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Jie Wei Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Xia Sun Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yajie Chen Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yuanyuan Li
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Liqiong Song
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Zhao Zhou
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Bing Xu
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Yi Lin Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Shunqing Xu
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offspring of rats exposed to BPA fed on a HFD compared with controls fed on a HFD. Figure 2 The effect of BPA on hepatic energy metabolism in the liver. (A) mRNA expression of genes associated with lipogenesis, fatty acid oxidation, and gluconeogenesis. (B

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0356
Volume/Issue:
Volume 222: Issue 3
Free access
Nicole M Templeman Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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Søs Skovsø Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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Melissa M Page Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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Gareth E Lim Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

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James D Johnson Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
Institute for Personalized Therapeutic Nutrition, Vancouver, British Columbia, Canada

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storage in its major peripheral target tissues, primarily by stimulating: (1) glucose uptake in adipose tissue and muscle; (2) glycolysis and glycogen synthesis in muscle and liver; (3) lipogenesis in adipose tissue and liver and (4) protein synthesis in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0449
Volume/Issue:
Volume 232: Issue 3
Free access
Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Veronika Pražienková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Andrea Popelová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Barbora Mikulášková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jana Zemenová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
University of Chemistry and Technology, Prague, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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decreased de novo lipogenesis owing primarily to negative energy balance due to reduced food intake ( Maletinska et al . 2015 ). Finally, similar results were found in our following study demonstrating that a 2-week-long peripheral treatment of DIO

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0046
Volume/Issue:
Volume 230: Issue 2
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Rodrigo Martins Pereira Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Kellen Cristina da Cruz Rodrigues Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Chadi Pellegrini Anaruma Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Marcella Ramos Sant’Ana Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Thaís Dantis Pereira de Campos Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rodrigo Stellzer Gaspar Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Raphael dos Santos Canciglieri Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Diego Gomes de Melo Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Rania A Mekary Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA

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Adelino Sanchez Ramos da Silva School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Dennys Esper Cintra Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Eduardo Rochete Ropelle Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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José Rodrigo Pauli Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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Leandro Pereira de Moura Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil

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was assessed through analysis of the protein levels and mRNA of CPT1A. Coherently, fasting glycemia presented a positive correlation with hepatic lipogenesis, as assessed by the FAS (fatty acid synthase) content ( Fig. 4F and G , Bioinformatics

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0567
Volume/Issue:
Volume 241: Issue 1
Free access
Ken K Y Ho Centres for Health Research, Princess Alexandra Hospital, The University of Queensland and The Translation Research Institute, Brisbane, Queensland, Australia

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cost of storage? Indeed, lipogenesis was stimulated during prednisolone treatment ( Fig. 3B ) with the rate of lipid synthesis significantly correlated to energy expenditure after the meal ( Thuzar et al. 2017 ). In short, the enhancement of the non

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0240
Volume/Issue:
Volume 238: Issue 3
Free access
Li Zhao Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Chunfang Zhu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Meng Lu Research Center for Clinical Medicine, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Chi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Xiaomin Nie Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Buatikamu Abudukerimu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Kun Zhang Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Zhiyuan Ning Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Yi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Jing Cheng Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Fangzhen Xia Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Ningjian Wang Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Michael D Jensen Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA

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Yingli Lu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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percent excess (MPE). Lipidosis and lipogenesis in the liver and different fat depots were calculated by dividing the total concentrations of TG or the corresponding tissue mass by the radioactivity of the corresponding labeled TG, respectively ( Shadid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0374
Volume/Issue:
Volume 240: Issue 2
Free access
Helena A Walz Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Linda Härndahl Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Nils Wierup Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Emilia Zmuda-Trzebiatowska Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Fredrik Svennelid Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Vincent C Manganiello Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Thorkil Ploug Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Frank Sundler Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Eva Degerman Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Bo Ahrén Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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Lena Stenson Holst Department of Experimental Medical Science, Biomedical Centre, C11, Lund University, SE-221 84 Lund, Sweden
Pulmonary/Critical-Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
Department of Medical Physiology, the Panum Institute, DK-2200 Copenhagen, Denmark
Department of Clinical Sciences, Lund, Biomedical Centre, B11, Lund University, SE-221 84 Lund, Sweden

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]sucrose per ml and 1 mM unlabeled 2-deoxy- d -glucose and sucrose. After a 10-min exposure to the isotopes, muscles were immediately frozen in liquid nitrogen and stored at − 80 °C. Insulin-stimulated lipogenesis in white adipocytes

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06522
Volume/Issue:
Volume 189: Issue 3
Free access
Abigail Wolf Greenstein Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Biologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA

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Neena Majumdar Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Peng Yang Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Papasani V Subbaiah Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Rhonda D Kineman Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Cordoba-Chacon Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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and fibrosis) with TZDs reduces steatosis with variable effects on fibrosis ( Belfort et al . 2006 , Ratziu et al . 2008 , Sanyal et al . 2010 ). The reduction in steatosis is associated with a reduction in hepatic de novo lipogenesis (DNL

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0447
Volume/Issue:
Volume 232: Issue 1
Free access
A. H. Cincotta
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A. H. Meier
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ABSTRACT

Lipogenesis was determined at two times (07.00 and 16.00 h) during a 14-h daily photoperiod (08.00–22.00 h) in freshly prepared hamster hepatocytes with or without addition of insulin. The hamsters were pretreated for 5 days with bromocriptine (to inhibit prolactin secretion), bromocriptine and prolactin replacement, or control saline injections. Lipogenesis was determined by incorporation of [14C]acetate into total cell lipids over a 30-min interval. Lipogenesis was three times greater at 07.00 than at 16.00 h and insulin was effective in stimulating further lipogenesis only at 07.00 h. Bromocriptine pretreatment severely reduced incorporation of radiolabel at 07.00 h to levels comparable with controls at 16.00 h and completely inhibited the stimulatory effect of insulin at 07.00 h. Prolactin replacement in bromocriptine-treated hamsters reversed the inhibitory effect of bromocriptine on hepatocyte lipogenesis and promoted dramatic lipogenic responses to insulin at 07.00 h. These results indicate that insulin stimulates hepatic lipogenesis only during some portion of a day and that prolactin facilitates the lipogenic response.

J. Endocr. (1985) 106, 173–176

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.1060173
Volume/Issue:
Volume 106: Issue 2
Restricted access
Meng Guo School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Yuna Li School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Yan Wang School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Zhenkun Li School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Xiaohong Li School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Peikun Zhao School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Changlong Li School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Jianyi Lv School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Xin Liu School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Xiaoyan Du School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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Zhenwen Chen School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, People’s Republic of China

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-0051 . eEF1A2 inhibited lipogenesis and lipid use in insulin-resistant skeletal muscle To further uncover the involvement of eEF1A2 in insulin-resistant skeletal muscle, expression levels of the genes of lipogenesis and lipid lipolysis and oxidation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0051
Volume/Issue:
Volume 244: Issue 1
Restricted access