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Stephanie L Clookey Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Rebecca J Welly Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Terese M Zidon Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Michelle L Gastecki Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Makenzie L Woodford Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Zachary I Grunewald Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Nathan C Winn Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Dusti Eaton Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Natalia G Karasseva Transgenic Animal Core, University of Missouri, Columbia, Missouri, USA

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Harold S Sacks Endocrine and Diabetes Division, Veterans Greater Los Angeles Healthcare System, Los Angeles, California, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Child Health, University of Missouri, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Altirriba J Montet X Colin DJ Caillon A Lyautey J Rohner-Jeanrenaud F 2015 Ectopic UCP1 overexpression in white adipose tissue improves insulin sensitivity in Lou/C Rats, a Model of Obesity Resistance Lou . Diabetes 64 3700 – 3712 . ( https

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Mariana Renovato Martins Department of Physiology, Biology Institute, State University of Rio de Janeiro, Avenue 28 de Setembro, 87-Fundos, 5° andar, Rio de Janeiro 20550-030, Brazil

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Anatalia Kutianski Gonzalez Vieira Department of Physiology, Biology Institute, State University of Rio de Janeiro, Avenue 28 de Setembro, 87-Fundos, 5° andar, Rio de Janeiro 20550-030, Brazil

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Érica Patrícia Garcia de Souza Department of Physiology, Biology Institute, State University of Rio de Janeiro, Avenue 28 de Setembro, 87-Fundos, 5° andar, Rio de Janeiro 20550-030, Brazil

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Anibal Sanchez Moura Department of Physiology, Biology Institute, State University of Rio de Janeiro, Avenue 28 de Setembro, 87-Fundos, 5° andar, Rio de Janeiro 20550-030, Brazil

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 mg/ml aprotinin, 5 mg/ml leupeptin, and 1 mM phenylmethylsulfonyl fluoride. The homogenates were then centrifuged at 400  g for 15 min at 4 °C. Pellets were discarded and supernatants frozen at −20 °C. Immunoprecipitation For immunoprecipitation

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Xiaofeng Ding Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan, China

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Yan Luo Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

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Xing Zhang Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

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Handong Zheng Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

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Xin Yang Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

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Xuexian Yang Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

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Meilian Liu Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

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mice. The ob/ob heterozygous mice were only used for the generation of experimental mice but not for the following experiments. Six-week-old male C57BL/6 mice were fed either a normal chow diet (NCD) or HFD (45% kcal from fat, D12451; Research Diets

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Nigel Irwin School of Biomedical Sciences, The SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Pamela Frizelle School of Biomedical Sciences, The SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Finbarr P M O'Harte School of Biomedical Sciences, The SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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Peter R Flatt School of Biomedical Sciences, The SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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hormone ( Mutt & Jorpes 1968 ) that was shown to release pancreatic amylase and other enzymes ( Mutt 1980 ). However, CCK is now known to exist in a number of molecular isoforms, of which the C-terminal octapeptide (CCK-8) represents the most abundant

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M M Conradie
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H de Wet
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D D R Kotze
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J M Burrin
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F S Hough
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P A Hulley
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IU/kg vitamin D). Treatment groups ( n =10) over 9 weeks were as follows: C, sham-injected once daily, 5 days/week; S, 3.5 mg/kg per day methylprednisolone (Solumedrol) injected subcutaneously; V, 0.5 mg/ml sodium orthovanadate continuously in

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Ying Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Nan Meng Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haili Bao Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Yufei Jiang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Ningjie Yang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Kejia Wu Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Jinxiang Wu Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haibin Wang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Shuangbo Kong Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Yuanzhen Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Dulbecco’s phosphate-buffered saline (DPBS) washes, the cells were scraped and centrifuged for 5 min at 700  g and 4°C. The sediment was resuspended in 1 mL of lysis buffer 1 (0.25% Triton X-100, 0.5% NP-40, 10% glycerol, 1 mM EDTA, 50 mM HEPES and 140

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Manuel D Gahete Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Juan M Jiménez-Vacas Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Emilia Alors-Pérez Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Vicente Herrero-Aguayo Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Antonio C Fuentes-Fayos Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Sergio Pedraza-Arévalo Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Justo P Castaño Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Raúl M Luque Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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)  Cdkn1b +/− Somatotropinoma Heterozygous knockout Cdkn1b Fero et al. (1996), Kiyokawa et al. (1996), Nakayama et al. (1996)  Prkar1a +/− Somatotropinoma Heterozygous knockout Prkar1a Yin et al. (2008)  p18 INK4c

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Jie Xu INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Amaury Jean-Marie Bekaert INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Joëlle Dupont INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Sarah Rouve INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Isabella Annesi-Maesano INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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C Daniel De Magalhaes Filho INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Laurent Kappeler INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Martin Holzenberger INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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pulsatile secretion and increased orexigenic peptide expression in the Lou C/JaLL rat . Neuroendocrinology 80 273 – 283 doi:10.1159/000083610 . Kappeler L De Magalhaes Filho C Dupont J Leneuve P Cervera P Périn L Loudes C Blaise A Klein

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Zerui Wu Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Lin Cai Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Jianglong Lu Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Chengde Wang Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Jiaqing Guan Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Xianbin Chen Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Jinsen Wu Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Weiming Zheng Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Zhebao Wu Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Qun Li Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Zhipeng Su Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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cultured cells in a 5% CO 2 atmosphere at 37°C. In addition, siRNA of Becn1 , miRNA-93-5p inhibitor, miRNA-93-5p mimic and corresponding negative control were purchased from GenePharma (Shanghai, China) ( Table 1 ). Hereinafter, miRNA-93 is specifically

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Yi Lin Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

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Zhongjie Sun Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

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remodeling actin cytoskeleton. Docking: GLUT4 vesicles bind to plasma membrane via interaction of VAMP2 with target-SNARE complexes. Fusion: irreversible incorporation of GLUT4 vesicles on to plasma membrane is enhanced through action of Munc18c on SNARE

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