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Iulia Potorac Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Université de Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Adolfo Rivero-Müller Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
Faculty of Natural Sciences and Technology, Åbo Akademi University, Turku, Finland
Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland

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Ashutosh Trehan Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland

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Michał Kiełbus Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland

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Krzysztof Jozwiak Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, Lublin, Poland

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Francois Pralong Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, CHU Vaudois, Lausanne, Switzerland

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Aicha Hafidi Department of Diabetology and Metabolic Diseases, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco

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Albert Thiry Department of Pathology, Centre Hospitalier Universitaire de Liège, Université de Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-Jacques Ménagé Endocrinology Practice, Fontainebleau, France

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Ilpo Huhtaniemi Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Hammersmith Campus, Imperial College London, London, UK

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Université de Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Université de Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Introduction Luteinizing hormone (LH) belongs to the heterodimeric glycoprotein hormone family whose other members are human chorionic gonadotropin (hCG), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) ( Cahoreau et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0384
Volume/Issue:
Volume 231: Issue 3
Free access

Local impact of thyroid hormone inactivation

Deiodinases: the balance of thyroid hormone

Monica Dentice Department of Molecular and Clinical Endocrinology and Oncology, University of Naples ‘Federico II’, Via S. Pansini 5, 80131 Naples, Italy

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Domenico Salvatore Department of Molecular and Clinical Endocrinology and Oncology, University of Naples ‘Federico II’, Via S. Pansini 5, 80131 Naples, Italy

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Introduction Thyroid hormone action and deiodinases Thyroid hormones (THs) are iodinated compounds known to influence gene expression in virtually every vertebrate cell; they exert this function through ligand-dependent transcription factors, namely

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0002
Volume/Issue:
Volume 209: Issue 3
Free access
Natasha N Chattergoon Center for Developmental Health, Oregon Health and Science University, Portland, Oregon, USA
Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA

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Introduction Over the past 25 years, the many roles that thyroid hormone (TH) plays in regulating fetal development have come to light. Because maternal plasma thyroid hormone levels influence fetal levels, abnormal maternal thyroid hormone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0704
Volume/Issue:
Volume 242: Issue 1
Free access
Stephen G Hillier Medical Research Council Centre for Reproductive Health, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Richard Lathe Division of Infection and Pathway Medicine, University of Edinburgh Medical School, Edinburgh, UK

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, cardenolides (poisons), saponins (vegetable soaps), and withanolides (plant defense substances). Present-day insects do not biosynthesize cholesterol de novo but metabolize dietary molecules such as cholesterol into ecdysteroids (moulting hormones). Nematodes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0084
Volume/Issue:
Volume 242: Issue 2
Free access
J M Hanson Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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H S Kooistra Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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J A Mol Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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E Teske Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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B P Meij Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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’s disease ( Lamberts 2002 , Reimondo et al. 2003 ), PDH in dogs is characterized by adrenocorticotropic hormone (ACTH)-induced hypercortisolism and reduced sensitivity to glucocorticoid feedback inhibition ( Rijnberk et al. 1988 a , Bosje et al. 2002

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06782
Volume/Issue:
Volume 190: Issue 3
Free access
Zhengxiang Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Lili Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Chengjian Wang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Shanli Zhu School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Xinzhou Qi School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Yang Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Yanjun Zhang School of Information Technology and Electrical Engineering, University of Queensland, St Lucia, Brisbane, Australia

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Michael A Cowley Department of Physiology, Monash University, Melbourne, Australia

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Johannes D Veldhuis Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota, USA

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Chen Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Introduction Hormonal disturbance, in either secretion amount or function, often occurs in parallel with impairment of glucose/lipid/protein metabolism in obesity. Two pivotal hormones, insulin and growth hormone (GH), which synergistically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0385
Volume/Issue:
Volume 245: Issue 1
Restricted access
Nancy H Nabilsi
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Russell R Broaddus Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Adrienne S McCampbell Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Karen H Lu Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Henry T Lynch Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Lee-may Chen Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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David S Loose
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signaling. Both positive and negative feedback loops within the hypothalamus and pituitary control steroid hormone production in the ovaries. Increased estrogen (E 2 ) drives the endometrium into the proliferative phase of the cycle. As the cycle progresses

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0128
Volume/Issue:
Volume 207: Issue 2
Free access
Noelia Martínez-Sánchez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José M Moreno-Navarrete CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Cristina Contreras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Eva Rial-Pensado Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José-Manuel Fernández-Real CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Miguel López Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Introduction Thyroid hormones (THs; 3,3′,5,5′ tetraiodothyroxyne or T 4 and 3,3′,5-triiodothyronine or T 3 ) exert important biological actions, not only modulating the development and growth but also regulating metabolism and energy balance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0425
Volume/Issue:
Volume 232: Issue 2
Open access
Ángel Enrique Céspedes Rubio Departamento de Sanidad Animal, Grupo de Investigación en Enfermedades Neurodegenerativas, Universidad del Tolima, Ibagué, Colombia

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Maria José Pérez-Alvarez Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Departamento de Neuropatología Molecular CSIC-UAM, Madrid, Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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Catalina Lapuente Chala Grupo de Investigación en Enfermedades Neurodegenerativas, Investigador Asociado Universidad del Tolima, Ibagué, Colombia

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Francisco Wandosell Centro de Biología Molecular ‘Severo Ochoa’, Departamento de Neuropatología Molecular CSIC-UAM, Madrid, Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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Introduction Estrogens and progestogens are the main female sexual hormones, both mainly synthesized and secreted to the blood by the ovaries (under pituitary control) and placenta and produced by the adrenal glands in both males and females

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0129
Volume/Issue:
Volume 237: Issue 2
Free access
Marta Toral Departamento de Farmacología, Facultad de Farmacia, Granada, Spain

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Rosario Jimenez Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Sebastián Montoro-Molina Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Miguel Romero Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Rosemary Wangensteen Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Juan Duarte Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Félix Vargas Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain
Departamento de Fisiología, Facultad de Medicina, Granada, Spain

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A, CAT-2B, CAT-3 and CAT-4), is the major cationic amino acid transport system and accounts for ~60% of the transport of the intracellular supply of L-arginine for NOS ( Verrey et al. 2004 ). Thyroid hormone excess is associated with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0229
Volume/Issue:
Volume 239: Issue 1
Free access