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( Noubiap et al. 2022 ). Similarly, the prevalence of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is increasing ( Moore 2010 , Sahota et al. 2020 , Riazi et al. 2022 ). The metabolic syndrome, with

for generating mouse models of human diseases have greatly facilitated studies of complex inherited endocrine and metabolic syndromes that have investigated mechanisms and treatments, which would not be easily feasible in man. In addition, the

the metabolic syndrome . Cardiovascular & Hematological Agents in Medicinal Chemistry 9 137 – 146 . ( doi:10.2174/187152511797037547 ) Barrett-Connor E Khaw KT 1988 Endogenous sex hormones and cardiovascular disease in men. A prospective

, Stockholm and Center for Inherited Metabolic Diseases, Karolinska University Hospital, Solna) and C-peptide levels were evaluated using ELISA (Alpco Diagnostics, Salem, NH, USA). IPinsTT and IPGTT IPinsTT and IPGTT were performed during the fourth or fifth

method shows potential for in vivo assessment of the hepatic metabolism and for investigating metabolic complications associated with liver disease, including nonalcoholic fatty liver disease, hepatitis, cirrhosis and diabetes. With the development of

, minimizing environmental stressors to fetus/offspring. Our data suggest that such temporal and mild maternal GDM exposure increases vulnerability for metabolic disease in the offspring. Our protocol allows scalable generation of a large cohort of GDM dams and

methods to predict disease onset. In accordance with the other ‘omics’ techniques, such as genomics, transcriptomics or proteomics, the term metabonomics, which is synonymous with metabolomics or metabolic profiling, was first introduced by Nicholson et

relationship between p53, metabolism and metabolic diseases has become a new focal point for p53 researchers ( Sano et al . 2007 , Vousden & Ryan 2009 , Berkers et al . 2013 ). This review will cover the role of p53 in metabolism, with focus on its role in

Introduction Type 2 diabetes mellitus (T2DM) is a chronic metabolic isorder characterized by hyperglycemia in the context of insulin resistance (IR) and insulin secretion deficiency due to β-cell dysfunction. The global prevalence of T2DM is

Introduction The metabolic syndrome consists of a combination of risk factors that include abdominal obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. It increases the risk of cardiovascular disease and type 2 diabetes