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Sonu Khanka Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Charul Somani Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India

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Kriti Sharma Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Shivani Sharma Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Akhilesh Kumar Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India

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Naibedya Chattopadhyay Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Sanjeev K Kanojiya Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India

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Dinesh Kumar Yadav Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India

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Divya Singh Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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histomorphometry (new bone formation rate assessment) For assessment of new bone formation rate in vivo , previously published protocol was followed ( Rai et al. 2021 ). Briefly two intraperitoneal injection of Calcein dye (20 mg/kg body weight) was given to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0351
Volume/Issue:
Volume 261: Issue 2
Restricted access
M Alexandra Sorocéanu
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Dengshun Miao
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Xiu-Ying Bai
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Hanyi Su
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David Goltzman
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Andrew C Karaplis
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administration, an increase in the number of bone marrow adipocytes at the expense of the number and differentiation potential of osteoblast progenitors could lead to suppression of bone formation and osteoporosis ( Schwartz et al. 2002 , Rzonca et al. 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05723
Volume/Issue:
Volume 183: Issue 1
Free access
Lara H Sattgast Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Adam J Branscum Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Natali Newman Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Steven W Gonzales Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Mary Lauren Benton Department of Computer Science, Baylor University, Waco, Texas, USA

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Erich J Baker Department of Computer Science, Baylor University, Waco, Texas, USA

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Kathleen A Grant Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Russell T Turner Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Urszula T Iwaniec Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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osteocalcin (a marker of bone formation) did not change ( Labib et al. 1989 , Sripanyakorn et al. 2009 ). In addition, serum CTX and osteocalcin levels increased in postmenopausal women following 2 weeks of abstinence from ethanol, and these levels

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0075
Volume/Issue:
Volume 255: Issue 3
Restricted access
Alok Tripathi Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

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Pallavi Awasthi Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India
Division of Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India

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Kundan Singh Rawat Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India
Division of Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India

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Atma P Dwivedi Division of Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India

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Krishna Bhan Singh Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

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Kriti Sharma Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

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Ravi Prakash Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India

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Divya Singh Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

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Atul Goel Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India
Division of Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India

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process leads to increased bone resorption with a concomitant decrease in bone formation, thus leading to deterioration of bone architecture and increased chances of fractures. The current medications used to control shift in bone remodeling are anti

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0439
Volume/Issue:
Volume 254: Issue 1
Restricted access
Jessica L Pierce Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Anuj K Sharma Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Natalia del Mazo Arbona Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zuleika Rodríguez-Santos Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Paul J Bernard Pediatric Endocrine Specialists of Georgia, Duluth, Georgia, USA

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Wendy B Bollag Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Physiology, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Charlie Norwood VA Medical Center, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Mark W Hamrick Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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Dana L Begun Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Xing-Ming Shi Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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regulatory elements ( Hua et al. 2016 a , b ). While physiological levels of endogenous glucocorticoids are necessary for osteoblastogenesis and bone formation ( Zhou et al. 2013 ), an excess of circulating glucocorticoids can compromise bone mass by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0230
Volume/Issue:
Volume 243: Issue 1
Free access
Isabel R Orriss Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

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Dilek Guneri Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

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Mark O R Hajjawi Department of Cell & Developmental Biology, University College London, London, UK

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Kristy Shaw Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

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Jessal J Patel Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

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Timothy R Arnett Department of Cell & Developmental Biology, University College London, London, UK

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−/− ) demonstrated large increases in trabecular and cortical bone parameters in the long bones ( Orriss et al. 2007 , Orriss et al. 2011 a ). Furthermore, P2Y 2 overexpression leads to decreased bone formation ( Syberg et al. 2012 a ), and polymorphisms in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0042
Volume/Issue:
Volume 233: Issue 3
Free access
David E Maridas Maine Medical Center Research Institute, Scarborough, Maine, USA

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Victoria E DeMambro Maine Medical Center Research Institute, Scarborough, Maine, USA

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Phuong T Le Maine Medical Center Research Institute, Scarborough, Maine, USA

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Kenichi Nagano Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Roland Baron Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Subburaman Mohan VA Loma Linda Healthcare System, Loma Linda, California, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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conflicting results. Indeed, systemic injections of IGFBP-4 in mice induced bone formation, whereas local injections inhibited IGF actions on the bone ( Miyakoshi et al . 2001 ). Furthermore, overexpression of IGFBP-4 in bone resulted in a decrease in bone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0673
Volume/Issue:
Volume 233: Issue 1
Open access
Alessandra Bitto
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Francesca Polito
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Bruce Burnett Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Robert Levy Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Vincenzo Di Stefano
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Mary Ann Armbruster Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Herbert Marini Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Letteria Minutoli
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Domenica Altavilla
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Francesco Squadrito
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fast rate becoming significant within the first 6 months ( van Staa et al . 2002 ). GC therapy is responsible for bone loss via different mechanisms that can be summarized as a decrease in bone formation and an increase in bone resorption. More

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0552
Volume/Issue:
Volume 201: Issue 3
Free access
Claes Ohlsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Petra Henning Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin H Nilsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Jianyao Wu Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin L Gustafsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Klara Sjögren Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Anna Törnqvist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Antti Koskela Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Fu-Ping Zhang Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Marie K Lagerquist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Matti Poutanen Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Juha Tuukkanen Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Ulf H Lerner Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Sofia Movérare-Skrtic Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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osteoclast progenitor cells and by enhancing Opg expression in osteoblasts ( Moverare-Skrtic et al . 2014 ). In addition, it has been described that WNT16 may also regulate periosteal bone formation rate ( Wergedal et al . 2015 ). Although very

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0020
Volume/Issue:
Volume 237: Issue 2
Open access
Bradley S Miller Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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James T Bronk Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Takayuki Nishiyama Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Hiroshi Yamagiwa Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Alok Srivastava Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Mark E Bolander Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Cheryl A Conover Endocrine Research Unit,
Division of Orthopedic Surgery, Mayo Clinic, 200 First, Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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process of new bone formation at the epiphyseal growth plate ( Ferguson et al. 1999 , Gerstenfeld et al. 2003 ), and the IGFs were discovered based on their essential role in this new bone formation required for linear growth ( Le Roith et al. 2001

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0011
Volume/Issue:
Volume 192: Issue 3
Free access