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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto

increase hybrid vigor as well as the increasing use of the Cre/LoxP system (which requires a tissue-specific Cre expressing and a LoxP-containing gene targeted mouse), the result0ant genetically modified mouse is frequently a conglomeration of two or more

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Jennifer J DuPont and Iris Z Jaffe

for MR in the vasculature. These mouse models were created by engineering mice with loxP sites flanking the MR gene via homologous recombination in ES cells ( Metzger et al. 1995 ). Specifically, Cre-Lox technology has significantly advanced our

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J Svensson, M Diez, J Engel, C Wass, Å Tivesten, J-O Jansson, O Isaksson, T Archer, T Hökfelt, and C Ohlsson

, using the Cre-LoxP conditional knockout system (LI-IGF-I −/− mice) ( Sjögren et al. 1999 , 2001 , 2002 , Wallenius et al. 2001 , Tivesten et al. 2002 ), has made it possible to investigate the role of liver-derived IGF-I in adult mice. These

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João A B Pedroso, Pedro O R de Mendonca, Marco A S Fortes, Igor Tomaz, Vitor L Pecorali, Thais B Auricino, Ismael C Costa, Leandro B Lima, Isadora C Furigo, Debora N Bueno, Angela M Ramos-Lobo, Claudimara F P Lotfi, and Jose Donato Jr

muscle ( Spangenburg et al . 2006 , Trenerry et al . 2007 , Begue et al . 2013 ). Since whole-body SOCS3-knockout mice exhibit embryonic lethality ( Roberts et al . 2001 ), we employed the Cre-loxP system to produce tissue-specific SOCS3 ablation

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Hen Prizant, Norbert Gleicher, and Aritro Sen

androgens to estrogen. AR knockout mouse models Earlier, it was believed that androgens affect ovarian function either by acting as a precursor of steroidogenesis (specifically by aromatization to estrogen) or by indirect effects mediated by the hypothalamus

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Gabriel O de Souza, Fernanda M Chaves, Josiane N Silva, João A B Pedroso, Martin Metzger, Renata Frazão, and Jose Donato

mice carrying loxP-flanked Gja1 alleles (The Jackson Laboratory; Stock No: 008039). All mice used in the experiments were homozygous for the loxP-flanked Gja1 allele, whereas the conditional knockout mice (AgRP-specific CX43 knockout (AgRP ΔCX43

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Jethro S Johnson, Monica N Opiyo, Marian Thomson, Karim Gharbi, Jonathan R Seckl, Andreas Heger, and Karen E Chapman

bowel diseases . Molecular and Cellular Endocrinology 301 104 – 108 . ( doi:10.1016/j.mce.2008.10.030 ) Tang SH Silva FJ Tsark WM Mann JR 2002 A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ . Genesis 32 199

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Ferran Jardí, Michaël R Laurent, Vanessa Dubois, Nari Kim, Rougin Khalil, Brigitte Decallonne, Dirk Vanderschueren, and Frank Claessens

. The ultimate proof of the role of ERs on male physical activity comes from studies in knockout mice lacking ERα or the aromatase enzyme (see discussion in the ‘Global KO mouse models’ section). Androgenic-anabolic steroids (AAS) and selective

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Rachel A Davey, Michele V Clarke, Suzanne B Golub, Patricia K Russell, and Jeffrey D Zajac

and Mineral Research 27 1018 – 1029 . ( https://doi.org/10.1002/jbmr.1567 ) Schwenk F Baron U Rajewsky K 1995 A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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Chiung-Kuei Huang, Soo Ok Lee, Eugene Chang, Haiyan Pang, and Chawnshang Chang

directly address the AR effects on CVDs. Using the Cre-LoxP strategy, several mouse models with knockout of Ar in the whole body or in specific cell types, including general ARKO (GARKO, knockout in whole body), neuronal cell ARKO (NARKO) ( Yu et al