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Chiung-Kuei Huang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Soo Ok Lee George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Eugene Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Case Cardiovascular Institute Research Institute, Case Western Reserve University, Cleveland, OH, USA

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Haiyan Pang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Chawnshang Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan

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, suggesting the androgen levels might need to be balanced. Therefore, androgen/AR signaling might not be the suitable therapeutic target in heart failure patients. AR effects on the metabolic syndrome/diabetes and their impacts on CVDs Earlier we

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Elena Maneschi
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Linda Vignozzi
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Annamaria Morelli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Tommaso Mello Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Sandra Filippi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Ilaria Cellai
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Paolo Comeglio
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Erica Sarchielli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Alessandra Calcagno Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Benedetta Mazzanti Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Roberto Vettor Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Gabriella Barbara Vannelli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Luciano Adorini Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Mario Maggi
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Introduction The metabolic syndrome (MetS) is a constellation of metabolic abnormalities centered on insulin resistance and visceral fat accumulation. In addition to insulin resistance and visceral obesity, MetS is accompanied by dyslipidemia with

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Harman S Mattu Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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Harpal S Randeva Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

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nutrition) have been shown to interact (including through metabolic syndrome, MetS) and contribute to CVD. White adipose tissue (WAT) has been identified as a metabolically active endocrine organ that affects a plethora of body functions including energy and

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Alpana Mathur Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Babu Banarasi Das University, BBD City, Lucknow, India

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Vivek Kumar Pandey Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India

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Poonam Kakkar Herbal Research Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Babu Banarasi Das University, BBD City, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-IITR, Lucknow, India

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physical exercise and its effect on the hepatic glucose production in an insulin resistance state . Diabetology and Metabolic Syndrome 7 67 . ( doi:10.1186/s13098-015-0064-x ) Mendoza MC Blenis J 2007 PHLPPing it off: phosphatases get in

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Miski Scerif Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Tamás Füzesi Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Julia D Thomas Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Blerina Kola Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Ashley B Grossman Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Csaba Fekete Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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Márta Korbonits Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

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, impaired glucose tolerance, insulin resistance, dyslipidaemia, hepatic steatosis and systemic arterial hypertension, a state similar to the metabolic syndrome ( Pivonello et al . 2005 ). Cardiac abnormalities, such as left ventricular hypertrophy

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Zhongxiuzi Gao Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Li Zhang Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Wenting Xie Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Siqi Wang Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Xiaorui Bao Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Yuli Guo Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Houjian Zhang Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Qingzhong Hu Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Yi Chen Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Zeen Wang Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Maoqiang Xue Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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Guanghui Jin Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

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et al . 2012 ). Menin, encoded by MEN1 , is a tumor suppressor, and its loss of function causes MEN1 syndrome ( Marx 2005 ). It is widely expressed in various tissues, including metabolic tissues such as the pancreas and liver ( Guru et al . 1999

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Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Introduction Metabolic health is at risk in societies with an excess supply of energy-dense palatable food and drinks and an everyday life with low physical activity. There is a global epidemic of metabolic syndrome ( Saklayen 2018 ), which

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Fiona Roberts Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Greg Markby Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Scott Dillon Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Colin Farquharson Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Vicky E MacRae Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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. 1996 , Kirsch et al. 1997 , Nielsen et al. 2001 , Yoshiko et al. 2007 , Golub 2009 , Bourgine et al. 2011 ). Metabolic syndrome Metabolic syndrome is a global epidemic, with rates increasing alarmingly across both developed and

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Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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diabetes? Diabetes, Metabolic Syndrome and Obesity 7 241 – 253 . Cruz-Jentoft AJ Baeyens JP Bauer JM Boirie Y Cederholm T Landi F Martin FC Michel JP Rolland Y Schneider SM ,. 2010 Sarcopenia: European

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Xinyu Qi Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China

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Chuyu Yun Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China

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Baoying Liao Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

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Jie Qiao Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China
National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Beijing, China

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Yanli Pang Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

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Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women of reproductive age. The prevalence of PCOS is approximately 5–10% ( Norman et al. 2007 ). It is characterized by a

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