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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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a cellular increase in cAMP concentrations would be sufficient to downregulate visfatin mRNA. Cholera toxin activates G S -proteins by ADP-ribosylation whereas forskolin is a direct activator of adenylyl cyclase. 3T3-L1 adipocytes were treated with
Animal Endocrine Clinic, Department of Clinical Sciences, 21 West 100th Street, New York, New York 10025, USA
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subgroups regulate adenylyl cyclase activity, which in turn controls the formation of cAMP ( Wettschureck & Offermanns 2005 ). The G s proteins are stimulatory to adenylyl cyclase, while the G i proteins are inhibitory. Adenylyl cyclase activity and cAMP
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Biomolecular Science Institute, Florida International University, Miami, Florida, USA
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done to further characterize INSL3/RXFP2 signaling and functions. Mechanisms of INSL3 binding and activation of RXFP2 INSL3 treatment of HEK293T cells transfected with RXFP2 causes activation of the classical adenylyl cyclase (AC) pathway via
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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). Gα S , encoded by the GNAS gene located on human chromosome 20 ( Gnas on chromosome 2 in mice), is widely expressed and known for its activation of adenylyl cyclases to generate cAMP with a myriad of effects on cell metabolism and gene expression
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, leading to the simultaneous stimulation of distinct signaling pathways. While the ACTH receptor interacts preferentially with stimulatory G-protein (G s ) to stimulate adenylyl cyclase (AC), coupling to inhibitory G-protein (G i ) has also been reported
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pathway responsible for reduced gene transcription following activation of the dopamine receptor results in the inhibition of adenylyl cyclase ( Taussig & Gilman 1995 ), decrease in cAMP production and suppression of activated PKA ( Diamond et al . 1999
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-coupled DP, EP 2 , EP 4 and IP receptors mediate uterine relaxation via adenylyl cyclase and cyclic AMP (cAMP). By contrast, activation of EP 1 , EP 3 , FP and TP receptors by uterotonins either reduces intracellular cAMP or mobilises calcium to facilitate
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strong affinity to porcine CRSP-1 and mediates its signal into cells by activating adenylyl cyclase. Porcine CT-R was transiently expressed in COS-7 cells, and then those cells were stimulated with ovine/caprine CRSP-1 or caprine CRSP-2 and compared with
Laboratory of Animal Physiology, Department of Animal Biology, Institute of Biomedical Technologies, University of La Laguna, La Laguna, Spain
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Laboratory of Animal Physiology, Department of Animal Biology, Institute of Biomedical Technologies, University of La Laguna, La Laguna, Spain
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Laboratory of Animal Physiology, Department of Animal Biology, Institute of Biomedical Technologies, University of La Laguna, La Laguna, Spain
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Laboratory of Animal Physiology, Department of Animal Biology, Institute of Biomedical Technologies, University of La Laguna, La Laguna, Spain
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Laboratory of Animal Physiology, Department of Animal Biology, Institute of Biomedical Technologies, University of La Laguna, La Laguna, Spain
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-epinephrine (NE), and that this effect was apparently exerted at a level upstream adenylyl cyclase (AC; Martinez-Morales et al. 2001 ). In the present work, we have investigated whether this modulatory effect can be exerted through estrogen interactions with
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
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Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
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Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
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Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
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receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase. Endocrinology 141 1301 –1309. Wheeler MB , Lu M, Dillon JS, Leng X-H, Chen C & Boyd AE 1993 Functional
