differentially regulated by pregnancy (>1.5-fold change in expression, P <0.01). As the genes for GPCRs tend to be underrepresented in the global RNA expression analyses, potentially leading to missed targets ( Fredriksson & Schioth 2005 ), further studies were
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B T Layden, V Durai, M V Newman, A M Marinelarena, C W Ahn, G Feng, S Lin, X Zhang, D B Kaufman, N Jafari, G L Sørensen, and W L Lowe Jr
Tatiana Dorfman, Yulia Pollak, Rima Sohotnik, Arnold G Coran, Jacob Bejar, and Igor Sukhotnik
activates T-cell factor (TCF) and lymphoid enhancer factor to regulate the expression of Wnt target genes ( Schinner et al . 2009 ). Formation of a β-catenin/Tcf4 complex results in the direct upregulation of c- Myc , which in turn represses p21CIP1/WAF1 by
L Johnsen, A H Kongsted, and M O Nielsen
tissues and regulate oxygen consumption and overall metabolic rate. THs increase RNA synthesis of target genes and increase mitochondrial oxidation. There are reports of altered thyroid function associated with both development of the metabolic syndrome
Juan Sun, Liqun Mao, Hongyan Yang, and Decheng Ren
Shostak A , et al . 2010 Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain . Diabetes 59 3090 – 3098 . ( https://doi.org/10.2337/db10-0624 ) 10.2337/db10-0624 20802254 Wittenberg
Ying Zhang, Nan Meng, Haili Bao, Yufei Jiang, Ningjie Yang, Kejia Wu, Jinxiang Wu, Haibin Wang, Shuangbo Kong, and Yuanzhen Zhang
by the PGR gene), and the pleiotropic action of P 4 mainly relies on PR signaling that occurs in a cell type-specific manner. Endometrial stromal cells, which are principal targets for P 4 in the uterus, undergo a dynamic morphological
Richard C Lindsey, Catrina Godwin, and Subburaman Mohan
mechanism by which the TRs mediate the effects of TH is by acting as nuclear receptors, ligand-inducible transcription factors which regulate the expression of target genes. However, recent studies have determined that TH can exert nongenomic effects in
Ellen H Stolte, Aurélia F de Mazon, Karen M Leon-Koosterziel, Maria Jesiak, Nic R Bury, Armin Sturm, Huub F J Savelkoul, B M Lidy Verburg van Kemenade, and Gert Flik
mineralocorticoid (MR) receptors) that mediate their actions in the diverse targets and that define which genes will be activated or repressed. Interrenal cells of teleostean fishes produce cortisol as the major steroid; in addition, deoxycorticosterone (DOC; a
Cristina Mora, Cristina Pintado, Blanca Rubio, Lorena Mazuecos, Virginia López, Alejandro Fernández, Aurora Salamanca, Brenda Bárcena, Teresa Fernández-Agulló, Carmen Arribas, Nilda Gallardo, and Antonio Andrés
heart. Knowing that PPARα repressed, whereas PPARβ/δ activated, target genes involved in heart glucose metabolism ( Burkat et al. 2007 ), we hypothesized that central leptin infusion may protect the heart from lipid accumulation through the different
Georgia Balsevich, Andres Uribe, Klaus V Wagner, Jakob Hartmann, Sara Santarelli, Christiana Labermaier, and Mathias V Schmidt
identifying molecular targets involved in the interplay between DIO and chronic stress. Emerging literature on possible mechanisms underlying stress-induced psychiatric disorders have identified the Fkbp5 gene, encoding the FK506-binding protein 51 (FKBP51
J-W Jeong, K Y Lee, J P Lydon, and F J DeMayo
), calbindin-D9K ( Nie et al. 2000 ), Indian hedgehog ( Ihh ) ( Takamoto et al. 2002 ), hypoxia-inducible factor 1 ( Hif1a ; Daikoku et al. 2003 ) and immune-responsive gene 1 ( Irg1 ) ( Cheon et al. 2003 ). These target genes have been identified by
