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Raquel Moral
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Richard Wang
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Irma H Russo
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Coral A Lamartiniere Breast Cancer Research Laboratory, Department of Pharmacology and Toxicology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA

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Julia Pereira
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Jose Russo
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percentage of DAB-positive cells within specific epithelial structures, i.e., TEBs, TD and ducts, Abs, and Lob 1. Data from different groups were analyzed by ANOVA and unpaired t -tests. Determination of gene expression profile by microarrays Total RNA from

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XingJia Wang Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Chwan-Li Shen Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Matthew T Dyson Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Xianling Yin Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Randolph B Schiffer Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Paula Grammas Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Douglas M Stocco Departments of Neuropsychiatry, Garrison Institute on Aging,
Cell Biology and Biochemistry,
Neuropsychiatry, and
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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membrane ( Clark et al. 1994 , Lin et al. 1995 , Wang et al. 1998 , Stocco 2001 ). In testicular Leydig cells, StAR gene expression is primarily regulated by luteinizing hormone (LH), but the mechanisms responsible for LH regulation of StAR gene

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Joshua Columbus Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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YuTing Chiang Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Weijuan Shao Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Nina Zhang Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Dingyan Wang Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Herbert Y Gaisano Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Qinghua Wang Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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David M Irwin Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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Tianru Jin Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Division of Cell and Molecular Biology, Department of Medicine, Division of Endocrinology and Metabolism, Department of Laboratory Medicine and Pathobiology, Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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detection of expression of the Tcf7 , Tcf7l1 , and Lef1 genes are shown in Table 1 . PCR products were purified, inserted into TA cloning vectors, and verified by DNA sequencing. As shown in Fig. 3 , in addition to Tcf7l2 , both Tcf7 and Tcf7l1

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T Bossmar Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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N Osman Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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E Zilahi Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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M A El Haj Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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N Nowotny Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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J M Conlon Departments of Obstetrics and Gynecology,
Medical Microbiology and
Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Department of Obstetrics and Gynecology, University Hospital, SE 221 85, Lund, Sweden
Zoonoses and Emerging Infections Group, Clinical Virology, University of Veterinary Medicine, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Vienna, Veterinärplatz 1, A-1210 Vienna, Austria

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). In the present article, we report on the quantitative transcription of the OT gene and the identification of OT in the uterus of pregnant rats and describe the dependence of OT gene expression on sex steroids in ovariectomized rats

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Natali Anne Henderson Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Gerard M Cooke Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Bernard Robaire Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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by complex region-specific gene expression profiles ( Jervis & Robaire 2001 , Cornwall et al. 2002 ). Theunique patternsofgene expression alongtheduct contribute to the evolving repertoire of components that make up the highly specialized luminal

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Noriko Sakai
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Hiromi Terami
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Shinobu Suzuki
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Megumi Haga
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Ken Nomoto
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Nobuko Tsuchida
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Ken-ichirou Morohashi Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Naoaki Saito Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Maki Asada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Megumi Hashimoto Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Daisuke Harada Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Hiroshi Asahara Department of Stem Cell Based Drug Discovery, Division of Sex Differentiation, Laboratory of Molecular Pharmacology, Department of Systems Biomedicine, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650-0047, Japan

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Tetsuya Ishikawa
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Fumiki Shimada
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Kazuhiro Sakurada
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of the steroidogenic cytochrome P450 genes in endocrine tissues, such as the adrenal cortex, testis, and ovary ( Morohashi et al . 1992 ). Previously, Crawford et al . (1997) using stable ectopic expression of NF5A1 in mouse embryonic stem (ES

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Akhilesh K Pandey Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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Wei Li Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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Xiangling Yin Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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Douglas M Stocco Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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Paula Grammas Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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XingJia Wang Garrison Institute on Aging, Department of Cell Biology and Biochemistry, Department of Neuropsychiatry

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using a blocker, verapamil ( Manna et al . 1999 ). However, observations on the roles of L-type Ca 2+ channels in Star gene expression and steroidogenesis were not consistent in the previous studies. While blocking Ca 2+ influx through L-type Ca 2

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Gilvanildo Roberto da Silva Department of Pathology, Federal University of Pernambuco, Recife, Brazil
Agrarian Sector, Federal University of Paraná, Veterinary Hospital, Curitiba, Brazil

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Mariane Gomes Carneiro Department of Pathology, Federal University of Pernambuco, Recife, Brazil

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Miriam Pereira Barbosa Department of Biomedicine, Federal University of Pernambuco, Recife, Brazil

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Jaciane de Almeida Costa Department of Pathology, Federal University of Pernambuco, Recife, Brazil

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Ivone Antonia de Souza Department of Pharmacology, Federal University of Pernambuco, Recife, Brazil

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Lisiane dos Santos Oliveira Academic Center of Vitória de Santo Antão, Federal University of Pernambuco, Recife, Brazil

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Diogo Antonio Alves de Vasconcelos Department of Nutrition, Federal University of Pernambuco, Recife, Brazil

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Elizabeth do Nascimento Department of Nutrition, Federal University of Pernambuco, Recife, Brazil

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Rhowena Jane Barbosa Matos Health Sciences Center, Federal University of Reconcavo da Bahia, Cruz das Almas, Brazil

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Sandra Lopes de Souza Department of Anatomy, Federal University of Pernambuco, Recife, Brazil

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Manuela Figueiroa Lyra de Freitas Department of Pathology, Federal University of Pernambuco, Recife, Brazil
Department of Anatomy, Federal University of Pernambuco, Recife, Brazil

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molecular analysis by real-time PCR. Analysis of the gene expression of tyrosine hydroxylase, Drd 1 a , and Drd 2 in the nucleus accumbens and striatum Gene expression analysis was performed in groups (TH): UC n   = 5, TC ( n   = 4), UHF ( n

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Thin Xuan Vo Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1

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Andrew Revesz Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1

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Gurjeev Sohi Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1

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Noelle Ma Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1

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Daniel B Hardy Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Departments of Physiology and Pharmacology, Obstetrics and Gynecology, The Children's Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5C1

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implicated in regulating genes involved in the metabolism and transport of cholesterol ( Lehmann et al . 1997 , Venkateswaran et al . 2000 ) and in enhancing the expression of lipogenic enzymes ( Repa et al . 2000 ). Recent studies have also demonstrated

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Emin Umit Bagriacik Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey
Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Melek Yaman Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Rauf Haznedar Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Gulsan Sucak Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Tuncay Delibasi Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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investigate the expression and biological function(s) of the TSHR in hBMSCs. TSH-induced gene expression was explored particularly. Materials and Methods Isolation and maintenance of mesenchymal stem cells hBMSCs were isolated by plastic adherence according to

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