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Marcelo A Christoffolete
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Márton Doleschall Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Péter Egri Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Zsolt Liposits Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Ann Marie Zavacki Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Antonio C Bianco Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Balázs Gereben Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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and Development 9 1033 – 1045 . Wu Y Koenig RJ 2000 Gene regulation by thyroid hormone . Trends in Endocrinology and Metabolism 11 207 – 211 . Zavacki AM Lehmann JM Seol W Willson TM Kliewer SA Moore DD 1997 Activation

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K Alexander H Iwen Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Oezge Senyaman Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Arne Schwartz Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Maren Drenckhan Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Britta Meier Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Dirk Hadaschik Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Johannes Klein Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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five independent experiments and a representative immunoblot is shown. Actin served as loading control. * P <0.05, ** P <0.01. p38 MAPK mediates UCP-1 induction by ACTH p38 MAPK pathways have been reported to mediate UCP-1 gene regulation. Using a

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Seiji Tsutsumi
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Xi Zhang
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Keiko Takata
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Kazuhiro Takahashi
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Richard H Karas Department of Obstetrics and Gynecology, Molecular Cardiology Research Institute, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

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Hirohisa Kurachi
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Michael E Mendelsohn Department of Obstetrics and Gynecology, Molecular Cardiology Research Institute, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

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between SRC-1 and CREB binding protein . Molecular and Cellular Biology 20 8720 – 8730 . Sanches R Nguyen D Rocha W White JH Mader S 2002 Diversity in the mechanisms of gene regulation by estrogen receptors . BioEssays 24 244 – 254

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C E Waters
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A Stevens
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A White
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D W Ray
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peptide gene regulation (as in the ectopic ACTH syndrome) but also have relevance as a mechanism which could contribute to the malignant cell phenotype. Figure 1 Glucocorticoid regulation of the TAT3-luc reporter gene in COR L103 cells. (A) COR L

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Matthias Haase Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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Matthias Schott Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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Stefan R Bornstein Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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Ludwik K Malendowicz Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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Werner A Scherbaum Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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Holger S Willenberg Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, D-40225 Duesseldorf, Germany
University of Technology Dresden, University Clinic III, Dresden, Germany
School of Medicine, Department of Histology and Embryology, Poznan, Poland

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of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation. Molecular Endocrinology 15 57 –68. Ho MM & Vinson GP 1995 Endocrine control of the distribution of basic

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Christoph Melcher Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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Ruediger Bader Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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Michael J Pankratz Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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-like phenotype. The gene encodes a zinc finger transcription factor and is expressed throughout the nervous system. Microarray analysis focusing on neuropeptide gene regulation indicated that hugin was upregulated in klu mutants; hugin is expressed

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Trinna L Cuellar UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122-0534, USA

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Michael T McManus UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122-0534, USA

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Dicer is required for morphogenesis but not patterning of the vertebrate limb. PNAS 102 10898 –10903. He L & Hannon GJ 2004 MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics 5 522

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Takaharu Maruyama Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Kenichi Tanaka Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Jun Suzuki Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Hiroyuki Miyoshi Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Naomoto Harada Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Takao Nakamura Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Yasuhisa Miyamoto Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Akio Kanatani Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Yoshitaka Tamai Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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expression. Physiological Reviews 81 1269 –1304. Beato M 1989 Gene regulation by steroid hormones. Cell 56 335 –344. Bjorkhem I & Eggertsen G 2001 Genes involved in initial steps of bile

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José E Sánchez-Criado Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Carmina Bellido Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Rafaela Aguilar Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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José C Garrido-Gracia Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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1998 Cellular distribution and gene regulation of estrogen receptors α and β in the rat pituitary gland. Endocrinology 139 3976 –3983. Mobbs CV , Fink G & Pfaff DW 1990 HIP-70: a protein induced by estrogen in the

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Jennifer H Steel Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Roger White Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Malcolm G Parker Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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. Subramaniam N , Treuter E & Okret S 1999 Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. Journal of Biological Chemistry 274 18121 –18127. Torchia J , Rose DW

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