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Kotaro Azuma Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Stephanie C Casey Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Masako Ito Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Tomohiko Urano Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Kuniko Horie Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Yasuyoshi Ouchi Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Séverine Kirchner Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Bruce Blumberg Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Satoshi Inoue Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Department of Geriatric Medicine, Department of Developmental and Cell Biology, Division of Radiology, Department of Anti-Aging Medicine, Division of Gene Regulation and Signal Transduction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Introduction The steroid and xenobiotic receptor (SXR) and its murine ortholog pregnane X receptor (PXR) (also known as PAR and NR1I2) are nuclear receptors that are activated by various endogenous and dietary substances, pharmaceutical agents, and

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DOI:
https://doi.org/10.1677/JOE-10-0208
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Volume 207: Issue 3
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G M Ledda-Columbano Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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A Perra Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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M Pibiri Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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F Molotzu Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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A Columbano Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy

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). Most of these actions are mediated by thyroid hormone ( l -tri-iodothyronine; T3) nuclear receptors (TRs) that are encoded by two genes (α and β) and are expressed as several isoforms ( Cheng 1995 , Lazar 1993 , Hoppenheimer et al. 1996 , Yen 2001

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https://doi.org/10.1677/joe.1.06110
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Volume 185: Issue 3
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Luana Lopes Souza
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Aline Cordeiro
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Lorraine Soares Oliveira
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Gabriela Silva Monteiro de Paula
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Larissa Costa Faustino
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Tania Maria Ortiga-Carvalho
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Karen Jesus Oliveira Biophysics Institute Carlos Chagas Filho, Department of Physiology and Pharmacology, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Carmen Cabanelas Pazos-Moura
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agonists ( Johansson et al . 2005 ) or transgenic models with mutations of TRβ ( Gullberg et al . 2000 , 2002 , Hashimoto et al . 2006 ). TR belongs to the superfamily of nuclear receptors and TR functional interactions with such nuclear receptors have

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https://doi.org/10.1530/JOE-11-0142
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Volume 211: Issue 1
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Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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steroid nuclear receptor subfamily ( Chen et al . 1997 , Mifsud & Reul 2016 ). All six nuclear steroid receptors, including the GR and the AR, originate from a common ancestral receptor gene ( Thornton 2001 ), which underlies the substantial homology in

Article Type:
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DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
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Noriko Sakai
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Hiromi Terami
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Shinobu Suzuki
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Megumi Haga
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Ken Nomoto
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Nobuko Tsuchida
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Ken-ichirou Morohashi Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Naoaki Saito Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Maki Asada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Megumi Hashimoto Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Daisuke Harada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Hiroshi Asahara Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Tetsuya Ishikawa
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Fumiki Shimada
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Kazuhiro Sakurada
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-producing cells in vitro . To achieve this, nuclear receptor subfamily 5, group A, member 1 ( NF5A1 that was previously known as SF-1 or AD4BP ) is a key molecule. NF5A1 is the steroidogenic tissue-specific transcription factor that controls the expression

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DOI:
https://doi.org/10.1677/JOE-08-0027
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Volume 198: Issue 3
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Tony K S Ku University of Illinois Cancer Center, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois 60612, USA

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David L Crowe University of Illinois Cancer Center, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois 60612, USA

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cofactors interact with ERα to regulate transcriptional repression or activation. Among the repressive cofactors is nuclear receptor corepressor (NCoR), which interacts with ERα in the presence of the anti-estrogen 4-hydroxytamoxifen (TAM; Huang et al

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https://doi.org/10.1677/JOE-06-0029
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Volume 193: Issue 1
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P Venditti
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G Chiellini Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy

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L Di Stefano
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G Napolitano
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R Zucchi Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy

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A Columbano Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy

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T S Scanlan Dipartimento delle Scienze Biologiche, Dipartimento di Scienze dell'Uomo e dell'Ambiente, Department of Toxicology, Departments of Physiology and Pharmacology and Cell and Developmental Biology, Sezione di Fisiologia, Università di Napoli ‘Federico II’, Via Mezzocannone 8, I-80134 Napoli, Italy

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S Di Meo
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M Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis . Cell 92 829 – 839 . Ragan MT Wilson VM Darley-Usmar PN Lowe PN 1987 Sub-fractionation of mitochondria and isolation of

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https://doi.org/10.1677/JOE-10-0036
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Volume 205: Issue 3
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P Froment INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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F Gizard INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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D Defever INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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B Staels INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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J Dupont INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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P Monget INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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Introduction PPARγ is a nuclear receptor of the peroxisome proliferator-activated receptor family, which also includes PPARα and PPARβ/δ (for review, see Sorensen et al. 1998 , Desvergne & Wahli 1999 ). PPARγ is activated after

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06667
Volume/Issue:
Volume 189: Issue 2
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María Sol Kruse Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina

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Mariana Rey Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina

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María Cristina Vega Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina

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Héctor Coirini Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina
Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina
Laboratorio de Neurobiología, Departamento de Bioquímica Humana, Facultad de Ciencias Medicas, Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires (C1428ADN), Buenos Aires, Argentina

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Introduction Liver X receptor (LXR) α and β are ligand-activated transcription factors that belong to the nuclear receptor superfamily. Both LXRs are key sensors of intracellular sterol levels that trigger various adaptive mechanisms in response to

Article Type:
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DOI:
https://doi.org/10.1530/JOE-12-0088
Volume/Issue:
Volume 215: Issue 1
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Juan Bernal Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, and Center for Biomedical Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain

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via binding to the nuclear receptors (TRs), which function as ligand-activated transcription factors. The two TR genes, THRA and THRB, encode three proteins with full receptor function at the genomic level: TRα1, TRβ1 and TRβ2. In addition, there are

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0424
Volume/Issue:
Volume 232: Issue 2
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