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Georgina G J Hazell
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Song T Yao
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James A Roper
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Eric R Prossnitz LINE, University of New Mexico, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Anne-Marie O'Carroll
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Stephen J Lolait
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614 – 623 . Burbach JPH Luckman SM Murphy D Gainer H 2001 Gene regulation in the magnocellular hypothalamo-neurohypophysial system . Physiological Reviews 81 1198 – 1266 . Carmeci C Thompson DA Ring HZ Francke U Weigel RJ

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0066
Volume/Issue:
Volume 202: Issue 2
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Rene F Chun Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA

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John S Adams Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA

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Martin Hewison Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA

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that was able to compete with the VDR-retinoid X receptor (RXR) complex for binding to VDRE during 1,25(OH) 2 D-VDR-directed gene regulation ( Arbelle et al . 1996 ). This factor was subsequently referred to as the VDRE-BP. Similar observations have

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0170
Volume/Issue:
Volume 198: Issue 2
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Noriko Sakai
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Hiromi Terami
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Shinobu Suzuki
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Megumi Haga
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Ken Nomoto
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Nobuko Tsuchida
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Ken-ichirou Morohashi Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Naoaki Saito Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Maki Asada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Megumi Hashimoto Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Daisuke Harada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Hiroshi Asahara Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Tetsuya Ishikawa
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Fumiki Shimada
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Kazuhiro Sakurada
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the steroid-producing cells. Further studies would be expected for the expression and function of all identified target genes on NF5A1 gene regulations across various endocrine tissues. Expression of identified genes might be restricted to stem

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Research Article
DOI:
https://doi.org/10.1677/JOE-08-0027
Volume/Issue:
Volume 198: Issue 3
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Cristina Aresté
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M Jesús Melià
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Joan Isern
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José Luis Tovar
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Anna Meseguer
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growth, homeostasis, differentiation and development. The molecular nature of tissue-specific gene regulation by androgens has not been well defined, partly as a result of the variable expression and incomplete regulation of currently available gene

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Research Article
DOI:
https://doi.org/10.1677/joe.1.05649
Volume/Issue:
Volume 183: Issue 1
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Jorge Diaz Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Evelyn Aranda Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Soledad Henriquez Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Marisol Quezada Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Estefanía Espinoza Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Maria Loreto Bravo Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Bárbara Oliva Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Soledad Lange Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Manuel Villalon Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Marius Jones Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Jan J Brosens Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Sumie Kato Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Mauricio A Cuello Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Todd P Knutson Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Carol A Lange Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Lisette Leyton Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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Gareth I Owen Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and

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the selective nature of phospho-Ser294 PR on PR target gene regulation. Although this is not the first observation that progesterone can regulate PAR1 , this is, to our knowledge, the first to demonstrate regulation in breast cancer or mammary gland

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0310
Volume/Issue:
Volume 214: Issue 2
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Jay H Lo Department of Molecular and Cell Biology, University of Connecticut, 91 N. Eagleville Road, U-3125, Storrs, Connecticut 06269, USA

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Pinwen Peter Chiou Department of Molecular and Cell Biology, University of Connecticut, 91 N. Eagleville Road, U-3125, Storrs, Connecticut 06269, USA

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C M Lin Department of Molecular and Cell Biology, University of Connecticut, 91 N. Eagleville Road, U-3125, Storrs, Connecticut 06269, USA

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Thomas T Chen Department of Molecular and Cell Biology, University of Connecticut, 91 N. Eagleville Road, U-3125, Storrs, Connecticut 06269, USA

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factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacological Reviews 56

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Research Article
DOI:
https://doi.org/10.1677/JOE-07-0085
Volume/Issue:
Volume 194: Issue 2
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Pia Kiilerich Institute of Biology and
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Campusvej 55, DK-5230 Odense M, Denmark

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Karsten Kristiansen Institute of Biology and
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Campusvej 55, DK-5230 Odense M, Denmark

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Steffen S Madsen Institute of Biology and
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Campusvej 55, DK-5230 Odense M, Denmark

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requirement to investigate the signaling pathways of GR and MR in fish. The knowledge of osmoregulatory gene regulation by cortisol in fish gill is scarce and little is known about exact cortisol signaling mechanisms through GR and MR. This is the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0185
Volume/Issue:
Volume 194: Issue 2
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Nariaki Fujimoto Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Radiation Responses, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Xenobiotic Metabolism and Molecular Toxicology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan

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Yukimi Akimoto Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Radiation Responses, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Xenobiotic Metabolism and Molecular Toxicology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan

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Tomoharu Suzuki Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Radiation Responses, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Xenobiotic Metabolism and Molecular Toxicology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan

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Shigeyuki Kitamura Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Radiation Responses, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Xenobiotic Metabolism and Molecular Toxicology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan

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Shigeru Ohta Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Radiation Responses, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Department of Xenobiotic Metabolism and Molecular Toxicology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan

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has delineated the main mouse prostatic secretion pattern for the first time. The data will be useful for studying androgen-dependent gene regulation in the prostate, and may also provide markers for studying functional differentiation of prostate

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06733
Volume/Issue:
Volume 190: Issue 3
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A M Solomon Department of Endocrinology, Royal Free Hospital and Medical School, Pond Street, London NW3 2PF, UK

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P M G Bouloux Department of Endocrinology, Royal Free Hospital and Medical School, Pond Street, London NW3 2PF, UK

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measure glucocorticoid-dependent transactivation and transrepression of gene regulation. Journal of Steroid Biochemistry and Molecular Biology 88 191 –201. Carel JC 2005 Growth hormone in Turner syndrome: twenty years

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06837
Volume/Issue:
Volume 191: Issue 2
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Craig L Doig School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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Jamila Bashir School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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Agnieszka E Zielinska School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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Mark S Cooper School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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Paul M Stewart School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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Gareth G Lavery School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK

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muscle, adipocytes from p65 overexpression transgenic mice had elevated 11β-HSD1 at the mRNA and protein level, but show no evidence for direct gene regulation ( Lee et al . 2013 ). In this context, NF-κB was acting as a positive regulator in a model of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0494
Volume/Issue:
Volume 220: Issue 3
Open access