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Caiyun Sun State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Da Duan State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Bo Li State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Chaobin Qin State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Jirong Jia State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Bin Wang State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Haiyan Dong State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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Wensheng Li State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, No. 135, XinGang West Road, Guangzhou 510275, People's Republic of China

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demonstrated that the UII/UT system is involved in the control of cardiovascular activity ( Watson & May 2004 , Vaudry et al . 2010 ), locomotor activity, orexigenic and dipsogenic response ( Do-Rego et al . 2005 ), sleep ( de Lecea & Bourgin 2008 ), and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0282
Volume/Issue:
Volume 220: Issue 1
Free access
Francesca Spiga Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Jamie J Walker Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Rita Gupta Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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John R Terry Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stafford L Lightman Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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stress. In addition to this, our model points to the existence of a short time delay in this intra-adrenal inhibition, and that upon ACTH stimulation, this local negative feedback mechanism is rapidly antagonized, presumably via ACTH activation of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0132
Volume/Issue:
Volume 226: Issue 2
Free access
Ting Chen State Key Laboratory of Biocontrol, School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Zhiguo Tang State Key Laboratory of Biocontrol, School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Aifen Yan State Key Laboratory of Biocontrol, School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Wensheng Li State Key Laboratory of Biocontrol, School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Haoran Lin State Key Laboratory of Biocontrol, School of Life Sciences, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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gpGhsr1b has a larger transcript size than gpGhsr1a , it actually encodes for a shorter truncated form of gpGhsr1a . Figure 2 Comparisons of nucleotide and amino acid sequences between gpGHSR1a and gpGHSR1b. TM domains are boxed. The aa sequence

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0325
Volume/Issue:
Volume 199: Issue 2
Free access
J Bancroft The Kinsey Institute, Indiana University, Morrison Hall third floor, Bloomington, Indiana 47405, USA

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stimulus ( Carani et al. 1995 ). Nocturnal penile tumescence (NPT), the occurrence of spontaneous erections during rapid eye movement (REM) sleep, is relevant. The neurophysiological basis of NPT is still disputed, but one plausible

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06233
Volume/Issue:
Volume 186: Issue 3
Free access
Silvia Begliuomini
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Elena Lenzi
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Filippo Ninni
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Elena Casarosa
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Sara Merlini
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Nicola Pluchino
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Valeria Valentino
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Stefano Luisi Division of Gynecology and Obstetrics, Division of Obstetrics and Gynecology, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy

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Michele Luisi
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Andrea R Genazzani
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. In fact, it has been shown that BDNF presents a very short half-life in plasma ( t 1/2 =0.92 min; Poduslo & Curran 1996 ), and then it is conceivable that BDNF is secreted with a pulsatory circadian rhythm, featured by a progressive reduction in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0376
Volume/Issue:
Volume 197: Issue 2
Free access
Alison Mostyn Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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Sylvain Sebert Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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Jennie C Litten Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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Katharine S Perkins Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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John Laws Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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Michael E Symonds Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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Lynne Clarke Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK

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lack of leptin-binding protein. A portion of leptin found in the circulation exists bound to a short form of the leptin receptor thought to be a binding protein ( Huang et al. 2001 ). Although the long- and short-form of the leptin receptor are

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06731
Volume/Issue:
Volume 190: Issue 3
Free access
Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Peter Aldiss Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Neele Dellschaft Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Hernan P Fainberg Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Harold Sacks VA Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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the thermal environment The development and maturation of adipose tissue varies substantially between large and small mammals. The latter are born with an immature hypothalamic–pituitary axis after a short gestation with very little capacity for

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0084
Volume/Issue:
Volume 238: Issue 1
Free access
Eva M G Viho Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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Richard A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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René Houtman Precision Medicine Lab, Oss, the Netherlands

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Elisabeth S R van den Dungen Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands

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Hazel J Hunt Corcept Therapeutics, Menlo Park, CA, USA

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Leo J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Onno C Meijer Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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metabolic syndrome, i.e. visceral fat accumulation, insulin resistance, hypertension and dyslipidemia ( Kalsbeek et al. 2015 ), and with a range of neuropsychiatric symptoms such as depression, impaired memory and sleep disturbances ( Pivonello et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0263
Volume/Issue:
Volume 256: Issue 2
Open access
Shelley Gorman Telethon Kids Institute, University of Western Australia, Perth, Australia

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Alexander N Larcombe Telethon Kids Institute, Perth, Australia
School of Population Health, Curtin University, Perth, Australia

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Hayley E Christian Telethon Kids Institute, University of Western Australia, Perth, Australia

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outdoor physical activity, with other proposed benefits for mental health, sleep, social contact, and reduced exposure to urban pollutants such as carbon dioxide (CO 2 ), particulate matter, noise and heat ( Kumar et al. 2019 ). Potential risks from

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0487
Volume/Issue:
Volume 249: Issue 1
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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pathways ( Joels & Baram 2009 ). Almost without exception, this involves G-protein-coupled receptors, which upon binding of the ligand mediate actions that develop within minutes and generally are short lasting, due to dissociation of the ligand from the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0226
Volume/Issue:
Volume 238: Issue 3
Free access