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Bo He Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China

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Yinxian Wen Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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Shuwei Hu Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Guihua Wang Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Wen Hu Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Jacques Magdalou UMR 7561 CNRS-Université de Lorraine, Faculté de Médicine, Vandoeuvre-lès-Nancy, Nancy, France

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Liaobin Chen Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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Hui Wang Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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to metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) ( Xu et al. 2012 a , Wang et al. 2014 ). Meanwhile, we recently reported that PCE induces hyperinsulinemia, insulin resistance and high susceptibility to metabolic syndrome in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0066
Volume/Issue:
Volume 242: Issue 3
Free access
Hongying An Divisions of Metabolism and Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Ling He Divisions of Metabolism and Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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patients ( Magnusson et al. 1992 , Saltiel & Kahn 2001 , Wajngot et al. 2001 ). It is now clear that metformin improves hyperglycemia mainly through the suppression of gluconeogenesis in the liver. In a human study, treatment of patients with T2D with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0447
Volume/Issue:
Volume 228: Issue 3
Free access
Daniela F Bertelli Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Andressa Coope Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Andrea M Caricilli Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Patricia O Prada Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Mario J Saad Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Licio A Velloso Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing
Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Eliana P Araujo Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing
Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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extracts, obtained from thymus (Ty), skeletal muscle (SM), liver (Li), white adipose tissue (WAT), spleen (Sp), cardiac muscle (He), lung (Lu), and kidney (Ki), from 8-week old male Wistar rats were separated by SDS–PAGE, transferred to nitrocellulose

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0562
Volume/Issue:
Volume 217: Issue 2
Free access
Asghar Ali Colorado State University, Animal Reproduction and Biotechnology Lab, Fort Collins, Colorado, USA

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Callie M Swanepoel Colorado State University, Animal Reproduction and Biotechnology Lab, Fort Collins, Colorado, USA

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Quinton A Winger Colorado State University, Animal Reproduction and Biotechnology Lab, Fort Collins, Colorado, USA

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Paul J Rozance Perinatal Research Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Russell V Anthony Colorado State University, Animal Reproduction and Biotechnology Lab, Fort Collins, Colorado, USA

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, trophoblast giant cells in mice and chorionic binucleate cells in sheep ( Gootwine 2004 , Sibiak et al. 2020 ). CSH binding has been identified in several maternal and fetal sheep tissues, including skeletal muscle, pancreas and liver ( Chan et al. 1978

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0375
Volume/Issue:
Volume 247: Issue 3
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Giselle Adriana Abruzzese Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Maria Florencia Heber Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Silvana Rocio Ferreira Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Leandro Martin Velez Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Roxana Reynoso Laboratorio de Endocrinología, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Omar Pedro Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Alicia Beatriz Motta Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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tissues is unknown. The liver is involved in lipid synthesis, transportation and storage, as well as in glucose and insulin metabolism ( Paschos & Paletas 2009 ), all key factors in PCOS pathogenesis ( den Boer et al . 2004 , Paschos & Paletas 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0471
Volume/Issue:
Volume 230: Issue 1
Free access
Chunyan Zhao Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden

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Karin Dahlman-Wright Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden

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Liver X receptor The liver X receptors (LXRs), LXRα (NR1H3) and LXRβ (NR1H2), belong to the nuclear receptor superfamily of ligand-activated transcription factors ( Janowski et al . 1996 ). LXRα was initially isolated from a rat liver cDNA library

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0271
Volume/Issue:
Volume 204: Issue 3
Free access
Hong Xu Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou, China

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Yang Zhou Liver Cirrhosis Section, Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Yongxia Liu Department of Clinical Laboratory, Hangzhou Red Cross Hospital, Hangzhou, China

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Jian Ping Liver Cirrhosis Section, Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Qiyang Shou Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China

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Fangming Chen Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China

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Ru Ruo Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, China

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Introduction The liver is a primary target organ for insulin and plays a critical role in glucose homeostasis. It maintains a balance between the uptake and storage of glucose by regulating glycogenesis and the production of glucose by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0409
Volume/Issue:
Volume 229: Issue 2
Free access
Wing-Yee Lui Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Yan Ho Cheng Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Dolores D Mruk Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Chin Ho Cheng Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Meng Yun Mo Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Will M Lee Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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C Yan Cheng Population Council, Center for Biomedical Research, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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the liver, and it is one of the major acute-phase serum proteins associated with inflammatory response ( Kushner 1982 ). Serum α 2 -MG is also capable of binding to a broad spectrum of cytokines, such as transforming growth factor ( Huang et al. 1988

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06136
Volume/Issue:
Volume 185: Issue 3
Free access
Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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glucocorticoids can have sexually dimorphic actions ( Duma et al . 2010 , Quinn & Cidlowski 2016 ). For example, in the liver the synthetic glucocorticoid dexamethasone differentially affects expression of many GR target genes in male vs female rats ( Duma et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
Free access
Johan Svensson
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Jon Kindblom Division of Endocrinology, Department of Oncology, Department of Physiology/Endocrinology, Laboratory for Experimental Medicine and Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg University, Gröna Stråket 8, SE-413 45 Göteborg, Sweden

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Ruijin Shao Division of Endocrinology, Department of Oncology, Department of Physiology/Endocrinology, Laboratory for Experimental Medicine and Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg University, Gröna Stråket 8, SE-413 45 Göteborg, Sweden

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Sofia Movérare-Skrtic
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Marie K Lagerquist
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Niklas Andersson
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Klara Sjögren
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Katrien Venken Division of Endocrinology, Department of Oncology, Department of Physiology/Endocrinology, Laboratory for Experimental Medicine and Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg University, Gröna Stråket 8, SE-413 45 Göteborg, Sweden

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Dirk Vanderschueren Division of Endocrinology, Department of Oncology, Department of Physiology/Endocrinology, Laboratory for Experimental Medicine and Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg University, Gröna Stråket 8, SE-413 45 Göteborg, Sweden

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John-Olov Jansson
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Olle Isaksson
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Claes Ohlsson
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IGF1 is liver derived ( Sjögren et al . 1999 , Yakar et al . 1999 ). A mouse model with liver-specific, inducible inactivation of the Igf1 gene, using the Cre-LoxP conditional knockout system, has been developed (LI-IGF1 −/− mice; Sjögren et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0406
Volume/Issue:
Volume 199: Issue 3
Free access