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Z Zhang Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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P H Bisschop Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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E Foppen Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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H C van Beeren Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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A Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), Amsterdam, Amsterdam, the Netherlands

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A Boelen Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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E Fliers Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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Introduction Thyroid hormone (TH) is a major determinant of basal metabolic rate as well as glucose and lipid metabolism ( Mullur et al . 2014 , Sinha et al . 2014 ). A number of recent studies have shown that in addition to the well

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0501
Volume/Issue:
Volume 229: Issue 1
Free access
Joke Delbaere Laboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Leuven, Belgium

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Pieter Vancamp Laboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Leuven, Belgium

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Stijn L J Van Herck Laboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Leuven, Belgium

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Nele M A Bourgeois Laboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Leuven, Belgium

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Mary J Green Medical Research Council Centre for Developmental Neurobiology, King’s College London, London, UK

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Richard J T Wingate Medical Research Council Centre for Developmental Neurobiology, King’s College London, London, UK

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Veerle M Darras Laboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Leuven, Belgium

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Introduction Thyroid hormones (THs) play an important role in the functional organisation of the cerebellum. Distinct cerebellar cell types depend on adequate TH levels as well as a correct timing of TH access to coordinate key cellular events

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0323
Volume/Issue:
Volume 232: Issue 2
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Michael Muchow
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Ioannis Bossis
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Tom E Porter
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Introduction Thyroid hormones are involved in the regulation of growth, metabolism, heat production, gonadal development, molting, migration, and hatching in birds ( McNabb 2000 ). Thyroid-stimulating hormone (TSH) plays an important

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05944
Volume/Issue:
Volume 184: Issue 2
Free access
Nicolás Gigena Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Vanina A Alamino Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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María del Mar Montesinos Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Magalí Nazar Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Ruy A Louzada Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Rio de Janeiro, Brazil

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Simone M Wajner Thyroid Unit, Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana L Maia Thyroid Unit, Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana M Masini-Repiso Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Denise P Carvalho Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Rio de Janeiro, Brazil

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Graciela A Cremaschi Laboratorio de Neuroinmunomodulación y Oncología Molecular, Instituto de Investigaciones Biomédicas (BIOMED-CONICET), Universidad Católica Argentina, Ciudad Autónoma de Buenos Aires, Argentina

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Claudia G Pellizas Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Introduction Thyroid hormones (THs) are critical regulators of cellular differentiation, growth and metabolism. The thyroid secretes 100% of circulating thyroxine (T 4 ). However, it provides a low percentage of serum levels of the most

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0423
Volume/Issue:
Volume 232: Issue 2
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Stefan Groeneweg Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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Robin P Peeters Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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Theo J Visser Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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W Edward Visser Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands

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Introduction Thyroid hormone (TH) is crucial for the development and metabolism of many tissues. Thyroid stimulating hormone (TSH) controls the production and secretion of TH by the thyroid gland, which predominantly produces the pro

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0113
Volume/Issue:
Volume 234: Issue 2
Free access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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thyroid hormones. Studies in rats on the existence of a daily oscillating pattern of thyroid hormones in the circulation have, however, not been quite unequivocal, although most favour a diurnal peak of thyroxin (T4) and triiodothyronine (T3) during the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0111
Volume/Issue:
Volume 233: Issue 3
Open access
J. A. Franklyn
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J. R. E. Davis
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D. B. Ramsden
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M. C. Sheppard
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ABSTRACT

Circulating free thyroid hormone concentrations are reduced in subjects taking long-term phenytoin, a finding at variance with their euthyroid clinical state and normal serum TSH concentration. It is suggested, therefore, that phenytoin may modify the cellular effects of thyroid hormones.

In order to examine the influence of phenytoin on thyroid hormone action in the pituitary gland we studied its effect on the binding of tri-iodothyronine (T3) to isolated nuclei prepared from rat anterior pituitary tissue. Phenytoin inhibited the nuclear binding of T3 in a dose-dependent fashion. Phenytoin also partially inhibited thyrotrophin-releasing hormone-stimulated TSH release from cultured rat anterior pituitary cells. These studies provide evidence for a direct effect of phenytoin on the thyrotroph mediated via nuclear T3 receptor binding.

J. Endocr. (1985) 104, 201–204

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.1040201
Volume/Issue:
Volume 104: Issue 2
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Clare F Hodkinson Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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Ellen E A Simpson Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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John H Beattie Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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Jacqueline M O'Connor Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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David J Campbell Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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J J Strain Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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Julie M W Wallace Northern Ireland Centre for Food and Health (NICHE), School of Psychology, Rowett Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK

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, predominantly from animal studies, also suggests a direct reciprocal relationship exists between the thyroid gland and the immune system ( Fabris et al . 1995 , Klein 2006 ). Thyroid hormones are involved in numerous physiological processes, such as

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0488
Volume/Issue:
Volume 202: Issue 1
Free access
Anita Boelen Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Anne H van der Spek Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Flavia Bloise Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Emmely M de Vries Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Olga V Surovtseva Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Mieke van Beeren Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Mariette T Ackermans Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Joan Kwakkel Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Introduction During illness, thyroid hormone metabolism changes profoundly. Serum thyroid hormones decrease and the classical negative feedback loop of the hypothalamic–pituitary–thyroid axis is absent. This is known as the nonthyroidal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0483
Volume/Issue:
Volume 233: Issue 1
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Marcelo A Christoffolete
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Márton Doleschall Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Péter Egri Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Zsolt Liposits Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Ann Marie Zavacki Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Antonio C Bianco Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Balázs Gereben Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Introduction Thyroid hormone receptor (TR) and liver X-receptors (LXRs) are the key regulators of lipid metabolism. Both these receptors prefer to bind to a direct repeat of the consensus DNA-binding site separated by a 4 bp spacing (DR-4), and thus

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0448
Volume/Issue:
Volume 205: Issue 2
Free access