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T Clark Brelje, Nicholas V Bhagroo, Laurence E Stout, and Robert L Sorenson

Introduction During pregnancy, there is an increased need for insulin to accommodate the developing insulin resistance and growing fetal compartment. The pancreatic islets of Langerhans meet this demand by increasing both insulin secretion and islet

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Henrik Mosén, Albert Salehi, Ragnar Henningsson, and Ingmar Lundquist

bicarbonate buffer (pH 7.4), supplemented with 10 mM HEPES, 0.1% BSA and 1 mM glucose. When only insulin secretion was studied, we used batches of ten islets in 1 ml incubation medium. When islet lysosomal enzymes were determined as well, batches of 30 islets

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Anthony J Weinhaus, Laurence E Stout, Nicholas V Bhagroo, T Clark Brelje, and Robert L Sorenson

et al. 1992 , Sorenson & Brelje 1997 ). The most important changes are lowering of the threshold for glucose-stimulated insulin secretion and expansion of islet mass ( Parsons et al. 1992 ). The primary factorsresponsible for these adaptive changes

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Jia-Jiun Yan, Yi-Chun Lee, Yi-Ling Tsou, Yung-Che Tseng, and Pung-Pung Hwang

current knowledge of organismal response to salinity challenges, certain hormones exert rapid actions to activate salt secretion through regulation of existing transporters and ionocytes in the gills during the acute phase (minutes to hours) of exposure

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J M A Hannan, L Marenah, L Ali, B Rokeya, P R Flatt, and Y H A Abdel-Wahab

were evaluated for their effects on insulin secretion using isolated perfused rat pancreas, isolated islets and clonal BRIN-BD11 cells. Materials and Methods Plant material and preparation of extracts and fractions

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Rosiane A Miranda, Rosana Torrezan, Júlio C de Oliveira, Luiz F Barella, Claudinéia C da Silva Franco, Patrícia C Lisboa, Egberto G Moura, and Paulo C F Mathias

, producing hyperinsulinemia during fasting and feeding states ( Shafrir 1996 ). Why is glucose-induced insulin secretion upregulated in obese human beings and experimental animal models? Several hypotheses have been proposed. One hypothesis is largely

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Aoife Kiely, Neville H McClenaghan, Peter R Flatt, and Philip Newsholme

Introduction Nutrient metabolism is tightly coupled to insulin secretion in the pancreatic β cell ( McClenaghan 2007 ). Mitochondrial metabolism is crucial for the coupling of glucose and amino acid recognition to exocytosis of

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K K Sidhu, R C Fowkes, R H Skelly, and J M Burrin

the synthesis and secretion of insulin in a glucose-dependent manner. Indeed, GLP-1 has turned out to be the most potent and efficacious regulatory stimulator of insulin secretion discovered so far ( Fehmann et al. 1995 ). These beneficial effects

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Ashley I Taylor, Nigel Irwin, Aine M McKillop, Steven Patterson, Peter R Flatt, and Victor A Gault

. 1992 , 2003 ). In addition, xenin is now thought to be involved in the regulation of calorie intake ( Leckstrom et al . 2009 ) and possibly insulin secretion ( Silvestre et al . 2003 ). Thus, the aim of the current study was to evaluate the effects

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Saeed Alshahrani and Mauricio Di Fulvio

Introduction Type 2 diabetes mellitus (T2DM) is a poly-endocrine and metabolic disorder characterised by chronic hyperglycaemia and relative insulin deficiency. T2DM is consequence of either prevalent impairment of insulin secretion associated with