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Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease . Diabetes and Metabolism 29 478 – 485 . ( https://doi.org/10.1016/s1262-3636(0770061-7 ) Donnelly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0270
Volume/Issue:
Volume 257: Issue 2
Open access
Rachel Botchlett Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Pinnacle Clinical Research, Live Oak, USA

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Shih-Lung Woo Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Mengyang Liu Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Ya Pei Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Xin Guo Department of Nutrition and Food Science, Texas A&M University, College Station, USA
Baylor College of Medicine, Houston, USA

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Honggui Li Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, USA

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fat metabolism. Although a major role of the liver under normal/healthy conditions is not to store fat, it is responsible for a significant amount of de novo lipogenesis, including esterification of dietary fatty acids derived from chylomicron

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0580
Volume/Issue:
Volume 233: Issue 3
Free access
Yu-Feng Zhao Prince Henry's Institute of Medical Research, Department of Physiology, School of Biomedical Sciences, PO Box 5152, Clayton, Victoria 3168, Australia
Prince Henry's Institute of Medical Research, Department of Physiology, School of Biomedical Sciences, PO Box 5152, Clayton, Victoria 3168, Australia

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Jianming Pei Prince Henry's Institute of Medical Research, Department of Physiology, School of Biomedical Sciences, PO Box 5152, Clayton, Victoria 3168, Australia

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Chen Chen Prince Henry's Institute of Medical Research, Department of Physiology, School of Biomedical Sciences, PO Box 5152, Clayton, Victoria 3168, Australia
Prince Henry's Institute of Medical Research, Department of Physiology, School of Biomedical Sciences, PO Box 5152, Clayton, Victoria 3168, Australia

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triphosphate-sensitive potassium channels from β cells and extrapancreatic tissues . Metabolism 49 3 – 6 . Haber EP Ximenes HM Procopio J Carvalho CR Curi R Carpinelli AR 2003 Pleiotropic effects of fatty acids on pancreatic β

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0105
Volume/Issue:
Volume 198: Issue 3
Free access
Jose A Viscarra
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Cory D Champagne School of Natural Sciences, Long Marine Laboratory, Department of Biology, University of California, 5200 North Lake Road, Merced, California 95348, USA

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Daniel E Crocker School of Natural Sciences, Long Marine Laboratory, Department of Biology, University of California, 5200 North Lake Road, Merced, California 95348, USA

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Rudy M Ortiz
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when metabolism has shifted to oxidation of fat). Adiponectin promotes insulin sensitivity in peripheral tissues by stimulating the removal of free fatty acids (FFA) from circulation and thus its decrease is another commonly used measure to gauge

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0017
Volume/Issue:
Volume 209: Issue 3
Free access
William WN Jr
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RB Ceddia
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R Curi
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Leptin directly increases the rate of exogenous glucose and fatty acids oxidation in isolated adipocytes. However, the effects of leptin on fatty acid metabolism in white adipose tIssue have not been examined in detail. Here, we report that in adipocytes incubated for 6 h in the presence of leptin (10 ng/ml), the insulin-stimulated de novo fatty acid synthesis was inhibited by 36% (P<0.05), while the exogenous oxidation of acetic and oleic acids was increased by 50% and 76% respectively. Interestingly, leptin did not alter the oxidation of intracellular fatty acids. Leptin-incubated cells presented a 16-fold increase in the incorporation of oleic acid into triglyceride (TG) and a 123% increase in the intracellular TG hydrolysis (as measured by free fatty acids release). Fatty acid-TG cycling was not affected by leptin. By employing fatty acids radiolabeled with (3)H and (14)C, we could determine the concomitant influx of fatty acids (incorporation of fatty acids into TG) and efflux of fatty acids (intracellular fatty acids oxidation and free fatty acids release) in the incubated cells. Leptin increased by 30% the net efflux of fatty acids from adipocytes. We conclude that leptin directly inhibits de novo synthesis of fatty acids and increases the release and oxidation of fatty acids in isolated rat adipocytes. These direct energy-dissipating effects of leptin may play an important role in reducing accumulation of fatty acids into TG of rat adipose cells.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1750735
Volume/Issue:
Volume 175: Issue 3
Free access
C G Walker Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M C Sugden Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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G F Gibbons Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M J Holness Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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mechanism by which glucose metabolism, in particular lipogenesis, is up-regulated in the PPARα null mice is not clear. Although rates of flux through the fatty acid pathway (measured in vivo by 3 H incorporation from 3 H 2 O, which measures total

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0205
Volume/Issue:
Volume 193: Issue 1
Free access
Virginia L Pszczolkowski Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Meghan K Connelly Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Vita Plus Corporation, Madison, Wisconsin, USA

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Adam D Beard Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Amara D Benn Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA

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Jimena Laporta Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Laura L Hernandez Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Sebastian I Arriola Apelo Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Ferrannini E & Defronzo RA 1989 Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance . Journal of Clinical Investigation 84 205 – 213 . ( https://doi.org/10.1172/JCI114142

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0280
Volume/Issue:
Volume 257: Issue 3
Restricted access
Andre Sarmento-Cabral Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Mercedes del Rio-Moreno Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Mari C Vazquez-Borrego Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Mariyah Mahmood Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Elena Gutierrez-Casado Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Natalie Pelke Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Grace Guzman Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA

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Papasani V Subbaiah Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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Shoshana Yakar Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA

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Rhonda D Kineman Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago and Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA

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. 2009 , Nordstrom et al. 2013 , List et al. 2014 , Liu et al. 2016 , Corbit et al. 2018 ). These changes in systemic metabolic function are thought to shift the flux of glucose and non-esterified fatty acids (NEFA) to the liver, thus

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0326
Volume/Issue:
Volume 248: Issue 1
Restricted access
Jung-Yoon Heo Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea
Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea

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Ji-Eun Kim Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea
Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea

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Yongwook Dan Weinberg College, Northwestern University, Evanston, Illinois, USA

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Yong-Woon Kim Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea

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Jong-Yeon Kim Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea

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Kyu Hyang Cho Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea

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Young Kyung Bae Department of Pathology, College of Medicine, Yeungnam University, Daegu, Korea

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Seung-Soon Im Department of Physiology, Keimyung University School of Medicine, Daegu, Korea

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Kwang-Hyeon Liu College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea

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In-Hwan Song Department of Anatomy, College of Medicine, Yeungnam University, Daegu, Korea

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Jae-Ryong Kim Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea
Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea

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In-Kyu Lee Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea

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So-Young Park Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea
Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea

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involved in lipid metabolism in clusterin KO and wild-type mice fed a control diet. The mRNA levels of Cd36, Fabp1, Fabp3, Slc27a2 and Slc27a4, which are genes involved in fatty acid transportation, were not significantly different between wild-type and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0453
Volume/Issue:
Volume 237: Issue 2
Free access
Ricardo J Samms School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Michelle Murphy School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Maxine J Fowler School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Scott Cooper School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Paul Emmerson School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Tamer Coskun School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Andrew C Adams School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Alexei Kharitonenkov School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Francis J P Ebling School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Kostas Tsintzas School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Introduction Fibroblast growth factor 21 (FGF21) is an endocrine member of the fibroblast growth factor superfamily that plays a key role in the regulation of carbohydrate and fatty acid metabolism ( Kharitonenkov & Adams 2014 ). The primary

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0334
Volume/Issue:
Volume 227: Issue 1
Free access