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James S M Cuffe School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia
School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia
Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Zarqa Saif Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Anthony V Perkins School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia

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Karen M Moritz School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia

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Vicki L Clifton Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Introduction Maternal glucocorticoid exposure programs offspring disease in a sexually dimorphic manner ( O’Regan et al . 2004 , Singh et al . 2012 ). This is in part due to sexually dimorphic placental responses to glucocorticoids during

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0171
Volume/Issue:
Volume 234: Issue 2
Free access
C E Waters
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A Stevens
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A White
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D W Ray
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Introduction The ectopic adrenocorticotrophin (ACTH) syndrome is a dramatic clinical example of glucocorticoid resistance where secretion of ACTH peptides is markedly resistant to the normal negative feedback of circulating

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05804
Volume/Issue:
Volume 183: Issue 2
Free access
Hershel Raff Endocrine Research Laboratory, Aurora St Luke’s Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
Center for Neuropharmacology and Neurosciences, Albany Medical College, Albany, New York 12208, USA

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Lauren Jacobson Endocrine Research Laboratory, Aurora St Luke’s Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
Center for Neuropharmacology and Neurosciences, Albany Medical College, Albany, New York 12208, USA

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). Successful adaptation to neonatal hypoxia requires a coordinated physiological response, including an increase in the release of glucocorticoids from the adrenal cortex ( Hanukoglu et al. 1995 ). Understanding the mechanisms by which the resulting increase

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0103
Volume/Issue:
Volume 192: Issue 2
Free access
Zoi Michailidou Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Anthony P Coll Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Christopher J Kenyon Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Nicholas M Morton Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Stephen O’Rahilly Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Jonathan R Seckl Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Karen E Chapman Endocrine Unit, Queen’s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge CB2 2XY, UK

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Introduction Glucocorticoids exert pleiotrophic effects on metabolism and energy partitioning. Centrally, they increase food intake and reduce energy expenditure, whilst peripherally, they promote insulin resistance, fat accumulation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0090
Volume/Issue:
Volume 194: Issue 1
Free access
Ronald J van der Sluis Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Miranda Van Eck Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Menno Hoekstra Division of Biopharmaceutics, Cluster BioTherapeutics, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands

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Introduction Cholesterol is the sole precursor for the synthesis of steroid hormones including adrenal-derived glucocorticoids, i.e., cortisol in man and corticosterone in rodents. The cholesterol used for steroidogenesis can theoretically be

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0023
Volume/Issue:
Volume 226: Issue 3
Free access
George Schlossmacher Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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Adam Stevens Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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Anne White Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences
Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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Glucocorticoid treatment of cancer Glucocorticoids (Gcs) are widely used for the treatment of lymphoid malignancy ( Pirotte et al . 1997 , Sionov et al . 2008 ) because of their dramatic effects on cell cycle progression and apoptosis. They are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0135
Volume/Issue:
Volume 211: Issue 1
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D W Ray
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Both generalised and tissue-specific glucocorticoid resistance is increasingly being recognised. In one study, 1–2% of patients evaluated for adrenal disorders were glucocorticoid-resistant (Werner et al. 1992). At the molecular level, resistance to glucocorticoids is usually defined using specific markers. Some cells, such as lymphocytes, exhibit a very clear phenotypic change in response to glucocorticoids, enabling this to be used as a marker of glucocorticoid action (Kaspers et al. 1994). In most cells, however, changes in target gene expression are used. Either endogenous or transfected genes can be used; however, endogenous genes are often subject to tissuespecific regulation, and measurement of the steady-state mRNA level is an insensitive measure of glucocorticoid action. Transfection of short, carefully defined sequences of glucocorticoid-regulated DNA linked to a suitable reporter gene (Fig. 1) enables small differences in the EC50 and Vmax values of glucocorticoid action to be confidently measured (Ray et al. 1994b). Typically, positively

Article Type:
Letter
DOI:
https://doi.org/10.1677/joe.0.1490001
Volume/Issue:
Volume 149: Issue 1
Restricted access
Nan Yang Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Giorgio Caratti Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Louise M Ince Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Toryn M Poolman Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Peter J Trebble Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Cathy M Holt Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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David W Ray Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Laura C Matthews Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Introduction Glucocorticoids (Gc) are potent anti-inflammatory agents and are widely prescribed for the treatment of a range of inflammatory and immune diseases including rheumatoid arthritis and asthma ( McMaster & Ray 2007 , Barnes & Adcock 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0456
Volume/Issue:
Volume 223: Issue 2
Open access
Eduardo Roggero Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Ana R Pérez Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Maximiliano Tamae-Kakazu Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Isabel Piazzon Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Irene Nepomnaschy Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Hugo O Besedovsky Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Oscar A Bottasso Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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Adriana del Rey Instituto de Inmunología, Facultad de Ciencias Médicas, Santa Fé 3100, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Ilex-Conicet, Instituto de Investigaciones Hematológicas, Pacheco de Melo 308, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina
Department of Immunophysiology, Institute of Physiology, Medical Faculty, Deutschhausstrasse 2, Philipps University, 35037 Marburg, Germany

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neuroendocrine mechanisms may play in the development of the disease ( Savino et al. 1989 , Leite de Moraes et al. 1991 ). We have chosen to study, in particular, the significance of endogenous glucocorticoids levels for the course of T. cruzi infection

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06642
Volume/Issue:
Volume 190: Issue 2
Free access
Erin Faught Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Mathilakath M Vijayan Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Introduction Both intrauterine and early postnatal environments program various physiological systems in vertebrates. Major factors affecting fetal growth include maternal nutrition and fetal stress. Excess glucocorticoids (GCs) are of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0358
Volume/Issue:
Volume 244: Issue 2
Restricted access