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with changes in the activity of integrative sensors like 5′-AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), is associated with the inhibition of the orexigenic factors AgRP and NPY and the enhancement of the anorexigenic factors POMC and CART
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resistance in starvation may result from a decrease in STAT5 phosphorylation, mediated by fibroblast growth factor 21 (FGF21) and/or Sirtuin 1 (SIRT1). States of malnutrition A number of models of malnutrition have been studied to better understand the state
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, Danvers, MA, USA, #3661), PGC1α (Calbiochem, Billerica, MA, USA, #516557), PPARα (Abcam, Cambridge, UK, #8934), sirtuin-1 (SIRT1) (Cell Signalling, #2310) and housekeeping protein cyclophilin-B (Abcam, #74173) were diluted in Tris-buffered saline (TBS) and
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death 4; PDK1, phosphoinositide-dependent protein kinase 1; Rab27a, member RAS oncogene family; Sirt1, sirtuin (silent mating type information regulation 2 homolog) 1; Vamp2, vesicle-associated membrane protein 2; UCP2, uncoupling protein 2. miRNAs alter
ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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worm, yet its similarity to the mammalian Homo sapiens SIRT-1 proteins suggests that it may involve deacetylation in Lys residues ( Daitoku et al. 2004 ). Indeed, transgenic expression of sir-2.1 increases the lifespan of C. elegans up to 50% in
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interconverted between its oxidized (NAD + ) and reduced (NADH) forms. However, NAD + may also function as a cell signaling molecule via roles in PTMs; ADP-ribosylation and NAD + -dependent deacetylation. For example, NAD + activates sirtuin 1 (SIRT1
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( Zhang et al. 2015 b , Zhang & Choudhury 2017 ). Additionally, levels of sirtuins (SIRT) 1 and 3, two NAD + -dependent deacetylases with different roles in the control of mitochondrial biogenesis ( Nogueiras et al. 2012 ), were also decreased
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53 1087 – 1097 . ( doi:10.1369/jhc.5C6684.2005 ) Cao Y Xue Y Xue L Jiang X Wang X Zhang Z Yang J Lu J Zhang C Wang W 2013 Hepatic menin recruits SIRT1 to control liver steatosis through histone
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-phosphorylated and -regulated kinase 1A; Ub, ubiquitin; SIRT2, NAD + -dependent histone deacetylase silent information regulator 2; CBP, CREB-binding protein; p300, global transcription factor cofactor; P, phosphorylation; Me, methylation; G, glycosylation; Ac
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
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(version 6.0, Media Cybernetics). Luciferase assays of promoter activities for Nrf2/ARE, SIRT1 and PGC-1α Luciferase assays were performed as described elsewhere ( Lee et al. 2014 , Li et al. 2015 ). ARE- bla construct was used for Nrf2/ARE