Search Results
Search for other papers by D. J. HILL in
Google Scholar
PubMed
Search for other papers by M. J. O. FRANCIS in
Google Scholar
PubMed
Search for other papers by R. D. G. MILNER in
Google Scholar
PubMed
Rat prolactin at a concentration of 50 ng/ml perfusion medium stimulated the production of somatomedin-like activity (SLA) from the perfused liver of normal rats. The effect was demonstrable in perfusions performed at 11.00 h in which rat prolactin caused a mean (±s.e.m.) increase in the uptake of [35S]sulphate into rat costal cartilage in vitro of 64 ± 14% in comparison with controls, but at 15.00 h no effect was observed. No effect of rat prolactin on hypophysectomized rat liver was detectable at 11.00 h.
Hypophysectomized and sham-operated rats were given five intravenous injections of 50 μg rat prolactin or a similar volume of hormone solvent at 12 h intervals. Plasma somatomedin activity (SMA) and cartilage metabolism, measured by the uptake of radioactive sulphate and thymidine by costal cartilage in vitro, were similar in hypophysectomized animals given rat prolactin or hormone solvent. Sham-operated rats given rat prolactin showed a significant increase of plasma SMA and cartilage metabolism compared with control animals.
The production of SLA by rat liver in response to rat prolactin may be related to the density of specific hepatic lactogenic receptors, since these are absent or present only in low numbers in hypophysectomized animals.
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
Search for other papers by O Kosti in
Google Scholar
PubMed
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
Search for other papers by P W Raven in
Google Scholar
PubMed
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
Search for other papers by D Renshaw in
Google Scholar
PubMed
Metabolic and Clinical Trials Unit, Department of Mental Health Sciences, Royal Free and University College Medical School, UCL, London, UK
Search for other papers by J P Hinson in
Google Scholar
PubMed
Introduction The Maudsley reactive (MR) and nonreactive (MNR) rat strains were originally selected for differences in open-field defecation, an action reflecting ‘fearfulness’ ( Broadhurst 1957 ). Since MRs defecate the most, while
Search for other papers by Hiroki Saito in
Google Scholar
PubMed
Search for other papers by Tomoya Nakamachi in
Google Scholar
PubMed
Search for other papers by Kazuhiko Inoue in
Google Scholar
PubMed
Search for other papers by Ryuji Ikeda in
Google Scholar
PubMed
Search for other papers by Kazuo Kitamura in
Google Scholar
PubMed
Search for other papers by Naoto Minamino in
Google Scholar
PubMed
Search for other papers by Seiji Shioda in
Google Scholar
PubMed
Search for other papers by Atsuro Miyata in
Google Scholar
PubMed
been detected in rat gastrointestinal tissues, spinal cord, pancreas, pituitary gland, and several brain areas ( Ohki-Hamazaki 2000 ). NMB binds to its receptor (NMBR) – expressed in mouse brain, esophagus, intestine, testis, and uterus – to regulate
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Kouki Mori in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Katsumi Yoshida in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Ayumi Komatsu in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Jun-ichi Tani in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Yoshinori Nakagawa in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Saeko Hoshikawa in
Google Scholar
PubMed
Division of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Search for other papers by Sadayoshi Ito in
Google Scholar
PubMed
augments interferon-γ (IFNγ)-induced class II major histocompatibility complex (MHC) antigen expression ( Weetman & Rees 1988 , Zakarija et al. 1988 ). In FRTL-5 rat thyroid cells, TNFα induces interferon regulatory factor-1 ( Mori et al. 1999 ), which
Search for other papers by J Varayoud in
Google Scholar
PubMed
Search for other papers by J G Ramos in
Google Scholar
PubMed
Search for other papers by L Monje in
Google Scholar
PubMed
Search for other papers by V Bosquiazzo in
Google Scholar
PubMed
Search for other papers by M Muñoz-de-Toro in
Google Scholar
PubMed
Search for other papers by E H Luque in
Google Scholar
PubMed
activating protein-1 (AP-1) sites, depending upon the structural properties of the ligand ( Paech et al. 1997 ). The rat uterus, a major target tissue for ovarian steroids, has served as an excellent model for studying hormonal regulation of ERα
Search for other papers by T Sakurai in
Google Scholar
PubMed
Search for other papers by K Tamura in
Google Scholar
PubMed
Search for other papers by H Kogo in
Google Scholar
PubMed
. 1998 ). In addition, PGE 2 reverses the inhibition of in vitro angiogenesis of rat aortic endothelial cells that is caused by the COX-II inhibitor NS-398 ( Jones et al. 1999 ). We recently found that the activity of COX-II may be related to the
Search for other papers by Mehmet Uzumcu in
Google Scholar
PubMed
Search for other papers by Peter E Kuhn in
Google Scholar
PubMed
Search for other papers by Jason E Marano in
Google Scholar
PubMed
Search for other papers by AnnMarie E Armenti in
Google Scholar
PubMed
Search for other papers by Lisa Passantino in
Google Scholar
PubMed
10) exposure to MXC on pre-pubertal (P20) ovarian folliculogenesis and AMH production in the ovary has not been studied. The objective of this study was to examine the effect of the estrogenic endocrine disruptor MXC on the rat ovary when
Department of Endocrinology, FuJian Union hospital, Fuzhou, P R China
Search for other papers by Binbin Guan in
Google Scholar
PubMed
Search for other papers by Wenyi Li in
Google Scholar
PubMed
Search for other papers by Fengying Li in
Google Scholar
PubMed
Search for other papers by Yun Xie in
Google Scholar
PubMed
Search for other papers by Qicheng Ni in
Google Scholar
PubMed
Search for other papers by Yanyun Gu in
Google Scholar
PubMed
Search for other papers by Xiaoying Li in
Google Scholar
PubMed
Search for other papers by Qidi Wang in
Google Scholar
PubMed
Search for other papers by Hongli Zhang in
Google Scholar
PubMed
Search for other papers by Guang Ning in
Google Scholar
PubMed
, Metukuri et al . 2012 , Zhang et al . 2012 ). In rat and mouse models, glucose infusion in vivo also results in an approximately 50% increase in β-cell proliferation ( Bonner-Weir et al . 1989 , Alonso et al . 2007 , Zhang et al . 2012 ). Glucose
Search for other papers by Jia Fang Wang in
Google Scholar
PubMed
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Lawson Health Research Institute, Medicine, Paediatrics, St Joseph's Health Care, 268 Grosvenor Street, Room H404, London, Ontario, Canada N6A 4V2 Departments of
Search for other papers by David J Hill in
Google Scholar
PubMed
Introduction Both islet endocrine cells and acinar tissue develop from pancreatic epithelium cells during the fetal and neonatal development of the rat, and in the human fetus ( Cerf 2006 , Murtaugh 2007 ). The initial development of both lineages
Search for other papers by S Peña in
Google Scholar
PubMed
Search for other papers by M Rubio in
Google Scholar
PubMed
Search for other papers by C Vargas in
Google Scholar
PubMed
Search for other papers by C Alanis in
Google Scholar
PubMed
Search for other papers by AH Paredes in
Google Scholar
PubMed
cumulus–oocyte complexes, indicating that it directly influences oocyte development ( Mo et al. 2014 ). Moreover, LIF stimulates the transition from primordial to primary follicle and supports primordial follicle viability in rat, murine and goat ovary