Search Results

You are looking at 41 - 50 of 4,484 items for :

  • Refine by access: All content x
Clear All
Takumi Takeuchi Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Takumi Takeuchi in
Google Scholar
PubMed
Close
,
Motofumi Suzuki Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Motofumi Suzuki in
Google Scholar
PubMed
Close
,
Jimpei Kumagai Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Jimpei Kumagai in
Google Scholar
PubMed
Close
,
Toshiyuki Kamijo Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Toshiyuki Kamijo in
Google Scholar
PubMed
Close
,
Masato Sakai Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Masato Sakai in
Google Scholar
PubMed
Close
, and
Tadaichi Kitamura Department of Urology and Andrology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Search for other papers by Tadaichi Kitamura in
Google Scholar
PubMed
Close

whether dermatopontin enhances or suppresses the proliferation of cells and the accumulation of the extracellular matrices. Dermatopontin enhanced the growth-inhibitory activity of transforming growth factor (TGF)-β on mink lung epithelial cells through

Free access
Christopher A Price Faculty of Veterinary Medicine, Centre de recherche en reproduction animale, University of Montreal, 3200 rue Sicotte, St‐Hyacinthe, Quebec, Canada J2S 7C6

Search for other papers by Christopher A Price in
Google Scholar
PubMed
Close

drivers of many stages of follicle development; however, it is becoming increasingly evident that several families of growth factors also play important roles within the follicle, including the insulin-like growth factor and transforming growth factor beta

Free access
A L Pierce
Search for other papers by A L Pierce in
Google Scholar
PubMed
Close
,
H Fukada
Search for other papers by H Fukada in
Google Scholar
PubMed
Close
, and
W W Dickhoff
Search for other papers by W W Dickhoff in
Google Scholar
PubMed
Close

Introduction The growth hormone (GH)/insulin-like growth factor (IGF) axis is the primary endocrine system that regulates body growth in vertebrates (reviewed in Rosenfeld & Roberts 1999 ). The principal hormones in the GH/IGF axis

Free access
Lorena González
Search for other papers by Lorena González in
Google Scholar
PubMed
Close
,
Ma. Eugenia Díaz
Search for other papers by Ma. Eugenia Díaz in
Google Scholar
PubMed
Close
,
Johanna G Miquet
Search for other papers by Johanna G Miquet in
Google Scholar
PubMed
Close
,
Ana I Sotelo
Search for other papers by Ana I Sotelo in
Google Scholar
PubMed
Close
,
Diego Fernández Departamento de Química Biológica, Cátedra de Bioquímica Humana, Geriatrics Research, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina

Search for other papers by Diego Fernández in
Google Scholar
PubMed
Close
,
Fernando P Dominici
Search for other papers by Fernando P Dominici in
Google Scholar
PubMed
Close
,
Andrzej Bartke Departamento de Química Biológica, Cátedra de Bioquímica Humana, Geriatrics Research, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina

Search for other papers by Andrzej Bartke in
Google Scholar
PubMed
Close
, and
Daniel Turyn
Search for other papers by Daniel Turyn in
Google Scholar
PubMed
Close

Introduction The relevance of growth factors to the pathogenesis of human cancer has long been established. Different mechanisms may contribute to amplify the signal driven by growth factors: the overexpression of growth factors or the

Free access
F A Hills
Search for other papers by F A Hills in
Google Scholar
PubMed
Close
,
M G Elder
Search for other papers by M G Elder in
Google Scholar
PubMed
Close
,
T Chard
Search for other papers by T Chard in
Google Scholar
PubMed
Close
, and
M H F Sullivan
Search for other papers by M H F Sullivan in
Google Scholar
PubMed
Close

Introduction Proper development of the human placenta is essential if normal pregnancy is to be maintained. This includes growth of the placenta, differentiation of the trophoblast and vascular systems, invasion of extravillous

Free access
Pi-Jung Hsiao
Search for other papers by Pi-Jung Hsiao in
Google Scholar
PubMed
Close
,
Ming-Ying Lu
Search for other papers by Ming-Ying Lu in
Google Scholar
PubMed
Close
,
Feng-Yu Chiang
Search for other papers by Feng-Yu Chiang in
Google Scholar
PubMed
Close
,
Shyi-Jang Shin
Search for other papers by Shyi-Jang Shin in
Google Scholar
PubMed
Close
,
Yu-Da Tai
Search for other papers by Yu-Da Tai in
Google Scholar
PubMed
Close
, and
Suh-Hang Hank Juo
Search for other papers by Suh-Hang Hank Juo in
Google Scholar
PubMed
Close

lymphatic system ( Turner et al. 2003 ). Angiogenesis is a process of new blood vessel development from preexisting vasculature. The vascular endothelial growth factor (VEGF) is one of the most potent endothelial cell mitogens and plays a crucial

Free access
Rakefet Pando Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Rakefet Pando in
Google Scholar
PubMed
Close
,
Majdi Masarwi Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Majdi Masarwi in
Google Scholar
PubMed
Close
,
Biana Shtaif Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Biana Shtaif in
Google Scholar
PubMed
Close
,
Anna Idelevich Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Anna Idelevich in
Google Scholar
PubMed
Close
,
Efrat Monsonego-Ornan Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Efrat Monsonego-Ornan in
Google Scholar
PubMed
Close
,
Ron Shahar Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Ron Shahar in
Google Scholar
PubMed
Close
,
Moshe Phillip Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Moshe Phillip in
Google Scholar
PubMed
Close
, and
Galia Gat-Yablonski Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

Search for other papers by Galia Gat-Yablonski in
Google Scholar
PubMed
Close

Introduction Although there are numerous genetic and environmental factors that may affect growth, malnutrition, marked by various nutrient deficiencies, is considered to be a leading cause of low weight and short stature. In the developing

Free access
Ola Nilsson Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Ola Nilsson in
Google Scholar
PubMed
Close
,
Elizabeth A Parker Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Elizabeth A Parker in
Google Scholar
PubMed
Close
,
Anita Hegde Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Anita Hegde in
Google Scholar
PubMed
Close
,
Michael Chau Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Michael Chau in
Google Scholar
PubMed
Close
,
Kevin M Barnes Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Kevin M Barnes in
Google Scholar
PubMed
Close
, and
Jeffrey Baron Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Search for other papers by Jeffrey Baron in
Google Scholar
PubMed
Close

Introduction In mammals, longitudinal bone growth occurs primarily at the growth plate. The growth plate contains chondrocytes spatially organized in three distinct zones according to defined stages of differentiation. The resting

Free access
L. L. ANDERSON
Search for other papers by L. L. ANDERSON in
Google Scholar
PubMed
Close
,
J. FEDER
Search for other papers by J. FEDER in
Google Scholar
PubMed
Close
, and
C. R. BOHNKER
Search for other papers by C. R. BOHNKER in
Google Scholar
PubMed
Close

Department of Animal Science, Iowa State University, Ames, Iowa 50011, U.S.A.

(Received 29 August 1975)

A previous investigation on growth in the immature pig indicated that hypophysectomy leads to a markedly reduced growth rate, but not complete cessation of growth (Ford & Anderson, 1967). Results are presented on the effect of exogenous growth hormone (GH) on growth and development in immature hypophysectomized pigs.

Immature male Yorkshire pigs were hypophysectomized by a supraorbital approach (du Mesnil du Buisson, Léglise & Chodkiewicz, 1964). The animals were anaesthetized with sodium thiopentone (0·3–0·8 g; Abbott Laboratories) and surgical anaesthesia was maintained with oxygen (200–500 ml/min) and halothane (1–4%; Ayerst Laboratories). Sham-operations included all surgical procedures except removal of the hypophysis. After surgery the pigs were isolated in individual pens in a postoperative room maintained at 24–25 °C.

Porcine growth hormone (PGH) or rat growth hormone (RGH) was injected intramuscularly at 1·0 mg/day during a

Restricted access
A. L. Ogilvy-Stuart
Search for other papers by A. L. Ogilvy-Stuart in
Google Scholar
PubMed
Close
and
S. M. Shalet
Search for other papers by S. M. Shalet in
Google Scholar
PubMed
Close

In a child, puberty encompasses a series of events which include the completion of growth and the maturing of the reproductive system. One of the common hormonal links between these two processes is growth hormone (GH) and, although it has been known for some time that the reproductive axis influences GH secretion and growth, increasing interest is developing in the alternative possibility of GH modifying reproductive processes.

In the normal child, there is an increase in GH secretion from mid-childhood with a shift in periodicity and an increase in pulse amplitude (Hindmarsh, Mathews & Brook, 1988). The two- to threefold rise in GH secretion during puberty is a product of the increase in pulse amplitude over the prepubertal value (Martha, Rogol, Veldhuis et al. 1989; Delemarre-van de Waal, Wennink & Odink, 1991). GH pulse amplitude is increased during early puberty in girls and at a later stage in boys, corresponding

Restricted access