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Hiroyuki Otani
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Fumio Otsuka
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Masaya Takeda
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Tomoyuki Mukai
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Tomohiro Terasaka
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Tomoko Miyoshi
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Kenichi Inagaki
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Jiro Suzuki
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Toshio Ogura
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Mark A Lawson Department of Medicine and Clinical Science, Department of Reproductive Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama City 700-8558, Japan

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Hirofumi Makino
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anti-phospho- and anti-total-extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) antibody (Cell Signaling Technology, Inc., Beverly, MA, USA), anti-phospho- and anti-total-p38 MAPK antibody (Cell Signaling Technology

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0065
Volume/Issue:
Volume 203: Issue 1
Free access
XueJing Zhang
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JianHua Li State Key Laboratory of Agrobiotechnology, Center of Reproductive Medicine and Genetics, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan Xilu, Beijing 100193, People's Republic of China

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JiaLi Liu
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HaoShu Luo
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KeMian Gou
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Sheng Cui
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). These data reveal that PGF 2 α upregulates the expression of Slit2 and Robo1 in a dose-dependent and time-dependent manner. PGF 2 α specifically increases Slit2/Robo1 expression through PKC-dependent ERK1/2 and P38 MAPK signaling

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0088
Volume/Issue:
Volume 218: Issue 3
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Bethany R L Aykroyd Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Simon J Tunster Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Amanda N Sferruzzi-Perri Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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related to changes in the expression of signaling components downstream of IGF2, we quantified the mRNA expression of IGF2 receptors, Igf1r , Igf2r and Insr , as well as PI3K-AKT ( P85 , P110α , P110β , Akt and Gsk3 ) and RAS-MAPK-ERK ( H-ras , N

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0128
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Volume 246: Issue 1
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T Nanmoku Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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K Takekoshi Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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T Fukuda Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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K Ishii Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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K Isobe Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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Y Kawakami Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

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catecholamine secretion via the PKA pathway, but not the mitogenic effects in chromaffin cells ( Nanmoku et al. 2003 ). However, it is not known whether PrRPs influence the biosynthesis of catecholamine in chromaffin cells. The signal transduction

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05919
Volume/Issue:
Volume 186: Issue 1
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Xiaohui Wang
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Yuxia Chen
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Yan Wang
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Xiaoyan Zhu
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Yuanyuan Ma
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Shimin Zhang Department of Pathophysiology, American Registry of Pathology at Armed Forces Institute of Pathology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China

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Jian Lu
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nitrocellulose membrane, which were then blocked with 5% nonfat milk and probed overnight with antibodies against Rhob (1:200), GR (1:1000), total and phosphorylated MAPK3/1, MAPK14, phosphorylated Akt (1:500), or β-actin (1:10 000). Then the membranes were

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0340
Volume/Issue:
Volume 200: Issue 1
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Shaodong Guo Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M University Health Science Center, Scott & White, Central Texas Veterans Health Care System, 1901 South 1st Street, Bldg. 205, Temple, Texas 76504, USA

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the activation of both the Ras→MAPKs and phosphatidylinositide-3-kinase (PI3K)→Akt signaling cascade ( White 2003 ). IR and its homologous insulin-like growth factor 1 receptor (IGF1R) can also form heterodimers (IR/IGF1R) that modulate the selectivity

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0327
Volume/Issue:
Volume 220: Issue 2
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Shan-Jin Wang Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Xin-Feng Li Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Lei-Sheng Jiang Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Li-Yang Dai Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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signaling pathways including the JAK1/STAT1 pathway and the phosphatidylinositol 3-kinase (PI3K (PIK3R1))/MAPK1 pathway, both of which can mediate the differentiation of chondrocytes ( Fruhbeck 2006 , Ben-Eliezer et al . 2007 , Gat-Yablonski & Phillip

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0353
Volume/Issue:
Volume 213: Issue 2
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Liat Abovich Gilad Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

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Tali Bresler Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

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Julia Gnainsky Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

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Patricia Smirnoff Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

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Betty Schwartz Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

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). Detailed mechanisms whereby MAPK activation mediates E2 gene regulation remain speculative. The present study was designed to investigate the nature of the interactions between E2, the MAPK signaling pathway, and VDR in cells representative of various

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05770
Volume/Issue:
Volume 185: Issue 3
Free access
Audrey Lamirand INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France

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Martine Ramaugé INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France

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Michel Pierre INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France

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Françoise Courtin INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France
INSERM UMR 788, INSERM UMR 854, University Paris-Sud 11, Stéroïdes, neuroprotection et neurogénération, 94275 Le Kremlin-Bicêtre cedex, France

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. 2006 , Freitas et al . 2010 ). NF-κB is a transcription factor which is classically involved in LPS signaling pathways ( Chen & Greene 2004 ). An NF-κB inhibitor, i.e. sulfasalazine, partially inhibits LPS-induced D2 activity in human mesothelioma

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0218
Volume/Issue:
Volume 208: Issue 2
Free access
Raúl M Luque Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain
Hospital Universitario Reina Sofia (HURS), Cordoba, Spain
CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

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Rhonda D Kineman Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago and Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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inhibitors to various intracellular signaling pathways previously shown to be important in the actions of SST (adenylyl cyclase (AC), protein kinase A (PKA), phospholipase C (PLC), protein kinase C (PKC), extracellular Ca 2+ L-type channels, intracellular Ca

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0135
Volume/Issue:
Volume 237: Issue 3
Free access