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Qiaoyuan Zheng, Hesheng Xiao, Hongjuan Shi, Tingru Wang, Lina Sun, Wenjing Tao, Thomas D Kocher, Minghui Li, and Deshou Wang

MR Sun YL Zhang XB Jiang DN Zhou LY , 2014 Efficient and heritable gene targeting in tilapia by CRISPR/Cas9 . Genetics 591 – 599 . ( ) Liu S Govoroun M D’Cotta H Ricordel MJ Lareyre

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Shu-Fang Xia, Xiao-Mei Duan, Xiang-Rong Cheng, Li-Mei Chen, Yan-Jun Kang, Peng Wang, Xue Tang, Yong-Hui Shi, and Guo-Wei Le

mice vs OP mice and putative gene targets To investigate the potential role of miRs in different propensities to HFD-induced obesity, next-generation sequencing was used in livers of OP and OR mice in the 7th week, respectively. As displayed in Table

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Esther Paulo, Dongmei Wu, Peter Hecker, Yun Zhang, and Biao Wang

conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . ( ) 10.2337/db12-1089 23321074 Lee P Werner CD Kebebew E Celi FS 2014 Functional thermogenic beige adipogenesis is inducible in human neck

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A Feraco, A Armani, R Urbanet, A Nguyen Dinh Cat, V Marzolla, F Jaisser, and M Caprio

-1541 ) 20068130 10.2337/db09-1541 Lee KY Russell SJ Ussar S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED , 2013 Lessons on conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . (

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Marian Joëls

the way from the gene target to the functional consequences. The most extensively studied pathway (calcium signaling) suggests that the gene encoding for beta4 auxiliary subunits may form a preferential genetic target for GR homodimers ( Chameau et al

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Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real, and Miguel López

M 2015 Surgery-induced weight loss is associated with the down­regulation of genes targeted by microRNAs in adipose tissue . Journal of Clinical Endocrinology and Metabolism 100 E1467 – E1476 . ( doi:10.1210/jc.2015-2357 ) Pearce EN

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Ulla Simanainen, Yan Ru (Ellen) Gao, Reena Desai, Mark Jimenez, Jennifer Spaliviero, Janet R Keast, and David J Handelsman

Acta 409 78 – 84 . ( doi:10.1016/j.cca.2009.09.003 ) Heuckeroth RO Enomoto H Grider JR Golden JP Hanke JA Jackman A Molliver DC Bardgett ME Snider WD Johnson EM Jr 1999 Gene targeting reveals a critical role for

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Gordon Moody, Pedro J Beltran, Petia Mitchell, Elaina Cajulis, Young-Ah Chung, David Hwang, Richard Kendall, Robert Radinsky, Pinchas Cohen, and Frank J Calzone

.2337/diabetes.50.5.1110 ) Yakar S Pennisi P Kim CH Zhao H Toyoshima Y Gavrilova O LeRoith D 2005 Studies involving the GH–IGF axis: lessons from IGF-I and IGF-I receptor gene targeting mouse models . Journal of Endocrinological Investigation

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J Svensson, M Diez, J Engel, C Wass, Å Tivesten, J-O Jansson, O Isaksson, T Archer, T Hökfelt, and C Ohlsson

Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation. PNAS 94 14054 –14059. Kuhn R , Schwenk F, Aguet M & Rajewsky K 1995 Inducible gene

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F E Utama, M J LeBaron, L M Neilson, A S Sultan, A F Parlow, K-U Wagner, and H Rui

achieved by genetic engineering such as transgenic overexpression or gene targeting. Three transgenic mouse strains have been reported to express rat prolactin under the metallothionine promoter ( Wennbo et al. 1997 a ), or the prostate-specific probasin