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K A Walters, V Rodriguez Paris, A Aflatounian, and D J Handelsman

Oocyte and follicle health Corpora lutea population and ovulation Embryo development Global ARKO Ex1 Shiina et al. (2006) ↓ pups/litter – No change in FSH, LH, E2, testosterone or P4 at proestrus Normal at 8 weeks Total follicle

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Timothy C R Prickett, Graham K Barrell, Martin Wellby, Timothy G Yandle, A Mark Richards, and Eric A Espiner

mouse fetal development: temporal changes in embryos and placenta . Endocrinology 137 817 – 824 . Chanetsa F Hillman LS Thomas MG Keisler DH 2000 Estrogen agonist (zeranol) treatment in a castrated male lamb model: effects on growth and

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Jane A Mitchell, Mark J Paul-Clark, Graham W Clarke, Shaun K McMaster, and Neil Cartwright

-like receptor 3. Nature 413 732 –738. Anderson KV , Bokla L & Nusslein-Volhard C 1985 Establishment of dorsal–ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42 791

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Martha Lappas, Amberlee Mittion, and Michael Permezel

25 6831 – 6843 . Desco MC Asensi A Marquez R Martinez-Valls J Vento M Pallardo FV Sastre J Vina J 2002 Xanthine oxidase is involved in free radical production in type 1 diabetes – protection by allopurinol . Diabetes 51 1118

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Chun Zeng, Xin Yi, Danny Zipris, Hongli Liu, Lin Zhang, Qiaoyun Zheng, Krishnamurthy Malathi, Ge Jin, and Aimin Zhou

IFNγ in the development of this disease ( Campbell et al . 1991 , Nicoletti et al . 1996 ). Complete protection from diabetes was observed when Tnfr1 , but not Tnfr2 was knocked out in NOD mice although the direct effect of TNFR1 on β-cell death

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Antonia Hufnagel, Laura Dearden, Denise S Fernandez-Twinn, and Susan E Ozanne

especially in the face of an adverse maternal (nutritional) environment. The next section describes first the effects of early embryo development in response to maternal hyperinsulinaemia, and then the fetal response to the placental changes and direct

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Robert Opitz, Achim Trubiroha, Claudia Lorenz, Ilka Lutz, Sabine Hartmann, Tobias Blank, Thomas Braunbeck, and Werner Kloas

been obtained in mammalian studies of NIS expression in the kidney. Spitzweg et al. (2001) reported positive detection of NIS mRNA in human kidney by RT-PCR and ribonuclease protection assay, whereas other studies failed to detect NIS in kidney

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J L Crawford, B P Thomson, M F Beaumont, and D C Eckery

bromocriptine (dopamine agonist) resulted in reactivation of the suppressed CL and resumption of the development of the quiescent embryo and subsequent birth in the female Tammar wallaby during lactational, but not seasonal, anoestrous ( Tyndale-Biscoe & Hinds

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Dominique A Glauser and Werner Schlegel

embryonic development. Foxo1 − /− mice embryos are smaller and die at embryonic day 10.5. The primary defect causing lethality in Foxo1 − /− mice is apparently an impaired vascularization. Consistently, experiments in Foxo1 +/− mice embryos have shown

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Yu Zhou, Min Gong, Yingfei Lu, Jianquan Chen, and Rong Ju

). These results highlighted the pivotal role of Sirt3 during the protection of pancreatic beta-cell function against oxidative stress. Maternal androgen treatment was reported to impair pancreatic beta-cell function and promote insulin resistance in both