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Sonu Khanka Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Charul Somani Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India

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Kriti Sharma Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Shivani Sharma Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Akhilesh Kumar Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India

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Naibedya Chattopadhyay Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Sanjeev K Kanojiya Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India

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Dinesh Kumar Yadav Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India

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Divya Singh Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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for skeletal histomorphometry and serum biochemical analysis. Samples were fixed in 10% neutral formaldehyde for subsequent histological analyses ( Singh et al. 2022 ). Assessment of body composition Before autopsy mice were scanned using

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0351
Volume/Issue:
Volume 261: Issue 2
Restricted access
Kotaro Azuma Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Stephanie C Casey Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Masako Ito Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Tomohiko Urano Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Kuniko Horie Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Yasuyoshi Ouchi Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Séverine Kirchner Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Bruce Blumberg Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Satoshi Inoue Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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indicator of plate-like trabecular architecture (score 0) versus rod-like trabecular architecture (score 3). Bone histomorphometry Mice were injected with 20 mg/kg tetracycline hydrochloride s.c. 5 days before killing. Then, they were injected with 20 mg

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0208
Volume/Issue:
Volume 207: Issue 3
Free access
Jonathan H Gooi
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Ling Yeong Chia
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Nicole C Walsh
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Morten A Karsdal St Vincent's Institute, Nordic Bioscience Inc., and Department of Medicine, at St Vincent's Hospital, The University of Melbourne, 9 Princes Street, Fitzroy, Victoria 3065, Australia

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Julian M W Quinn
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T John Martin
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Natalie A Sims
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assayed by mass spectrometry ( Han et al . 2007 ). Serum PTH in rats was measured by a rat Intact PTH ELISA Kit (Immunotopics, San Clemente, CA, USA), which does not detect the human PTH(1–34) peptide used for injections. Histomorphometry and pQCT Tibiae

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0524
Volume/Issue:
Volume 221: Issue 2
Free access
Miskal Sbaihi Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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Karine Rousseau Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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Sylvie Baloche Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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François Meunier Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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Martine Fouchereau-Peron Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France
Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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Sylvie Dufour Muséum National d'Histoire Naturelle, Marine Station of Concarneau, DMPA USM 0401, UMR 7208 CNRS BOREA ‘Biologie des Organismes et Ecosystèmes Aquatiques’, 7 rue Cuvier, CP 32, 75231 Paris Cedex 05, France

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modulates glucocorticoid-induced alteration in serum bone gla protein and bone histomorphometry . Endocrinology 120 531 – 536 . Jowsey J Kelly PJ Riggs BL Bianco AJ Scholz DA Gershon-Cohen J 1965 Quantitative microradiographic studies of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0492
Volume/Issue:
Volume 201: Issue 2
Free access
James K Yeh Department of Medicine, Winthrop University Hospital, Mineola, New York 11501, USA
The Health Sciences Center, State University of New York, Stony Brook, New York 11794, USA

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Jodi F Evans Department of Medicine, Winthrop University Hospital, Mineola, New York 11501, USA
The Health Sciences Center, State University of New York, Stony Brook, New York 11794, USA

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Qing-Tian Niu Department of Medicine, Winthrop University Hospital, Mineola, New York 11501, USA
The Health Sciences Center, State University of New York, Stony Brook, New York 11794, USA

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John F Aloia Department of Medicine, Winthrop University Hospital, Mineola, New York 11501, USA
The Health Sciences Center, State University of New York, Stony Brook, New York 11794, USA

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, MO, USA). Histomorphometry After being thoroughly cleaned of soft tissues, distal portions of each right femur were cut using an Isomet saw (Buehler, Lake Bluff, IL, USA) and stained at 4 °C using Villanueva

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06729
Volume/Issue:
Volume 191: Issue 3
Free access
Claire L Wood Division of Developmental Biology, Roslin Institute, University of Edinburgh, Edinburgh, UK

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Ondrej Soucek Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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Sze C Wong Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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Farasat Zaman Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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Colin Farquharson Division of Developmental Biology, Roslin Institute, University of Edinburgh, Edinburgh, UK

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Lars Savendahl Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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S Faisal Ahmed Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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describe changes in bone health after GC exposure: Bone histomorphometry Traditional methods to assess changes in bone structure include the evaluation of histological sections of mineralized bone. In basic osteoporosis research, lumbar vertebral

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0361
Volume/Issue:
Volume 236: Issue 1
Free access
Filip Callewaert Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Mieke Sinnesael Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Evelien Gielen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Steven Boonen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Dirk Vanderschueren Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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development of the skeletal sexual dimorphism ( Callewaert et al . 2010 b ). In fact, periosteal and endosteal bone formation rates, as determined by dynamic histomorphometry, are higher and lower respectively in male versus female mice. Obviously, similar

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0209
Volume/Issue:
Volume 207: Issue 2
Free access
Jessica L Pierce Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Anuj K Sharma Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Natalia del Mazo Arbona Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zuleika Rodríguez-Santos Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Paul J Bernard Pediatric Endocrine Specialists of Georgia, Duluth, Georgia, USA

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Wendy B Bollag Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Physiology, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Charlie Norwood VA Medical Center, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Mark W Hamrick Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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Dana L Begun Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Xing-Ming Shi Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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Nr3c1, the murine glucocorticoid receptor. Micro-computed tomography, histology, histomorphometry and immunohistochemistry Femora and tibiae were harvested at killing and fixed in 10% neutral buffered formalin for 24 hours followed by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0230
Volume/Issue:
Volume 243: Issue 1
Restricted access
K Rousseau Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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Z Atcha Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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J Denton Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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F R A Cagampang Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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A R Ennos Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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A J Freemont Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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A S I Loudon Faculties of Life Sciences and
Medicine, Stopford Building, University of Manchester, Manchester M13 9PT, UK

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oblong box attached to its neighbouring vertebrae at each end. The ends are actively growing and therefore possess growth plates. As growth plates are not examined in bone histomorphometry, our measurements excluded both the growth plate and the cortical

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06207
Volume/Issue:
Volume 186: Issue 3
Free access
Nicholaos I Papachristou Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras Medical School, Patras, Greece

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Harry C Blair Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pittsburgh VA Medical Center, Pittsburgh, Pennsylvania, USA

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Kyriakos E Kypreos Department of Pharmacology, University of Patras Medical School, Patras, Greece

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Dionysios J Papachristou Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras Medical School, Patras, Greece
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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plasma and HDL cholesterol. Dynamic and static (μCT-based) histomorphometry uncovered that Scarb1 deficiency was followed by increased bone volume and elevated osteoblast number and function, particularly in the trabecular bone of 2-month-old female

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0657
Volume/Issue:
Volume 233: Issue 2
Free access