroid hormone-related peptide; SAM, sympathetic neuron-associated macrophage; SkM, skeletal muscle; SNS, sympathetic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0598
Volume/Issue:
Volume 241: Issue 3
Free access