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K J Oldknow Developmental Biology, The Roslin Institute, Edinburgh, UK

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V E MacRae Developmental Biology, The Roslin Institute, Edinburgh, UK

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C Farquharson Developmental Biology, The Roslin Institute, Edinburgh, UK

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, regulating glucose homoeostasis, carbohydrate, lipid and protein metabolism, and promoting cell division and growth through its mitogenic effects (reviewed in Wilcox (2005) ); thus, insulin regulates whole-body energy utilisation, mediating its downstream

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0584
Volume/Issue:
Volume 225: Issue 1
Free access
Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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The gut microbiota and microbiome and the control of metabolism Research started several decades ago, but bloomed only since the beginning of the new century, has provided uncontroversial evidence that the complex ecosystem known as the gut

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-20-0444
Volume/Issue:
Volume 248: Issue 2
Free access
Elisa Villalobos University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Allende Miguelez-Crespo University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth A Morgan University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Scotland’s Rural College, The Roslin Institute, Easter Bush Campus, United Kingdom

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Lisa Ivatt University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Mhairi Paul University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Joanna P Simpson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Natalie Z M Homer University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Dominic Kurian The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Judit Aguilar The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Rachel A Kline The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Thomas M Wishart The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Nicholas M Morton University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Centre for Systems Health and Integrated Metabolic Research, Nottingham Trent University, Nottingham, United Kingdom

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Roland H Stimson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth Andrew University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Mark Nixon University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Abcc1 -deficient mice on HFD, we explored other mechanisms that might explain their adverse glucose metabolism phenotype. Transcriptomic and proteomic analyses reveal differential responses to high-fat diet in adipose tissue from Abcc1 -deficient

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0024
Volume/Issue:
Volume 262: Issue 2
Open access
Srilaxmi Kalavalapalli Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Fernando Bril Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Joy Guingab Department of Pathology, University of Florida, Gainesville, Florida, USA

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Ariana Vergara Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Timothy J Garrett Department of Pathology, University of Florida, Gainesville, Florida, USA

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Nishanth E Sunny Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA

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Kenneth Cusi Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA
Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veterans Administration Medical Center (VAMC), Gainesville, Florida, USA

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Introduction Nonalcoholic fatty liver disease (NAFLD) is characterized by intrahepatic triglyceride accumulation, hepatic insulin resistance and dysregulated mitochondrial metabolism. About 70% of patients with obesity or type 2 diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0007
Volume/Issue:
Volume 241: Issue 3
Free access
Huanan Zhang School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai, China
Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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John R Speakman Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
Institute of Health Sciences, China Medical University, Shenyang, Liaoning, China

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. 1977 ). The half-life of caffeine elimination is about 3–4 h in adults. No differences in the metabolism of caffeine are observed between men and women or with age ( Patwardhan et al. 1980 , Aldridge et al. 1981 ). For example, the pharmacokinetics

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0075
Volume/Issue:
Volume 262: Issue 3
Restricted access
Yu Wu Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Tingting Wu Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Jun Wu Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Lei Zhao Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Qing Li Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Zac Varghese Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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John F Moorhead Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Stephen H Powis Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Yaxi Chen Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Xiong Z Ruan Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Key Laboratory of Metabolism of Lipid and Glucose, John Moorhead Research Laboratory, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

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aggravated insulin resistance and glucose metabolism disorders in HFD-fed C57BL/6J mice The fasting glucose levels were unchanged in HFD-fed mice compared with NCD-fed mice ( Fig. 2 A and C). After glucose challenge, blood glucose concentration of HFD group

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0160
Volume/Issue:
Volume 219: Issue 3
Free access
James Cantley Division of Systems Medicine, School of Medicine, University of Dundee, UK

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Vincent Poitout Montreal Diabetes Research Center, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Department of Medicine, Université de Montréal, Montréal, QC, Canada

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Rebecca L Hull-Meichle Research and Development Service, VA Puget Sound Health Care System, Seattle, Washington, USA
Department of Medicine, University of Washington, Seattle, Washington, USA

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Glucagon, the principal hormone produced by pancreatic islet alpha (α) cells, has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Accordingly, glucagon has been utilised as a

Article Type:
Editorial
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0138
Volume/Issue:
Volume 258: Issue 3
Free access
David M Cartwright Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Lucy A Oakey Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Rachel S Fletcher Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Craig L Doig Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
School of Science and Technology, Nottingham Trent University, Nottingham, UK

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Silke Heising Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Dean P Larner Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Daniela Nasteska Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Caitlin E Berry Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Sam R Heaselgrave Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Christian Ludwig Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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David J Hodson Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Antje Garten Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Pediatric Research Center, Hospital for Child and Adolescent Medicine, Leipzig University, Leipzig, Germany

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metabolic and mitochondrial disorders. Beneficial effects on energy metabolism and mitochondrial function were found in animal models of diet-induced obesity ( Yoshino et al. 2011 , Cantó et al. 2012 , Yoon et al. 2015 , Mills et al. 2016 , de

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0123
Volume/Issue:
Volume 251: Issue 1
Open access
Stuart A Morgan Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Zaki K Hassan-Smith Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Craig L Doig Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Mark Sherlock Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Paul M Stewart Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK
School of Medicine, Worsley Building, University of Leeds, Leeds, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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availability and action depend not only on circulating levels, but also on the tissue-specific intracellular metabolism by 11β-hydroxysteroid dehydrogenases (11β-HSDs) ( Stewart & Krozowski 1999 ). Skeletal muscle expresses 11β-hydroxysteroid dehydrogenase type

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0011
Volume/Issue:
Volume 229: Issue 3
Free access
J Kwakkel
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O Chassande Department of Endocrinology and Metabolism, Academic Medical Center University of Amsterdam, INSERM U 577, Université Victor Segalen Bordeaux 2, F5-165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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H C van Beeren
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W M Wiersinga
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A Boelen
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in diminished downregulation of liver D1 mRNA expression and activity induced by LPS. In this study, we used TRβ −/− mice to evaluate the role of TRβ in LPS-induced changes in thyroid hormone metabolism. Materials and Methods Animal experiments Male

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0601
Volume/Issue:
Volume 197: Issue 1
Free access