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-019-1168-5 ) Wicksteed B Brissova M Yan W Opland DM Plank JL Reinert RB Dickson LM Tamarina NA Philipson LH Shostak A , 2010 Conditional gene targeting in mouse pancreatic β-cells: analysis of ectopic cre transgene expression in the brain

uncovered, some of which may be indirectly regulated by altered levels of available FSH or represent bona fide novel FSH-regulated genes. Targets not previously identified in the testis include aminolevulinic acid synthase 2 and melanoma inhibitory activity

action in bone, such approaches cannot identify the in vivo cell targets of T 3 action and the application of cell-specific gene-targeting strategies is now required. Skeletal development During endochondral ossification, mesenchyme

protein-coding genes in C57BL/6 mouse ES cells by 2021 ( Collins et al . 2007 ). The IKMC-targeted mutagenesis techniques involve use of bacterial artificial chromosome (BAC)-based ‘Knockout-First’ conditional ready gene targeting vectors that use

Biophysica Acta 1346 231 –236. Walsh V , Somody L, Farrell A, Zhang B, Brown J, Pritchard C, Vincent M & Samani NJ 2003 Analysis of the Role of the SA gene in blood pressure regulation by gene targeting. Hypertension 41

data have important implications for physiological vs pathological regulation of circadian gene targets where fluctuations between ligand availability, receptor levels and thus MR and GR homodimers or MR/GR heterodimers contribute to the net regulatory

identified that are highly conserved between species (e.g., Supplementary Table 1, see section on supplementary data given at the end of this article). MicroRNAs in gamete maturation Taking advantage of conditional gene targeting approaches in mice

Shostak A , et al . 2010 Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain . Diabetes 59 3090 – 3098 . ( https://doi.org/10.2337/db10-0624 ) 10.2337/db10-0624 20802254 Wittenberg

Mitchell R Huss R Moll U Muller W Bucala R 2003 The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting . PNAS 100 9354 – 9359 . ( https://doi.org/10.1073/pnas.1533295100 ) 10.1073/pnas.1533295100 12878730

S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED , 2013 Lessons on conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . ( https://doi.org/10.2337/db12-1089 ) 10.2337/db12-1089 23321074 Mayoral