Search Results
Meng Guo
Meng Guo
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Meng Guo in
Google Scholar
PubMed
Search for other papers by Meng Guo in
Google Scholar
PubMed
Yuna Li
Yuna Li
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Yuna Li in
Google Scholar
PubMed
Search for other papers by Yuna Li in
Google Scholar
PubMed
Yan Wang
Yan Wang
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Yan Wang in
Google Scholar
PubMed
Search for other papers by Yan Wang in
Google Scholar
PubMed
Zhenkun Li
Zhenkun Li
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Zhenkun Li in
Google Scholar
PubMed
Search for other papers by Zhenkun Li in
Google Scholar
PubMed
Xiaohong Li
Xiaohong Li
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Xiaohong Li in
Google Scholar
PubMed
Search for other papers by Xiaohong Li in
Google Scholar
PubMed
Peikun Zhao
Peikun Zhao
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Peikun Zhao in
Google Scholar
PubMed
Search for other papers by Peikun Zhao in
Google Scholar
PubMed
Changlong Li
Changlong Li
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Changlong Li in
Google Scholar
PubMed
Search for other papers by Changlong Li in
Google Scholar
PubMed
Jianyi Lv
Jianyi Lv
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Jianyi Lv in
Google Scholar
PubMed
Search for other papers by Jianyi Lv in
Google Scholar
PubMed
Xin Liu
Xin Liu
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Xin Liu in
Google Scholar
PubMed
Search for other papers by Xin Liu in
Google Scholar
PubMed
Xiaoyan Du
Xiaoyan Du
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Xiaoyan Du in
Google Scholar
PubMed
Search for other papers by Xiaoyan Du in
Google Scholar
PubMed
Zhenwen Chen
Zhenwen Chen
School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China
Search for other papers by Zhenwen Chen in
Google Scholar
PubMed
Search for other papers by Zhenwen Chen in
Google Scholar
PubMed
Introduction As a major metabolic tissue, skeletal muscle constitutes 40% of the total body mass and plays a predominant role in postprandial glucose disposal in humans ( DeFronzo et al. 1981 ). Insulin resistance in skeletal muscle is an
Mark E Cleasby
Mark E Cleasby
Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK
Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Pauline M Jamieson
Pauline M Jamieson
Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Philip J Atherton
Philip J Atherton
Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK
Search for other papers by Philip J Atherton in
Google Scholar
PubMed
Search for other papers by Philip J Atherton in
Google Scholar
PubMed
, of which the significant majority would be of >40 years old ( IDF 2013 ). Of these, 90% suffer from type 2 diabetes (T2D), which is characterised by both β-cell failure and resistance to the actions of insulin at the tissue level (insulin resistance
Xiao-Bing Cui
Xiao-Bing Cui
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Search for other papers by Xiao-Bing Cui in
Google Scholar
PubMed
Search for other papers by Xiao-Bing Cui in
Google Scholar
PubMed
Jun-Na Luan
Jun-Na Luan
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Search for other papers by Jun-Na Luan in
Google Scholar
PubMed
Search for other papers by Jun-Na Luan in
Google Scholar
PubMed
Jianping Ye
Jianping Ye
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Search for other papers by Jianping Ye in
Google Scholar
PubMed
Search for other papers by Jianping Ye in
Google Scholar
PubMed
Shi-You Chen
Shi-You Chen
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Search for other papers by Shi-You Chen in
Google Scholar
PubMed
Department of Physiology and Pharmacology, Renmin Hospital, Antioxidant and Gene Regulation Laboratory, University of Georgia, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA
Search for other papers by Shi-You Chen in
Google Scholar
PubMed
, and metabolic energy balance ( Chatterjee et al . 2014 ). Although the underlying mechanism is not fully understood, adipose tissue inflammation has been acknowledged as a critical link between obesity and insulin resistance and type 2 diabetes, and
Yujiao Dai
Yujiao Dai
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yujiao Dai in
Google Scholar
PubMed
Search for other papers by Yujiao Dai in
Google Scholar
PubMed
Peng Hao
Peng Hao
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Peng Hao in
Google Scholar
PubMed
Search for other papers by Peng Hao in
Google Scholar
PubMed
Zhimei Sun
Zhimei Sun
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Zhimei Sun in
Google Scholar
PubMed
Search for other papers by Zhimei Sun in
Google Scholar
PubMed
Zhiyi Guo
Zhiyi Guo
School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Zhiyi Guo in
Google Scholar
PubMed
Search for other papers by Zhiyi Guo in
Google Scholar
PubMed
Hong Xu
Hong Xu
School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Hong Xu in
Google Scholar
PubMed
Search for other papers by Hong Xu in
Google Scholar
PubMed
Lihui Xue
Lihui Xue
Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Lihui Xue in
Google Scholar
PubMed
Search for other papers by Lihui Xue in
Google Scholar
PubMed
Hongyu Song
Hongyu Song
Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Hongyu Song in
Google Scholar
PubMed
Search for other papers by Hongyu Song in
Google Scholar
PubMed
Yida Li
Yida Li
Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yida Li in
Google Scholar
PubMed
Search for other papers by Yida Li in
Google Scholar
PubMed
Shuang Li
Shuang Li
Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Shuang Li in
Google Scholar
PubMed
Search for other papers by Shuang Li in
Google Scholar
PubMed
Mingming Gao
Mingming Gao
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Mingming Gao in
Google Scholar
PubMed
Search for other papers by Mingming Gao in
Google Scholar
PubMed
Teng Si
Teng Si
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Teng Si in
Google Scholar
PubMed
Search for other papers by Teng Si in
Google Scholar
PubMed
Yuxin Zhang
Yuxin Zhang
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yuxin Zhang in
Google Scholar
PubMed
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yuxin Zhang in
Google Scholar
PubMed
Yajuan Qi
Yajuan Qi
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yajuan Qi in
Google Scholar
PubMed
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China
Search for other papers by Yajuan Qi in
Google Scholar
PubMed
reverse its progression. However, if Yap is involved in liver fibrosis induced by insulin resistance (IR) has not been reported. In this study, mouse liver fibrosis was induced by IR using HFD stimulation, and the liver YAP pathway and insulin pathway
Eliana H Akamine
Eliana H Akamine
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Eliana H Akamine in
Google Scholar
PubMed
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Eliana H Akamine in
Google Scholar
PubMed
Anderson C Marçal
Anderson C Marçal
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Anderson C Marçal in
Google Scholar
PubMed
Search for other papers by Anderson C Marçal in
Google Scholar
PubMed
João Paulo Camporez
João Paulo Camporez
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by João Paulo Camporez in
Google Scholar
PubMed
Search for other papers by João Paulo Camporez in
Google Scholar
PubMed
Mara S Hoshida
Mara S Hoshida
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Mara S Hoshida in
Google Scholar
PubMed
Search for other papers by Mara S Hoshida in
Google Scholar
PubMed
Luciana C Caperuto
Luciana C Caperuto
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Luciana C Caperuto in
Google Scholar
PubMed
Search for other papers by Luciana C Caperuto in
Google Scholar
PubMed
Estela Bevilacqua
Estela Bevilacqua
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Estela Bevilacqua in
Google Scholar
PubMed
Search for other papers by Estela Bevilacqua in
Google Scholar
PubMed
Carla R O Carvalho
Carla R O Carvalho
Departments of, Physiology and Biophysics, Pharmacology, Cell and Development of Biology, Department of Biological Sciences, Institute of Biomedical Sciences
Search for other papers by Carla R O Carvalho in
Google Scholar
PubMed
Search for other papers by Carla R O Carvalho in
Google Scholar
PubMed
the development of the syndrome in susceptible women ( Pasquali & Casimirri 1993 , Legro 2000 , Metwally et al . 2007 ). The major factor underlying the adverse metabolic consequences of obesity is believed to be insulin resistance. The reduction in
Ya Liu
Ya Liu
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Ya Liu in
Google Scholar
PubMed
Search for other papers by Ya Liu in
Google Scholar
PubMed
Xiaoqing Zhou
Xiaoqing Zhou
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Xiaoqing Zhou in
Google Scholar
PubMed
Search for other papers by Xiaoqing Zhou in
Google Scholar
PubMed
Ye Xiao
Ye Xiao
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Ye Xiao in
Google Scholar
PubMed
Search for other papers by Ye Xiao in
Google Scholar
PubMed
Changjun Li
Changjun Li
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Changjun Li in
Google Scholar
PubMed
Search for other papers by Changjun Li in
Google Scholar
PubMed
Yan Huang
Yan Huang
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Yan Huang in
Google Scholar
PubMed
Search for other papers by Yan Huang in
Google Scholar
PubMed
Qi Guo
Qi Guo
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Qi Guo in
Google Scholar
PubMed
Search for other papers by Qi Guo in
Google Scholar
PubMed
Tian Su
Tian Su
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Tian Su in
Google Scholar
PubMed
Search for other papers by Tian Su in
Google Scholar
PubMed
Lei Fu
Lei Fu
Department of Infectious Diseases, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Lei Fu in
Google Scholar
PubMed
Search for other papers by Lei Fu in
Google Scholar
PubMed
Liping Luo
Liping Luo
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
Search for other papers by Liping Luo in
Google Scholar
PubMed
Search for other papers by Liping Luo in
Google Scholar
PubMed
with type 2 diabetes mellitus (T2DM), as more than 70% of patients with T2DM have NAFLD ( Tilg et al. 2017 , Younossi et al. 2019 ). Both diseases share some common pathological features including hypertriglyceridaemia and insulin resistance
Marco Hatem-Vaquero
Marco Hatem-Vaquero
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Marco Hatem-Vaquero in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Marco Hatem-Vaquero in
Google Scholar
PubMed
Mercedes Griera
Mercedes Griera
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Mercedes Griera in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Mercedes Griera in
Google Scholar
PubMed
Andrea García-Jerez
Andrea García-Jerez
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Andrea García-Jerez in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Andrea García-Jerez in
Google Scholar
PubMed
Alicia Luengo
Alicia Luengo
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Alicia Luengo in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Alicia Luengo in
Google Scholar
PubMed
Julia Álvarez
Julia Álvarez
Endocrinology and Nutrition Department, Hospital Príncipe de Asturias, Madrid, Spain
Search for other papers by Julia Álvarez in
Google Scholar
PubMed
Search for other papers by Julia Álvarez in
Google Scholar
PubMed
José A Rubio
José A Rubio
Endocrinology and Nutrition Department, Hospital Príncipe de Asturias, Madrid, Spain
Search for other papers by José A Rubio in
Google Scholar
PubMed
Search for other papers by José A Rubio in
Google Scholar
PubMed
Laura Calleros
Laura Calleros
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Laura Calleros in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Laura Calleros in
Google Scholar
PubMed
Diego Rodríguez-Puyol
Diego Rodríguez-Puyol
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Biomedical Research Foundation and Nephrology Department, Hospital Príncipe de Asturias, Madrid, Spain
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Search for other papers by Diego Rodríguez-Puyol in
Google Scholar
PubMed
Biomedical Research Foundation and Nephrology Department, Hospital Príncipe de Asturias, Madrid, Spain
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Search for other papers by Diego Rodríguez-Puyol in
Google Scholar
PubMed
Manuel Rodríguez-Puyol
Manuel Rodríguez-Puyol
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Manuel Rodríguez-Puyol in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Manuel Rodríguez-Puyol in
Google Scholar
PubMed
Sergio De Frutos
Sergio De Frutos
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Sergio De Frutos in
Google Scholar
PubMed
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Search for other papers by Sergio De Frutos in
Google Scholar
PubMed
type 2 diabetes, MS and aging, GLUT4 expression is reduced in peripheral tissue, which may play a role in increasing insulin resistance ( Shepherd & Kahn 1999 , Gaster et al. 2001 , Zeyda & Stulnig 2009 ). Moreover, some medical therapies for type 2
Adina Maniu
Adina Maniu
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for other papers by Adina Maniu in
Google Scholar
PubMed
Search for other papers by Adina Maniu in
Google Scholar
PubMed
Graham W Aberdeen
Graham W Aberdeen
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for other papers by Graham W Aberdeen in
Google Scholar
PubMed
Search for other papers by Graham W Aberdeen in
Google Scholar
PubMed
Terrie J Lynch
Terrie J Lynch
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA
Search for other papers by Terrie J Lynch in
Google Scholar
PubMed
Search for other papers by Terrie J Lynch in
Google Scholar
PubMed
Jerry L Nadler
Jerry L Nadler
Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
Search for other papers by Jerry L Nadler in
Google Scholar
PubMed
Search for other papers by Jerry L Nadler in
Google Scholar
PubMed
Soon O K Kim
Soon O K Kim
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA
Search for other papers by Soon O K Kim in
Google Scholar
PubMed
Search for other papers by Soon O K Kim in
Google Scholar
PubMed
Michael J Quon
Michael J Quon
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for other papers by Michael J Quon in
Google Scholar
PubMed
Search for other papers by Michael J Quon in
Google Scholar
PubMed
Gerald J Pepe
Gerald J Pepe
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA
Search for other papers by Gerald J Pepe in
Google Scholar
PubMed
Search for other papers by Gerald J Pepe in
Google Scholar
PubMed
Eugene D Albrecht
Eugene D Albrecht
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for other papers by Eugene D Albrecht in
Google Scholar
PubMed
Search for other papers by Eugene D Albrecht in
Google Scholar
PubMed
action. Thus, mice lacking estrogen receptor α (ERα (ESR1)) exhibit insulin resistance within skeletal muscle and liver ( Bryzgalova et al . 2006 , Ribas et al . 2011 , Manrique et al . 2012 ). In humans and rodents, mutation of the aromatase gene
Julie Takada
Julie Takada
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Julie Takada in
Google Scholar
PubMed
Search for other papers by Julie Takada in
Google Scholar
PubMed
Miriam Helena Fonseca-Alaniz
Miriam Helena Fonseca-Alaniz
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Miriam Helena Fonseca-Alaniz in
Google Scholar
PubMed
Search for other papers by Miriam Helena Fonseca-Alaniz in
Google Scholar
PubMed
Tarcila Beatriz Ferraz de Campos
Tarcila Beatriz Ferraz de Campos
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Tarcila Beatriz Ferraz de Campos in
Google Scholar
PubMed
Search for other papers by Tarcila Beatriz Ferraz de Campos in
Google Scholar
PubMed
Sandra Andreotti
Sandra Andreotti
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Sandra Andreotti in
Google Scholar
PubMed
Search for other papers by Sandra Andreotti in
Google Scholar
PubMed
Amanda Baron Campana
Amanda Baron Campana
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Amanda Baron Campana in
Google Scholar
PubMed
Search for other papers by Amanda Baron Campana in
Google Scholar
PubMed
Maristela Okamoto
Maristela Okamoto
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Maristela Okamoto in
Google Scholar
PubMed
Search for other papers by Maristela Okamoto in
Google Scholar
PubMed
Cristina das Neves Borges-Silva
Cristina das Neves Borges-Silva
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Cristina das Neves Borges-Silva in
Google Scholar
PubMed
Search for other papers by Cristina das Neves Borges-Silva in
Google Scholar
PubMed
Ubiratan Fabres Machado
Ubiratan Fabres Machado
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Ubiratan Fabres Machado in
Google Scholar
PubMed
Search for other papers by Ubiratan Fabres Machado in
Google Scholar
PubMed
Fabio Bessa Lima
Fabio Bessa Lima
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil
Search for other papers by Fabio Bessa Lima in
Google Scholar
PubMed
Search for other papers by Fabio Bessa Lima in
Google Scholar
PubMed
metabolic syndrome, leading to a greater free fatty acid (FFA) flux, which inhibits insulin action in insulin-sensitive tissues ( Randle et al . 1963 ). Insulin resistance coupled with obesity triggers many metabolic abnormalities that increase
Richard R Almon
Richard R Almon
Search for other papers by Richard R Almon in
Google Scholar
PubMed
Search for other papers by Richard R Almon in
Google Scholar
PubMed
Debra C DuBois
Debra C DuBois
Search for other papers by Debra C DuBois in
Google Scholar
PubMed
Search for other papers by Debra C DuBois in
Google Scholar
PubMed
Jin Y Jin
Jin Y Jin
Search for other papers by Jin Y Jin in
Google Scholar
PubMed
Search for other papers by Jin Y Jin in
Google Scholar
PubMed
William J Jusko
William J Jusko
Search for other papers by William J Jusko in
Google Scholar
PubMed
Search for other papers by William J Jusko in
Google Scholar
PubMed
increased gluconeogenesis in the liver and kidney, net muscle-protein breakdown to provide gluconeogenic substrates, insulin resistance of peripheral tissues including skeletal muscle, and lipid mobilization. Glucocorticoids also suppress
