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. 2008 ). There is evidence for rare pancreatic progenitor cells in human and mouse islets capable of multi-lineage differentiation and which express insulin ( Smukler et al. 2011 ). Importantly, these cells demonstrate low/absent glucose-transporter 2

al. 2019 ) were conducted with male C57BL/6J or C57BL/6JRj mice (B6J), a commonly used mouse model to study the effects of diet-induced obesity and glucose intolerance. A limitation of using these mice for metabolic studies is a deficiency in

and cortisol in the developing fetus has been difficult to examine in conventional laboratory rodents, as rat and mouse adrenal glands do not express P450c17, and adrenal DHEA production is insignificant at any stage of life ( Van Weerden et al . 1992

signal during the LH surge is GnRH self-priming, and we have shown for rat gonadotropes that there is overlap of the self-priming pathway with activation of the progesterone receptor (PR; Waring & Turgeon 1992 , Turgeon & Waring 1994 ). For mouse

of how TSH regulates physiologically relevant adipose tissue. Materials and Methods Growth and maintenance of ES cells W9.5 ES cells were maintained on irradiated mouse embryonic feeder cells as previously described ( Lin et al . 2003 , Arufe et al

with the positron-emitting radionuclide 89 Zr in two normal rodent models and a humanized mouse model implanted with human peripheral blood mononuclear cells reported high tracer uptake and high estimated radiation-absorbed doses to adult human in the

describe the characterization of mouse 17β-HSD12. We show that, similar to 17β-HSD1, mouse 17β-HSD12 is also able to catalyze the transformation of C19-steroids, which is in contrast with the corresponding human enzymes that are selective for estrogenic

function in MIN6 cells. Their results suggest that mouse T1R3 (mT1R3) is not totally insensitive to lactisole. Nevertheless, since their results are apparently contradictory to previous reports ( Johnson et al . 1994 , Jiang et al . 2005 ), investigators

number of implantation sites in mice ( Huang et al . 2004 ). Prss23 is strongly expressed in uterine luminal epithelium during mouse preimplantation period, and Prss35 is mainly expressed in subluminal stromal cells on days 5 and 6 of pregnancy ( Diao

. 2008 , Ronnett et al . 2009 ). Based on its role in the regulation of food intake, the hypothalamus has been extensively studied in an animal model of anorexia, the anx/anx mouse ( Son et al . 1994 , Broberger et al . 1997 , 1998 , 1999