Search Results

You are looking at 41 - 50 of 2,189 items for :

  • Refine by Access: All content x
Clear All
Free access

Chunyan Zhao and Karin Dahlman-Wright

Liver X receptor The liver X receptors (LXRs), LXRα (NR1H3) and LXRβ (NR1H2), belong to the nuclear receptor superfamily of ligand-activated transcription factors ( Janowski et al . 1996 ). LXRα was initially isolated from a rat liver cDNA library

Free access

Wing-Yee Lui, Yan Ho Cheng, Dolores D Mruk, Chin Ho Cheng, Meng Yun Mo, Will M Lee, and C Yan Cheng

the liver, and it is one of the major acute-phase serum proteins associated with inflammatory response ( Kushner 1982 ). Serum α 2 -MG is also capable of binding to a broad spectrum of cytokines, such as transforming growth factor ( Huang et al. 1988

Free access

Dieuwertje C E Spaanderman, Mark Nixon, Jacobus C Buurstede, Hetty H C M Sips, Maaike Schilperoort, Eline N Kuipers, Emma A Backer, Sander Kooijman, Patrick C N Rensen, Natalie Z M Homer, Brian R Walker, Onno C Meijer, and Jan Kroon

glucocorticoids can have sexually dimorphic actions ( Duma et al . 2010 , Quinn & Cidlowski 2016 ). For example, in the liver the synthetic glucocorticoid dexamethasone differentially affects expression of many GR target genes in male vs female rats ( Duma et

Free access

Hamzeh Karimkhanloo, Stacey N Keenan, Emily W Sun, David A Wattchow, Damien J Keating, Magdalene K Montgomery, and Matthew J Watt

Introduction Hepatokines are liver-secreted proteins that can signal to, and induce, metabolic effects in the liver and other peripheral tissues including adipose tissue, skeletal muscle and pancreas ( Meex et al. 2015 ). Altered hepatokine

Free access

Johan Svensson, Jon Kindblom, Ruijin Shao, Sofia Movérare-Skrtic, Marie K Lagerquist, Niklas Andersson, Klara Sjögren, Katrien Venken, Dirk Vanderschueren, John-Olov Jansson, Olle Isaksson, and Claes Ohlsson

IGF1 is liver derived ( Sjögren et al . 1999 , Yakar et al . 1999 ). A mouse model with liver-specific, inducible inactivation of the Igf1 gene, using the Cre-LoxP conditional knockout system, has been developed (LI-IGF1 −/− mice; Sjögren et al

Free access

Wonsuk Choi, Joon Ho Moon, and Hail Kim

transporters (VMAT), with the remaining free 5-HT in portal blood being primarily metabolized in the liver. Thus, >95% of 5-HT is stored in platelets, with free 5-HT levels being low in peripheral blood ( Holmsen 1989 , Richter et al. 1989 , El-Merahbi et

Free access

Rita E Roberts, Jacqueline Cavalcante-Silva, Rhonda D Kineman, and Timothy J Koh

wound healing, IGF-1 is present at high levels in the circulation and the liver is the major source of circulating IGF-1 in mice ( Yakar et al. 1999 ). In humans, IGF-1 levels in wounds are correlated with those in blood, suggesting that blood is the

Free access

Gabriel Forn-Cuní, Monica Varela, Conrado M Fernández-Rodríguez, Antonio Figueras, and Beatriz Novoa

diseases are part of a condition termed metabolic syndrome. The hepatic component of metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This term comprises a wide range of progressive liver injuries including bland steatosis, variable degrees

Free access

S Eleswarapu and H Jiang

Introduction Growth hormone (GH) is a pituitary polypeptide hormone that plays a central role in animal growth and metabolism ( Harvey et al. 1995 ). A major target organ of GH is the liver, where GH regulates the expression of

Free access

Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, and Liping Luo

Introduction Nonalcoholic fatty liver disease (NAFLD), characterized mainly by hepatic steatosis, is the most common liver disease worldwide ( Birkenfeld & Shulman 2014 , Meex & Watt 2017 ). It is reported that NAFLD is closely associated