and −293 Luc backgrounds than in −251 Luc in β cells (Fig. 4C ), implying that interactions between PDX-1 and factors binding within the distinctive Z region are fundamental to human insulin transcription. The activity of the Z region appears to be
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Melyssa R Bratton, James W Antoon, Bich N Duong, Daniel E Frigo, Syreeta Tilghman, Bridgette M Collins-Burow, Steven Elliott, Yan Tang, Lilia I Melnik, Ling Lai, Jawed Alam, Barbara S Beckman, Steven M Hill, Brian G Rowan, John A McLachlan, and Matthew E Burow
estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I . Molecular Endocrinology 7 743 – 752 . doi:10
Aarti D Rohira, David M Lonard, and Bert W O’Malley
production which acts by regulating stromal COUP-TFII signaling to promote decidualization. In another example, conditional deletion of the ER gene in the uterine epithelial compartment leads to loss of LIF production. Furthermore, the transcription factor
Alena Nareika, Yeong-Bin Im, Bryan A Game, Elizabeth H Slate, John J Sanders, Steven D London, Maria F Lopes-Virella, and Yan Huang
activities of AP-1, nuclear factor κB (NFκB), and early growth response 1, which play an important role in the transcriptional activation of genes involved in inflammation. In addition to the effect of high glucose on gene expression as described above, our
Hong-Wei Wang, Michelle Muguira, Wei-Dong Liu, Tao Zhang, Chiachen Chen, Rebecca Aucoin, Mary B Breslin, and Michael S Lan
Introduction Insulin gene transcription is regulated by both the ubiquitous and the β-cell-specific transcription factors ( Melloul et al . 2002 , Brink 2003 ). In β-cells, multiple regulatory elements in the basal insulin promoter control insulin
Ichiro Kaneko, Rimpi K Saini, Kristin P Griffin, G Kerr Whitfield, Mark R Haussler, and Peter W Jurutka
sensitive to inhibition by cycloheximide ( Kolek et al . 2005 , Haussler et al . 2010 ), suggesting that the transcriptional effect may be secondary and dependent on the induction of an intermediary transcription factor. However, the time course of FGF23
Joyce Emons, Bas E Dutilh, Eva Decker, Heide Pirzer, Carsten Sticht, Norbert Gretz, Gudrun Rappold, Ewan R Cameron, James C Neil, Gary S Stein, Andre J van Wijnen, Jan Maarten Wit, Janine N Post, and Marcel Karperien
. 1993 ), indicating that both hormones can have direct effects on the growth plate. Stimulation of the GH receptor activates an intracellular signal transduction cascade eventually converging to the transcription factor STAT5B ( Rosenfeld & Hwa 2009
Itsuo Murakami, Sakae Takeuchi, Toshiyuki Kudo, Shizuyo Sutou, and Sumio Takahashi
. 1989 b ). Cell-type specific expression of the POMC gene in corticotropes and melanotropes is maintained by the expression of Tpit (also called Tbx19), a Tbox family transcription factor, and pituitary homeobox 1 (Pitx1), a homeoprotein transcription
Bo Chen, Yanrong Lu, Younan Chen, and Jingqiu Cheng
activity is disrupted, it is no longer possible to maintain appropriate redox balance. Nuclear factor-E2-related factor 2 (Nrf2), a transcription factor with a high sensitivity to oxidative stress, binds to antioxidant response elements (AREs) in the
Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei, and Huijun Duan
wide range of transcription factors involved in cellular energy metabolism. By regulating the activities of these transcription factors, PGC-1α acts as a molecular switch for multiple cellular processes, including mitochondrial biogenesis and
