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Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Introduction Glucocorticoids are adrenal steroid hormones engaged in a myriad of functions including adaptation to stress, circadian function and immune regulation. Glucocorticoids also mediate quintessential processes in metabolic physiology

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
Free access
Kevin H Tsai ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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Mark S Cooper ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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Introduction Despite the introduction of a range of biological therapies aimed at specific aspects of the immune response, glucocorticoids are still widely used for their broad and potent therapeutic effects. Despite considerable efforts in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0289
Volume/Issue:
Volume 258: Issue 3
Free access
Kerryn M Taylor Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa

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David W Ray Manchester Centre for Nuclear Hormone Research and Disease, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom

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Paula Sommer Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa

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matter ( Semenova et al. 2015 ). The driver mutations for NSCLC particularly have been well described, and mutation testing can be used for patient stratification and prescription of targeted therapy ( Pao & Girard 2011 ). The glucocorticoid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0496
Volume/Issue:
Volume 229: Issue 1
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A McMaster Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular

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T Chambers Medicine, Faculty of Life Sciences, Centre for Molecular

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Q-J Meng Medicine, Faculty of Life Sciences, Centre for Molecular

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S Grundy Medicine, Faculty of Life Sciences, Centre for Molecular

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A S I Loudon Medicine, Faculty of Life Sciences, Centre for Molecular

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R Donn Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular

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D W Ray Medicine, Faculty of Life Sciences, Centre for Molecular

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Introduction Glucocorticoid hormones exert a wide diversity of effects in target tissues. Their activity has been typically explored using a limited number of timed end points, both in vivo and in vitro , and using such approaches a variety of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0639
Volume/Issue:
Volume 197: Issue 2
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David P Macfarlane Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Shareen Forbes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Brian R Walker Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Introduction Endogenous glucocorticoids are steroid hormones secreted from the adrenal cortex under the influence of the hypothalamic–pituitary–adrenal (HPA) axis that constitutes an integral component of the response to stress. Corticosterone is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0054
Volume/Issue:
Volume 197: Issue 2
Free access
Julia N C Toews Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Geoffrey L Hammond Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Victor Viau Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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themselves hormone-dependent, and are directly or indirectly controlled by factors such as growth hormone (GH), insulin-like growth factor 1 (IGF1), thyroid hormones and steroids; and in particular, the glucocorticoid hormones that govern hepatic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0286
Volume/Issue:
Volume 248: Issue 1
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Henrik Oster Institute of Neurobiology, University of Lübeck, Lübeck, Germany

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adrenal medulla ( Wong 2006 ). This fast/acute response is trailed by an activation of the multi-step hypothalamus–pituitary–adrenal (HPA) axis and the release of glucocorticoids (GCs) – cortisol in humans and other primates, corticosterone in rodents

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0124
Volume/Issue:
Volume 247: Issue 1
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Rick van der Geest Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Ronald J van der Sluis Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Albert K Groen Departments of Pediatrics and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands

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Miranda Van Eck Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Menno Hoekstra Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands

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Introduction Glucocorticoids, members of the steroid hormone superfamily, are secreted into the bloodstream by the adrenals in response to stress-induced activation of the hypothalamus–pituitary–adrenal axis. Through an interaction with their

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0079
Volume/Issue:
Volume 242: Issue 2
Free access
S Khan Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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D E W Livingstone Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK

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A Zielinska College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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C L Doig Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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D F Cobice Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L Esteves Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J T Y Man Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J R Seckl Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L MacKay SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK

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S P Webster Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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G G Lavery Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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K E Chapman Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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B R Walker Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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R Andrew Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Introduction 11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) generates active 11-hydroxy glucocorticoids (cortisol (human), corticosterone (rodent and human)) from intrinsically inert 11-keto steroids (cortisone, 11-dehydrocorticosterone (11DHC

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0034
Volume/Issue:
Volume 258: Issue 3
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Chad D Osterlund Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Vanessa Thompson Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Laura Hinds Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Robert L Spencer Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Introduction Corticotropin-releasing hormone (CRH) neurons of the hypothalamic–pituitary–adrenal (HPA) axis integrate stress-dependent changes in neural input and direct negative feedback effects of glucocorticoids ( Dallman et al . 1987

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0365
Volume/Issue:
Volume 220: Issue 1
Free access