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Michela Rossi Bone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Giulia Battafarano Bone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Viviana De Martino Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University, Rome, Italy

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Alfredo Scillitani Endocrinology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, Foggia, Italy

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Salvatore Minisola Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University, Rome, Italy

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Andrea Del Fattore Bone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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Introduction In healthy skeleton, the bone structure is maintained by the balanced relationship between osteoblasts and osteoclasts. These cells are responsible for the bone remodelling that begins with the recruitment and activation of bone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0285
Volume/Issue:
Volume 248: Issue 2
Free access
Vikte Lionikaite Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Karin L Gustafsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Anna Westerlund Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Sara H Windahl Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Antti Koskela Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland

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Juha Tuukkanen Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland

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Helena Johansson Institute for Health and Aging, Catholic University of Australia, Melbourne, Australia

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Claes Ohlsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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H Herschel Conaway Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Petra Henning Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Ulf H Lerner Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Wiseman et al. 2017 ). In humans, increased vitamin A consumption and elevated serum retinol levels have been associated with increased bone fragility and fracture risk ( Melhus et al. 1998 , Whiting & Lemke 1999 , Feskanich et al. 2002

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0316
Volume/Issue:
Volume 239: Issue 3
Open access
Louise Grahnemo Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Caroline Jochems Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Annica Andersson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Cecilia Engdahl Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Claes Ohlsson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Ulrika Islander Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Hans Carlsten Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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glucocorticoids is associated with several adverse side effects such as bone loss ( Silverman & Lane 2009 ). Although the results of most studies indicate that glucocorticoids have detrimental effects on bone, data are conflicting due to underlying inflammatory

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0508
Volume/Issue:
Volume 224: Issue 1
Open access
Natalie K Y Wee Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia

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Thaísa F C de Lima Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia
Department of Genetics and Molecular Biology, University of Campinas, São Paulo, Brazil

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Narelle E McGregor Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia

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Emma C Walker Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia

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Ingrid J Poulton Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia

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Martha Blank Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia
Department of Medicine, The University of Melbourne, St. Vincent’s Hospital, Melbourne, Australia

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Natalie A Sims Bone Cell Biology and Disease Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia
Department of Medicine, The University of Melbourne, St. Vincent’s Hospital, Melbourne, Australia

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Introduction Bone strength is partially determined during cortical bone consolidation. This is a three-step process comprising coalescence of peripheral trabecular bone on the endocortical surface, a gradual transformation of the consolidated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0084
Volume/Issue:
Volume 255: Issue 1
Free access
Claes Ohlsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Petra Henning Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin H Nilsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Jianyao Wu Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin L Gustafsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Klara Sjögren Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Anna Törnqvist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Antti Koskela Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Fu-Ping Zhang Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Marie K Lagerquist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Matti Poutanen Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Juha Tuukkanen Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Ulf H Lerner Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Sofia Movérare-Skrtic Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Introduction Osteoporosis affects hundreds of millions of people worldwide and fragility fractures cause enormous problems particularly for postmenopausal women and older men ( Baron & Hesse 2012 ). Cortical bone is a key determinant of bone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0020
Volume/Issue:
Volume 237: Issue 2
Open access
Norihiko Kato Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Keiichiro Kitahara Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Susan R Rittling Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Kazuhisa Nakashima Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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David T Denhardt Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Hisashi Kurosawa Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Yoichi Ezura Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Masaki Noda Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan

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Introduction The number of patients with osteoporosis is constantly increasing in the world and this disease has become a major health issue. The increased fracture rate in osteoporotic elderly patients due to reduced bone mass is a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06917
Volume/Issue:
Volume 193: Issue 1
Free access
Stuart A Lanham Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, School of Medicine, University of Southampton, Southampton, UK

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Dominique Blache School of Agriculture and Environment, University of Western Australia, Crawley, Australia

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Richard O C Oreffo Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, School of Medicine, University of Southampton, Southampton, UK

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Abigail L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Alison J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Introduction Growth and development of long bones during late gestation are important for the normal functioning of the neonatal skeleton, especially in precocial species like sheep that stand and are mobile from birth. In normal and adverse

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0189
Volume/Issue:
Volume 252: Issue 1
Open access
David E Maridas Maine Medical Center Research Institute, Scarborough, Maine, USA

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Victoria E DeMambro Maine Medical Center Research Institute, Scarborough, Maine, USA

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Phuong T Le Maine Medical Center Research Institute, Scarborough, Maine, USA

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Kenichi Nagano Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Roland Baron Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Subburaman Mohan VA Loma Linda Healthcare System, Loma Linda, California, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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Introduction IGF signaling is a crucial pathway controlling muscle, fat and bone growth and is regulated by 6 binding proteins, IGFBP1–6. The IGF-binding proteins can enhance or inhibit IGF action locally ( Gustafsson et al . 1999 , Tahimic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0673
Volume/Issue:
Volume 233: Issue 1
Open access
Nava Chapnik
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Gili Solomon
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Yoni Genzer
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Ruth Miskin Robert H. Smith Faculty of Agriculture, Department of Biological Chemistry, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Arieh Gertler
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Oren Froy
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levels of ghrelin ( Speakman & Mitchell 2011 ). Previous studies have shown that CR during rapid skeletal growth is deleterious to both cortical and trabecular bone mass and architecture ( Devlin et al . 2010 ). In mice between the ages of 2.5 and 8

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0033
Volume/Issue:
Volume 217: Issue 3
Free access
Colin Farquharson Bone Biology Group, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK

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Katherine Staines Bone Biology Group, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK

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The skeleton is composed of bone and cartilage. These tissues are made of an exquisite assembly of functionally distinct cell populations and are required to support the structural, biochemical and mechanical integrity of the skeleton. The functions

Article Type:
Editorial
DOI:
https://doi.org/10.1530/JOE-11-0274
Volume/Issue:
Volume 211: Issue 2
Free access