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Taylor Landry East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Daniel Shookster East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Alec Chaves East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Katrina Free East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Tony Nguyen East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Hu Huang East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA
Department of Physiology, East Carolina University, Greenville, North Carolina, USA

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Obesity 15 717 – 726 . (PMID: https://pubmed.ncbi.nlm.nih.gov/1838100/ ) Bobinski F Teixeira JM Sluka KA Adair Santos ARS 2018 Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain . Pain 159 437

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Chad Osterlund Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Robert L Spencer Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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negative feedback function associated with a wide range of clinical disorders (e.g. depression, post-traumatic stress disorder, type II diabetes, chronic fatigue syndrome, fibromyalgia, and chronic facial pain) and associated precursor conditions (e

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Jiean Xu State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Qiuhua Yang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Xiaoyu Zhang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zhiping Liu State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yapeng Cao State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Lina Wang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yaqi Zhou State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Xianqiu Zeng State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Qian Ma State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yiming Xu Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

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Yong Wang Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China

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Lei Huang Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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Zhen Han Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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Tao Wang Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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David Stepp Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zsolt Bagi Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA

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Mei Hong State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China

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Yuqing Huo Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Esposito E Tosh DK Cuzzocrea S Jacobson KA , et al . 2018 Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms . Pain 159 . ( https://doi.org/10.1097/j.pain.0000000000001177

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K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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afflicts much pain and disability on its sufferers. Its underpinning molecular mechanisms are, nevertheless, not fully understood; indeed it is even still a matter of debate as to which is the preceding pathology. However, there is increasing evidence

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Prasanthi P Koganti Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Vimal Selvaraj Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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. Arakane F Sugawara T Nishino H Liu Z Holt JA Pain D Stocco DM Miller WL Strauss JF 3rd 1996 Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the

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Alessandra Bitto
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Francesca Polito
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Bruce Burnett Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Robert Levy Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Vincenzo Di Stefano
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Mary Ann Armbruster Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Herbert Marini Section of Pharmacology, Primus Pharmaceuticals, Section of Physiology and Human Nutrition, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c/o AOU Policlinico G. Martino, Via C. Valeria Gazzi, 98125 Messina, Italy

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Letteria Minutoli
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Domenica Altavilla
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Francesco Squadrito
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long-term use, such as esophageal burns and bone and muscular pain ( Ettinger et al . 1998 , Wysowski & Chang 2005 ). Osteonecrosis of the jaw, although rare and found primarily in cancer patients undergoing dental surgery, is a very serious and

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Wenpeng Dong Dialysis Center, Daqing Oilfield General Hospital, Daqing, Heilongjiang, People’s Republic of China
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Xiuxia Liu Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Huan Zhang Operating theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Tie Li Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Xudong Chen Gastroenterology Department No. 1, Jilin Central General Hospital, Jilin, Jilin, People’s Republic of China

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Fuchun Wang Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Weixia Sun Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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al . 2000 ); reduced inflammation in stool of the patients with shigellosis, along with an improvement in rectal histopathology ( Raqib et al . 2012 ); reduced the frequency of abdominal pain in patients with irritable bowel syndrome ( Banasiewicz

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Jodi F Evans Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA
Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Shahidul Islam Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Yoshihiro Urade Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Naomi Eguchi Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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Louis Ragolia Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA
Biomedical Research Core, Stony Brook University School of Medicine, Health Outcomes Research, Department of Molecular Behavioral Biology, Somnoquest Company Ltd., Winthrop University Hospital, 222 Station Plaza North, Suite 505-B, Mineola, New York 11501, USA

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sensitivity to tactile pain ( Eguchi et al . 1999 ). It also plays a protective, anti-inflammatory role in some neurological disorders such as Alzheimer's disease ( Kanekiyo et al . 2007 ) and cerebral ischemia ( Saleem et al . 2009 ). In the periphery, it

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Daniela F Bertelli Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Andressa Coope Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Andrea M Caricilli Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Patricia O Prada Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Mario J Saad Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Licio A Velloso Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing
Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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Eliana P Araujo Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing
Laboratory of Cell Signaling, Department of Internal Medicine, Department of Nursing

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was calculated for AS treated rats and a similar amount of diet was offered to the control rats. All experiments were approved by the University of Campinas Ethics Committee. Anesthesia and pain relief In all invasive experiments, mice and rats were

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Michelle Keramidas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Caroline Faudot Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Agnès Cibiel Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Jean-Jacques Feige Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Michaël Thomas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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. Molecular and Cellular Endocrinology 105 155 – 163 . Negri L Lattanzi R Giannini E Colucci M Margheriti F Melchiorri P Vellani V Tian H De Felice M Porreca F 2006 Impaired nociception and inflammatory pain sensation in mice lacking the

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