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J Jeyabalan
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M Shah
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B Viollet Royal Veterinary College, Institut Cochin, Royal College Street, London NW1 0TU, UK

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C Chenu
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adipose tissue, α1 subunit is the dominant catalytic isoform expressed in bone, suggesting that it may play a major function in skeletal metabolism. Using both RT-PCR and western blot analysis, it was shown that α1 subunit is highly expressed in bone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0306
Volume/Issue:
Volume 212: Issue 3
Free access
Madhusmita Misra BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Anne Klibanski BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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). Increased marrow adiposity in AN is associated with lower aBMD ( Bredella et al . 2009 ), consistent with the reports of a reciprocal relationship between marrow fat and bone in studies of healthy children and adults ( Lewiecki et al . 2008 ). Preadipocyte

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0039
Volume/Issue:
Volume 221: Issue 3
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Katie J Mylonas University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Neil A Turner Division of Cardiovascular & Diabetes Research, Leeds Institute of Cardiovascular & Metabolic Medicine (LICAMM), School of Medicine, University of Leeds, Leeds, UK

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Sumia A Bageghni Division of Cardiovascular & Diabetes Research, Leeds Institute of Cardiovascular & Metabolic Medicine (LICAMM), School of Medicine, University of Leeds, Leeds, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Christopher I White University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Kieran McGregor University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Robert A Kimmitt University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Richard Sulston University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Valerie Kelly University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Brian R Walker University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Porter Division of Cardiovascular & Diabetes Research, Leeds Institute of Cardiovascular & Metabolic Medicine (LICAMM), School of Medicine, University of Leeds, Leeds, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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1 deficient. In ‘BMKO’ animals, WT recipients received Hsd11b1 −/− bone marrow, resulting in Hsd11b1 −/− neutrophils and WT radio-resistant host tissue. Chimeric animals were housed under pathogen-free conditions in individually ventilated cages

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0501
Volume/Issue:
Volume 233: Issue 3
Open access
M J Devlin Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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C Grasemann Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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A M Cloutier Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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L Louis Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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C Alm Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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M R Palmert Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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M L Bouxsein Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA

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. ( doi:10.1136/bmj.300.6719.230 ) Motyl KJ McCabe LR 2009 Leptin treatment prevents type I diabetic marrow adiposity but not bone loss in mice . Journal of Cellular Physiology 218 376 – 384 . ( doi:10.1002/jcp.21608 ) Ogden CL Carroll MD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0403
Volume/Issue:
Volume 217: Issue 1
Free access
Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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( Camilleri & Acosta 2018 ), such as reducing fat synthesis and increasing energy expenditure in key metabolic organs, such as adipose tissue. Adipose tissue can be further divided into white (WAT) and brown (BAT) adipose tissue, which are distinct in form and

Article Type:
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0503
Volume/Issue:
Volume 249: Issue 2
Open access
Guillaume Mabilleau GEROM Groupe Etudes Remodelage Osseux et biomatériaux, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Université d’Angers, Angers, France

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Marie Pereira Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College London, London, UK

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Chantal Chenu Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

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. Type 2 diabetes mellitus (T2DM) is by far the most common form of DM and is characterised by chronic hyperglycaemia and hyperinsulinaemia mostly caused by insulin resistance (IR) in peripheral tissues such as the liver and muscle. The aetiology of bone

Article Type:
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DOI:
https://doi.org/10.1530/JOE-17-0278
Volume/Issue:
Volume 236: Issue 1
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Timothy J Dreyer Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Jacob AC Keen Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Leah M Wells Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Scott J Roberts Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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, Hong et al. 2022 ). Sclerostin also plays an important role in the regulation of bone marrow adiposity and bone marrow adipose tissue (reviewed by Holdsworth et al. 2019 ). Furthermore, sclerostin indirectly affects bone resorption by upregulating

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0209
Volume/Issue:
Volume 257: Issue 2
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Bernardo Nuche-Berenguer Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Daniel Lozano Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Irene Gutiérrez-Rojas Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Paola Moreno Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Mariñoso Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Pedro Esbrit Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Villanueva-Peñacarrillo Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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bony effect of fat is particularly evident in the bone marrow milieu of aging and osteoporotic subjects, which shows high adiposity and decreased osteoblastic differentiation and bone formation ( Rodriguez et al . 1999 , Verma et al . 2002 , Rosen

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DOI:
https://doi.org/10.1530/JOE-11-0015
Volume/Issue:
Volume 209: Issue 2
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M van de Vyver Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa

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E Andrag Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa

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I L Cockburn Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa

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W F Ferris Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa

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( Pparγ ( Pparg )), which promotes adipogenesis (Nishii et al . 2008). Nishii et al . (2008) demonstrated that treatment of immortalised bone marrow stromal cells (TBR31-2) with the Pparγ agonist troglitazone resulted in a marked decrease in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0425
Volume/Issue:
Volume 223: Issue 2
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Kevin H Tsai ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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Mark S Cooper ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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-HSD1 is indeed cell-specific but also subject to dramatic changes in expression level. Examples of tissues/cell types that express 11β-HSD1 at a significant level include liver and adipose tissue, various cells within skin, osteoblasts (bone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0289
Volume/Issue:
Volume 258: Issue 3
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