either leptin or the LepR are characterised by severe hyperphagia and morbid obesity, as well as other hormonal abnormalities ( Robertson et al . 2008 ). Previous studies have shown that leptin promotes neutrophil and monocyte chemotaxis as well as the
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Dario A Gutierrez and Alyssa H Hasty
Rita E Roberts, Jacqueline Cavalcante-Silva, Rhonda D Kineman, and Timothy J Koh
:100; Biolegend, San Diego, California, US), macrophage accumulation by staining for F4/80 (BM8, 1:100, Thermo Fisher Scientific, Waltham, Massachusetts, US) and neutrophil accumulation by staining for Ly6G (1A8, 1:100, BD Biosciences, Franklin Lakes, New Jersey
T Yada, H Kaiya, K Mutoh, T Azuma, S Hyodo, and K Kangawa
has been detailed in fish GHS-R ( Chan et al. 2004 ). However, expression of GHS-R gene was detected in human T cells, B cells and neutrophils, suggesting the action of ghrelin on the immune system ( Hattori et al. 2001 ). Recently, Dixit
Jane A Mitchell, Mark J Paul-Clark, Graham W Clarke, Shaun K McMaster, and Neil Cartwright
) or inhaled into the lungs ( Haddad et al. 2002 ), an inflammatory response is induced which is generally typified by the activation of macrophages and early recruitment of neutrophils. As explained above, for many years, the signalling pathways
Lesley A Hill, Tamara S Bodnar, Joanne Weinberg, and Geoffrey L Hammond
centre loop (RCL) is cleaved by proteases, including neutrophil elastase ( Hammond et al. 1990 ), chymotrypsin ( Lewis & Elder 2014 ) or the bacterial proteinase, LasB ( Simard et al. 2014 ). During inflammation, CBG acts as an acute phase ‘negative
Inmaculada C Villar, Adrian J Hobbs, and Amrita Ahluwalia
(chemoattractant cytokines) that are produced by endothelial cells among other cell types. In a model of balloon-induced vascular injury in rats MCP-1 and CINC-1, chemoattractants for monocytes and neutrophils respectively ( Miller et al . 2004 ) were suppressed
Mary C Gieske, Gi Youn Na, Yongbum Koo, Misung Jo, Thomas E Curry Jr, and Chemyong Ko
produced during the complement cascade, such as the anaphylatoxins C5a and C3a, are capable of binding to receptors on mast cells, inducing them to release histamines and prostaglandins (PGs), and can serve as chemoattractants for neutrophils, eosinophils
Clare F Hodkinson, Ellen E A Simpson, John H Beattie, Jacqueline M O'Connor, David J Campbell, J J Strain, and Julie M W Wallace
Immune parameter C3 (g/l) 89 1.28±0.21 0.375 ‡ 0.329 ‡ 0.004 C4 (g/l) 90 0.26±0.06 0.297 † 0.254* 0.004 CRP (mg/dl) 90 0.20±0.36 0.173 0.208* −0.083 Neutrophils (×10 9 /l) 90 2.87±0.87 0.151 0.398 ‡ −0.249* Gated lymphocytes Annexin
Denis Stygar, Britt Masironi, Håkan Eriksson, and Lena Sahlin
hormones. Cervical ripening is characterized by inflammatory events, such as extravasation of neutrophils and macrophages ( Stygar et al. 2001 , Osman et al. 2003 ). Polymorphonuclear leukocytes and macrophages migrate from blood vessels and accumulate
Marina C Muñoz, Valeria Burghi, Johanna G Miquet, Jorge F Giani, Ricardo D Banegas, Jorge E Toblli, Yimin Fang, Feiya Wang, Andrzej Bartke, and Fernando P Dominici
the protein abundance of Mas receptor, ACE2, ACE, AGT, podocin, neutrophil gelatinase-associated lipocalin (NGAL), and Wilms' tumor 1 (WT-1), equal amounts of solubilized proteins (40 μg) were denatured by being boiled in reducing sample buffer